Vinod B
Pyrazole carbaldehyes as antiinflammatory agents-synthesis and in vitro membrane stabilization method
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Pyrazole is a nitrogen containing 5-membered heterocyclic compound containing 3 carbons& 2 nitrogen atoms in the adjacent position of ring structure and is chemically known as 1, 2- diazole. Pyrazole nucleus is present in many pharmaceutically important compounds and intermediates . Majority of anti-inflammatory agents currently employed have GI irritation and enhanced acidity as side effects. As part of our efforts to develop newer and effective anti-inflammatory agents , ten newer pyrazole carbaldehydes were synthesized and evaluated for their anti-inflammatory activity using Diclofenac was the standard. Out of ten compounds synthesized, all compounds exhibited comparable activity with that of the standard.Highest percentage of haemolysis was observed for Pyrazole carbaldehydes with methoxy phenyl groups as substituents. These compounds should be considered for developing as leads for newer & safer anti-inflammatory agents.
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