Crude drug adulteration: a concise review

The adulteration and substitution of crude drugs is a burning problem. No doubt, substitution is helpful in places where the unavailability of particular oil drugs and or unwanted adverse effects of the desired crude drugs are there and have a choice of another drug with similar pharmacological effects and less unwanted aftereffects. However, in most cases, it is unacceptable because the conversion of authentic drugs into substandard medications may cause a variety of adverse effects, from mild and moderate to severe life-threatening reactions. So, understanding all the ways of adulteration and substitution is necessary to rectify this illegal act and maximize consumers' safety. At the end of this review, the Botanical Adulterant Program of the American Botanical Council is also highlighted.

Dr. Salman Ahmed Dr. salman ahmed

Evaluation of chickpea (cicer arietinum l.) genotypes for yield and their susceptibility reaction against helicoverpa armigera (hub.)

Eighteen chickpea (Cicer arietinum L.) genotypes were evaluated for yield and their susceptibility reaction against gram pod borer, Helicoverpa armigera Hub. for three consecutive years under natural field conditions during rabi 2010-11, 2011-12 and 2012-13 at Hisar. Among these, maximum grain yield was realized from the genotype H 04-28 (13.00 q/ha) during the season rabi 2010-11 and it was statistically at par with RSG 931 (12.45 q/ha), H 03-56 (11.73 q/ha) and RSG 963 (10.82 q/ha) during rabi 2011-12 and it was statistically at par with GNG 1488 (10.01 q/ha), CSJ 140 (9.07 q/ha) and H 03-56 (8.95 q/ha) during Rabi 2012-13 and it was statistically at par with RSG 888 (8.80 q/ha) and GNG 1591 (7.79 q/ha). However, on the basis of average of three years (2010-11 to 2012-13), the maximum yield was exhibited by the genotype GNG 1488 (9.36 q/ha) followed by RSG 931 (8.95 q/ha), H 04-28 (8.32 q/ha) and H 03-56 (8.20 q/ha). The genotype H 03-56 flowered earliest in 68-71 days and proved the best donor against gram pod borer with PSR 4.7. Minimum larval population was recorded in BG 256 (15.8 l/mrl) and it was followed by GL 25016 (17.5 l/mrl) and H 04-28 (18.5 l/mrl). Minimum per cent pod infestation by H. armigera was recorded in genotype H 01-27 (27.8%) and it was superior over all other genotypes. It was followed by H 03-56 (29.5%), CSJ 140 (30.9%) and GNG 1488 (31.3%). H 01-27 proved least susceptible genotype under natural field condition. The genotype H 03-56 flowered earliest and seemed to be the best as potential donor for pod borer’s tolerance under late sown condition. GNG 1488, RSG 931, H 04-28, H 03-56 and RSG 963 proved promising genotypes for yield and against H. armigera. These genotypes may further be utilized in breeding programmes to develop the high yielding and tolerant cultivars against gram pod borer.

DR. BABU LAL JAT Dr. babu lal jat

Live bird markets in nigeria: a potential reservoir for h9n2 avian influenza viruses

Since 2006, multiple outbreaks of avian influenza (AI) have been reported in Nigeria involving different subtypes. Surveillance and molecular epidemiology have revealed the vital role of live bird markets (LBMs) in the dissemination of AI virus to commercial poultry farms. To better understand the ecology and epidemiology of AI in Nigeria, we performed whole-genome sequencing of nineteen H9N2 viruses recovered, from apparently healthy poultry species, during active surveillance conducted in nine LBMs across Nigeria in 2019. Analyses of the HA gene segment of these viruses showed that the H9N2 strains belong to the G1 lineage, which has zoonotic potential, and are clustered with contemporary H9N2 identified in Africa between 2016 and 2020. We observed two distinct clusters of H9N2 viruses in Nigeria, suggesting different introductions into the country. In view of the zoonotic potential of H9N2 and the co-circulation of multiple subtypes of AI virus in Nigeria, continuous monitoring of the LBMs across the country and molecular characterization of AIVs identified is advocated to mitigate economic losses and public health threats.

Bitrus Inuwa Bitrus inuwa

Dietary replacement of fish meal with soybean meal for the optimal growth of juvenile milkfish, chanos chanos (forsskal, 1775) in seawater tanks

The core of the current study is to find out a different source of diet that stimulates better growth rate and low-cost feed for commercial fish milkfish Chanos chanos. This study was to assess the impact of partial replacement of fish meal by soybean meal in the diet of juvenile milkfish, Chanos chanos (initial weight 25 ± 0.6 g). The juveniles were fed with two types of isonitrogenous diets (40% crude protein). Plant protein source diet (D1) comprised of soybean meal 45% and 10% fish meal, while animal protein source diet (D2) contained fish meal 25% and soybean meal 30%. The trial was conducted with two replications for 60 days. Fish juveniles (10 each) were stocked in outdoor fiberglass seawater tanks (5000 Liters). Results revealed that final weight gain (WG), and specific growth rate (SGR) were significantly lower in fish fed D2 diet. Fish fed D1 had better feed efficiency, weight gain (21.88 ± 1.9 g), and SGR (1.05 ± 0.3), while D2 had a lower growth rate, WG (18.71 ± 2.3 g) and SGR (0.93 ± 0.2). The maximum growth rate found on plant diet which is significantly higher weight gain than D2. In D2 feed conversion ratio (0.54 ± 0.21) was significantly higher (P≤0.05). Condition factor among both treatments did not differ significantly (P≥0.05). The survival rate remained constant (100%) in both treatments. Based on the obtained results, it is recommended that 45% soybean meal with addition of 10% fishmeal (40% protein) is more effective than 30% soybean meal with addition of 25% fish meal to the omnivorous milkfish for aquaculture.

Imtiaz kashani

Symmetric key cryptosystem based on randomized block cipher

Multimedia data encryption attempts to prevent unauthorized disclosure of confidential multimedia information in transit or storage. Security of multimedia files attracts more and more attention and many encryption methods have been proposed in literature. If we call a multimedia data stream (message) plaintext , the process of transforming the plaintext into unintelligible data stream is referred to as multimedia encryption (MME) where the encrypted message (data stream) is often named ciphertext. The process of transforming the ciphertext back into plaintext is termed decryption. We propose a new block cipher based on randomized key of size n × n where n is the block size and the block undergoes n 2 iterations with the plaintext. Every iteration generates the pseudo cipher text. The encryption process generate the ciphertext C with the help of the randomized key. The decryption apply the key in reverse order on the cipher text, to get back the plain text. This work deals with the problem of efficient multimedia data encryption.

S arul jothi

N-gram and k-nearest neighbour based igbo text classification model

The evolution in Information Technology has gone a long way of bringing Igbo, one of the major Nigerian languages evolved. Some online service providers report news, publish articles and search with this language. The advancement will likely result to generation of huge textual data in the language, that needs to be organized, managed and classified efficiently for easy information access, extraction and retrieval by the end users. This work presents an enhanced model for Igbo text classification. The classification was based on N-gram and K-Nearest Neighbour techniques. Considering the peculiarities in Igbo language, N-gram model was adopted for the text representation. The text was represented with Unigram, Bigram and Trigram techniques. The classification of the represented text was done using the K-Nearest Neighbour technique. The model is implemented with the Python programming language together with the tools from Natural Language Toolkit (NLTK). The evaluation of the Igbo text classification system performance was done by calculating the recall, precision and F1-measure on N-gram represented text. The result shows text classification on bigram represented Igbo text has highest degree of exactness (precision); trigram has the lowest level of precision and result obtained with the three N-gram techniques has the same level of completeness (recall). Bigram text representation technique is extremely recommended for any text-based system in Igbo. This model can be adopted in text analysis, text mining, information retrieval, natural language processing and any intelligent text-based system in the language.

Dr. Nkechi Ifeanyi-Reuben Dr. nkechi ifeanyi-reuben

Assessment of knowledge and awareness of community pharmacist toward epilepsy

Community pharmacist plays an essential role in educating the epileptic patients about their disease and medications. Improving the patient’s awareness may lead to improve their compliance and decrease drug-drug interaction and ultimately improve their quality of life. Pharmacist can detect the emergence of health problems and can help prevent progression of comorbidities. Considering the complexity of treating epilepsy and the lack of information about pharmacists’ contributions to epilepsy management, pharmacist performed pharmaceutical counselling, pharmaco-therapeutic follow-up and systematic measurement and evaluation of findings and increase medication adherence of patient with epilepsy. This study was aimed to assess the community pharmacist's knowledge about epilepsy and their treatment by antiepileptic drugs in Libya. The design of the study is a cross sectional study. The knowledge was collected through a questionnaire which included 35 questions divided into three sections: demographic data, general information about epilepsy and information about epilepsy and antiepileptic drugs. The questionnaire was prepared and validated by consultant training in Ali Omer Asker Hospital in Tripoli for two months. The findings indicate that over 200 patients are altered viewed, of whom, only epileptic patients were observed. The majority of the participants were female, qualification degree BSc and years of experience from one to five years. Unfortunately, some of the participants (40.0%) had poor knowledge and about 60.0% of them had good knowledge. This study indicates that the importance of community pharmacist in Libya requires more improvement to achieve the existing function and that the impact of continuous study of everything related to diseases and medicines is important to obtain a qualified pharmacist who can become an effective agent for a change.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Using microsoft excel in formulating poultry rations by linear programming

Formulation of the least cost rations that provides the nutrient requirements of birds is an important goal in poultry production . The aim of the present study was to create an application in the Excel program for formulation of low-cost poultry diets that provide adequate nutritional requirements using linear programming based on the Solver function of the Excel program and composition of common feed ingredients used in poultry diets (yellow corn, wheat, soybean meal , barley, wheat bran, protein concentrate, limestone, table salt, di-calcium phosphate, vitamins and minerals premix ,and vegetable oil), if their default prices are 500, 450, 750, 350, 250,1750, 250, 100, 500, 4500,and 1500) Iraqi Dinar / kg, respectively. The results showed that the Solver function in - Excel can be used to solve linear programming models such as those used for formulation of least cost poultry rations. This Microsoft Excel application is ready to use and can be used to assist researchers and students in formulating poultry rations that provide the desired nutritional requirements of poultry at the lowest cost. Key words : Application

RAFEA MOHAMMEDTAHER KHULEL Rafea mohammedtaher khulel

Evaluation of knowledge, attitude and practice of pharmacovigilance among libyan healthcare professionals

The aim of this study was to evaluate the knowledge, attitude, and practice of pharmacovigilance by healthcare professionals in Benghazi. A structured questionnaire adapted from a previous validated study. One hundred questionnaires were distributed in August 2019 and filled by healthcare providers working at different hospitals in Benghazi, Libya. Participants were 57% physicians and 43% pharmacists (age average 31-40 years). 47% had correctly defined Pharmacovigilance while 19% know what is meant by adverse drug reactions. Moreover, 61% of the participants did not share information about raising adverse drug reactions in some patients with other healthcare professionals. 35% of them did not know about the adverse drug reactions reporting system in Libya. Whereas, 42% have strongly agreed that reporting adverse drug reactions is essential. 41% and 45% of participants believed that reporting adverse drug reactions is not time-consuming and increases patient safety, respectively. In conclusion, educational programs and training courses about the importance of Pharmacovigilance for physicians and pharmacists in Benghazi are needed.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Early diagnosis of tuberculosis using deep learning approach for iot based healthcare applications

In the modern world, Tuberculosis (TB) is regarded as a serious health issue with a high rate of mortality. TB can be cured completely by early diagnosis. For achieving this, one tool utilized is CXR (Chest X-rays) which is used to screen active TB. An enhanced deep learning (DL) model is implemented for automatic Tuberculosis detection. This work undergoes the phases like preprocessing, segmentation, feature extraction, and optimized classification. Initially, the CXR image is preprocessed and segmented using AFCM (Adaptive Fuzzy C means) clustering. Then, feature extraction and several features are extracted. Finally, these features are given to the DL classifier Deep Belief Network (DBN). To improve the classification accuracy and to optimize the DBN, a metaheuristic optimization Adaptive Monarch butterfly optimization (AMBO) algorithm is used. Here, the Deep Belief Network with Adaptive Monarch butterfly optimization (DBN-AMBO) is used for enhancing the accuracy, reducing the error function, and optimizing weighting parameters. The overall implementation is carried out on the Python platform. The overall performance evaluations of the DBN-AMBO were carried out on MC and SC datasets and compared over the other approaches on the basis of certain metrics.

Dr H Shaheen Dr h shaheen

Pembelajaran edutainment dalam penanaman karakter cinta tanah air pada anak usia dini di sekolah dasar

Konsep edutainment mencoba memadukan antara pendidikan dan hiburan, yang didalam konsep edutainment tersebut terdapat beberapa pendekatan yang lebih kita kenal sebagai SAVI (Somatik, Auditori, Visual dan Intelektual). Metode penelitian ini menggunakan jenis penelitian Library research, yaitu jenis penelitian yang dilakukan dan difokuskan pada penelaahan, pengkajian dan pembahasan literature-literatur, baik klasik maupun modern. Literature berbahsa arab, inggris, Indonesia dan sebagainya yang ada kaitannya dengan persoalan ini. Penelitian ini bersifat analisis deskriptif. Sumber data penelitian ini yaitu: Sumber primer dari pemikiran Beby De Poter. Sumber skunder meliputi: buku, artikel atau esai yang membahas konsep edutainment, dan buku yang berkenaan dengan konsep psikologi belajar anak, serta buku pendidikan karakter, terutama karakter cinta tanah air. Hasil penelitian ini menunjukkan: (1) Pembelajaran Edutainment Dalam Penanaman Karakter Cinta Tanah Air Bagi Anak Usia Dini Di Sekolah Dasar, yaitu: menumbuhkan karakter cinta tanah air, memunculkan emosi minat anak seperti rasa senang dan gembira dalam pembelajaran, guru dalam menyampaikan pembelajaran di kelas harus menunjukkan sikap kepedulian terhadap peserta didik. (2) Proses Penanaman Karakter Cinta Tanah Air Bagi Anak Usia Dini Di Sekolah Dasar, yaitu: proses pembelajaran interaksi antara siswa dan guru terbangun suasana menyenangkan, fleksibiltas guru dalam menyampaikan materi menyesuaikan dengan emosi peserta didik, hubungan keakraban dan persahabatan sebagaimana teman sendiri, dan guru memberikan kebabasan berexspresi kepada perserta didik pada saat proses pembelajaran.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Preferred learning techniques among bachelor’s level students

Learning styles describe how individuals acquire, interpret, and assimilate knowledge differently. The effective use of learning styles is essential for effective classroom education. The three most popular learning styles are kinaesthetic, auditory, and visual. This study pursued to learn more about the preferred learning modes of college students. There were 152 respondents from Baneshwor Multiple Campus, Kathmandu Nepal. The data were collected from first year students of BBS, B.Ed. and BA. The researchers used a scale of learning styles (VAK) with 28 items to accomplish the study's goal, and after confirming its validity and reliability, it was applied to the sample. The results show that there are no statistically significant differences in the types of learning patterns preferred by students. Based on these findings, the study recommends that teachers are encouraged to diversify college teaching strategies and methods to suit the preferred learning styles of their students, particularly new students, in order to motivate them to learn in the college environment and to provide the training needs and requirements necessary to enable them to take individual differences among their students into account when identifying educational goals.

Dr Dasarath Neupane Dr dasarath neupane

Strain improvement studies for the production of l-asparaginase by beauveria bassiana ss18/41

Strain improvement studies were conducted for the production of L-asparaginase from a marine fungus Beauveriabassiana SS18/14 by employing physical and chemical mutagens, in a systemic manner to obtain mutants that have higher L-asparaginase production. The wild strain produced 6.32 IU/mL of L-asparaginase activity while the UV mutant UVF-4 yielded 8.34 IU/mL and nitrous acid mutant UVF4-N-2 exhibited 10.44 IU/mL enzyme activity. The overall strain improvement programme increased L-asparaginase activity 1.65 times with respect to the parent wild strain

Dr.P.V.Kamala Kumari Dr.p.v.kamala kumari

Strategic international business management - change management of sarhs

This paper aims to study the restructuring and change management of SARHS, which in turn will be accompanied by some complex, difficulties and discussions that may include personnel emotion, which must be taken into account. We will guide SARHS managers by conducting a comprehensive study of majority factors that will affect the success of the process, considering and covering all views. Which will result in the dismissal of some employees and the closure of their jobs permanently in the new job structure. The study will include many theories, models and justified recommendations to be followed to ensure a successful and safe restructuring and management change free from unresolved impediments and difficulties that could lead to a setback. Finally, restructuring is not a result but the beginning of a new process

Mohamed Sorogy Mohamed sorogy

Surface modification of anhydrous borax with stearic acid by wet coating method

The wet coating of anhydrous borax powders with stearic acid (SA) to reverse their inherent hydrophilic surface properties was investigated. The coating procedure was based on the results from a previous study that revealed that the stearic acid solution (2 wt. % SA) mixed for 60 minute at 750 rpm on the magnetic stirrer was sufficient for the surface modification of anhydrous borax. For the experiments, stearic acid powders were first dissolved in water at 80 °C. The mixture obtained by adding anhydrous borax powders to this solution was vigorously mixed on a magnetic stirrer to initiation and completion the surface modification. Each of these solutions was then filtered using a filter paper to separate the undissolved particles, and the residue on paper was dried at 50 °C for 48 h until constant weighing was obtained. Wettability has been accepted as a key parameter for success in wet coating treatment. This parameter gained via the experimental characterization technique was used for an evaluation of the powder properties. The degree of wettability of anhydrous borax powders was measured and compared both after their surfaces were coated with stearic acid and after they were treated with water for a certain period of time in an aqueous environment. The stearic acid coating made the powder hydrophobic and this property was highly preserved after washing.

Journal of Characterization Journal of characterization

Effect of beetroot juice supplementation on the physical and biochemical profiles of induced metabolic syndrome in rat

Beetroot is vegetable containing phytochemical ingredients with potent antioxidant, hypoglycaemic and anti-inflammatory properties. It is key drivers in the pathophysiology of some metabolic syndromes. Its effect on the progress of induced metabolic syndrome has, however, hardly been investigated. Thus, this study aims to determine the effect of beetroot extract on various biophysical components of metabolic syndrome in rat. Following ethical approval, 50 Wister albino rats were used in this study and divided into three groups: Group A: rats were put on a high-fat-high-fructose (HFHF) diet; Group B: rats were put on an HFHF + fresh beetroot extract while group C: rats were the control group and were given a normal diet. The animals’ body weights and fasting blood sugar were taken fortnightly. Five rats from each group were then sacrificed at weeks 4, 8, 12 and 16 and the following parameters were measured: liver volume, fasting lipid profile, hepatic transaminases and blood platelet level. Compared to the HFHF group, beetroot supplementation resulted in a significant attenuation of overall weight gain (56.91% vs. 34.51%; p < 0> 0.05). Beetroot supplementation further ameliorated the thrombocytopenia caused by an HFHF. Beetroot juice supplementation attenuated the attendant effects of induced metabolic syndrome which might contribute towards averting the consequential cardiovascular sequel. Thus, lifestyle modification comprising beetroot intake as a dietary supplementation may alleviate metabolic syndrome and may offer a potential non-medical adjunct in the routine management of metabolic syndrome.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Pdf - attention is all you need

The dominant sequence transduction models are based on complex recurrent or convolutional neural networks that include an encoder and a decoder. The best performing models also connect the encoder and decoder through an attention mechanism. We propose a new simple network architecture, the Transformer, based solely on attention mechanisms, dispensing with recurrence and convolutions entirely. Experiments on two machine translation tasks show these models to be superior in quality while being more parallelizable and requiring significantly less time to train. Our model achieves 28.4 BLEU on the WMT 2014 Englishto-German translation task, improving over the existing best results, including ensembles, by over 2 BLEU. On the WMT 2014 English-to-French translation task, our model establishes a new single-model state-of-the-art BLEU score of 41.0 after training for 3.5 days on eight GPUs, a small fraction of the training costs of the best models from the literature.

Kamal Singh Kamal singh

Professional values, ethics, and professionalism of public relations practitioners

This study explores the influence of education, length of service, professionalism, and ethics on the professional values of public relations practitioners in Malaysia. A total of 427 questionnaires were distributed to public relations practitioners in Malaysia, and 322 questionnaires were returned. The study included 61% female respondents, and 39% male respondents. The study analyzed and identified the influence of professionalism and ethics on professional values of public relations practitioners. Additionally, the study examined whether education and experience influence professional values through professionalism, and code of ethics. Six hypotheses were tested to answer the research questions. The results from this study fully supported the hypotheses indicating that professionalism and ethics had an influence on professional values of public relations practitioners. The results also showed that education influenced both professionalism and ethics, and length of service influenced both professionalism and ethical practice.

Mohammed Fadel Arandas Mohammed fadel arandas

Influence of non-puddled transplanting and residues of previous mustard on rice (oryza sativa l.)

On-farm research was conducted at Gouripur sub-district under Mymensingh district of Bangladesh during the boro (mid November-June) season in 2013-14 and 2014-15 to evaluate the performance of non-puddled rice cultivation with and without crop residue retention. The rice var. BRRI dhan28 was transplanted by two tillage practices, viz., puddled conventional tillage (CT) and non-puddled strip tillage (ST) and at two levels of mustard residues, i.e., no-residue (R0) and 50% residue (R50). The experiment was designed in a randomized complete block design with four replications. There were no significant yield differences between tillage practices and residue levels in 2013-14. But in the following year, ST yielded 9% more grain compared to CT leading to 22% higher Benefit-Cost Ratio (BCR). Retention of 50% residue increased yield by 3% compared to no-residue, which contributed to 10% higher BCR. The ST combined with 50% residue retention yielded the highest grain yield (5.81 t ha-1) which contributed to fetch the highest BCR (1.06).

Svedbergopen

Effects of rapeseed oil (rapus indicus) supplementation on omega-3 fatty acid concentration and carcass characteristics in broiler chicken

Dietary fatty acid composition in broiler influences carcass quality by altering fat deposition and fatty acid profile. Thus, the study was carried out to evaluate the effect of incorporation of rapeseed oil in broiler ration on omega-3 fatty acid concentration of carcass and its traits in broiler chicken. A total of 160 day-old straight run broilers (Vencobb 400) were randomly divided into four treatment groups (G1, G2, G3 and G4) having four replicates of ten chicks each. The basal diets (G1) were prepared to meet BIS (2007) nutrient requirements with palm oil at 1.5, 3, and 4.5 per cent in pre-starter, starter and finisher diets, respectively. The experimental diets were broiler rations prepared with rapeseed oil replacing 25, 50 and 100 per cent of palm oil in G2, G3 and G4 diets, respectively. The diets were fed ad libitum till 6 weeks of age. Six birds from each group were randomly selected and slaughtered on 42nd day to study omega-3 fatty acid concentration of carcass and its characteristics. The crude fat content of breast and thigh muscle was significantly (P<0.05) reduced in the group fed rapeseed oil included diets. However, carcass yield, processing yield and meat to bone ratio of cut up parts was not significantly affected. The colour and pH of breast and thigh muscles were similar among the treatment groups. Omega- 3 fatty acid concentration was significantly (P<0.01) increased in both breast and thigh muscle of G4 group broilers compared to G1 group. Thus, rapeseed oil inclusion in diet significantly increased omega-3 fatty acid concentration and significantly reduced crude fat concentration breast and thigh muscles with no effect on the carcass yield and its quality when included in the diet replacing palm oil at different proportion

SENTHIL MURUGAN Senthil murugan

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