Power sector reforms in nigeria: implications for agro-manufacturing industry

Abstract The main objective of this paper is to examine the nexus between the reforms that have been carried out in Nigeria concerning the power sector, and the implications of the reforms on the transformation of agro-allied industries. The power sector, no doubt, can be said to have the potential that can propel national development considering the overall importance of energy to the survival of the nation in terms of job creation, industrial development and sustenance as well increase in revenue generation and Foreign Direct Investment opportunities, among others. The unfortunate situation, however, is that in spite of a number of policies enunciated by successive governments aimed at improving on the power sector, not much has been achieved. The multiplier effect of this kind of development has been seen in the widespread epileptic power shortages, downward spiral of efforts towards industrial development drive; unemployment, shortage of national revenue accruing to government coffers, bourgeoning and rising poverty levels, to mention but a few. All of these have further contributed to the growing army of problems currently being witnessed in the country at the moment. This study is a theoretical exposition of the existing works of scholars and experts in the broader field of power sector reforms. The paper is exploratory in structure and method of its investigation. The study concludes and recommends that in view of the prevailing socio-economic circumstances in Nigeria, genuine reforms in the energy sector devoid of political rhetorics will go a long way in mitigating some of the challenges of contemporary times in the power sector

Canice Erunke Canice erunke

Autophagy mechanism, regulation, functions, and disorders

Autophagy is a self-digesting mechanism responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy. In microautophagy cytoplasm material is sequestered through direct invagination to the lysosomal membrane. Whereas in CMA proteins flagged with pentapeptide motif (KFERQ) were selectively degraded through direct translocation into lysosome. Macroautophagy involves the formation of subcellular double-membrane-bound structures called autophagosomes that contain degradable contents of cytoplasm materials and deliver them into lysosomes for breakdown by lysosomal enzymes. The molecular mechanism of autophagy involves several conserved Atg (autophagy-related) proteins. Systems produce modified complexes Atg8-PE and Atg5-Atg12-Atg16 as autophagy regulators. Autophagy is activated in response to diverse stress and physiological conditions. For example, food deprivation, hyperthermia, and hypoxia are mediated by factors like insulin/IGF-1, m-TOR signaling, FOXO transcription factors, and chaperones. The perturbance in autophagy may lead to several types of cancers, myopathies, and neuromuscular disorders. Several autophagy inducers and inhibitors like 3-methyladenine (3-MA), bafilomycin A1, LY294002 (LY), and Velcade have been used to treat disease is an intense field of study.

Kamal Singh Kamal singh

Freedom from open defecation: an empirical study from two adivasi villages of rural areas

This paper found that 35% of Adivasis have health problems, and 73% said that they are getting treatment with RMP. 87% have toilet facility and more than 12% still defecate openly. 18.3% said that they faced different problems at open defecation, and 50% of women not using sanitary napkins. Nearly 90% of respondents wash their hands after toilets and coming from outside of the home. Ten per cent of respondents said that they do not have an awareness of sanitation. Therefore, the study confirmed that the sanitation facilities considerably made the women's dignity and quality of life better in the study area. Moreover, four case studies also focused on open defecation problems in the study area.

B Suresh Lal B suresh lal

"flipping the language classroom:" effects of gamifying instruction in the english language proficiency of filipino esl students

The study aimed to determine the effectiveness of gamifying instruction in the English language proficiency of Grade 8 Filipino ESL students in one University in Bicol, Philippines, that offers Junior High School. The quasi-experimental single pretest-posttest design was used in the study. The researcher-made test which underwent series of validation was given before and after the intervention period to determine the level of English proficiency and level of effectiveness of the games. Statistical treatment was done employing frequency count, T-test and Analysis of Variance (ANOVA). The findings revealed that there was significant difference between the pretest and posttest of the respondents using gamification. Thus, it can be inferred that the games helped in improving the level of English proficiency of the Grade 8 students. The statistical test results disclosed further that the effectiveness of the three games introduced to the students were significantly high. With these findings, it was recommended that language teachers should use gamification as supplementary instructional material in improving the English proficiency of the students.

Darrel Ocampo Darrel ocampo

Educational intervention on knowledge of hypertension and lifestyle/dietary modification among hypertensive patients attending a tertiary health facility in nigeria

Patients’ knowledge of hypertension and treatment has been found to affect health outcomes of hypertension. This study aimed to assess the impact of therapeutic patients’ education on knowledge of hypertension and lifestyle/dietary modification among hypertensive patients in Nigeria. The study was conducted among 317 hypertensive patients randomized into controlled and intervention groups (158 vs 159, respectively) between March 2021 and February 2022. Baseline knowledge of the patients was assessed and intervention was provided for the intervention group with a structured educational program at a baseline and six months. Descriptive data were presented with a frequency table in percentage while the chi-square test and univariate logistic regression were used to determine the association between categorical variables. Out of the total number of 318 patients, 275 completed the study (response rate: 86.8%) with 136 in the control group and 139 in the intervention group. The mean age of the patients was 59.5 (±12.5) and patients > 60 years (49.5%) were the most frequent age category. The baseline knowledge score of hypertension was 9.8 (±2.6) and 9.3 (±2.6) on a scale of 16 points in the control group and intervention group, respectively (P = 0.060) while at six months 11.9 (±2.3) vs 10.8 (±2.4) (P < 0.001) and 12 months 12.6 (±2.5) vs 9.5 (±2.0) (P < 0.001), respectively. Knowledge of lifestyle/dietary modification in the control group and intervention group at baseline was 7.0 (±2.1) and 6.6 (±2.0), respectively, while at six months 7.5 (±1.5) vs 9.9 (±1.3) (P < 0.001) and at 12 months 7.2 (±1.5) vs 10.4 (±1.2), respectively. Marital status, body mass index, and family history of hypertension were associated with knowledge of hypertension and lifestyle/dietary modification (P < 0.001). The educational intervention provided was found to be associated with a significant improvement in knowledge of hypertension and lifestyle/dietary modification. The marital status of the patients, body mass index and family history of hypertension influenced patients’ level of knowledge.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Choleretic and cholagogic effects of anti-cholelithiatic plants

A large number of people suffer from gallstones worldwide, and this problem is now increasing significantly due to malnutrition, changes in living lifestyle, lack of exercise and conditions, i.e. industrialization. Medicinal plants have been used for centuries due to their cultural acceptability, efficacy, safety and fewer side effects than modern synthetic medicines. This review aims to gather information on the plants utilized in various parts of society against gallstones. The information provided is beneficial for ordinary people and the scientific community for further phytochemical, toxicological and pharmacological studies, which may lead to the discovery of new, more effective and safer medicines for gallstones.

Dr. Salman Ahmed Dr. salman ahmed

Finance for decision makers

In their different ownership structures, business enterprises pursue different strategies towards accomplishing their owners’ needs and interests. At the heart of these accomplishments is the generation of sufficient financial returns to cover obligations as they become due and residual incomes for the owners. It is doubtless that without a grip of financial stability, the survivability of for-profit organizations becomes bleak. Financial management plays and instrumental role in this case. The generation of sufficient information for decision making for the business and investors alike is integrally critical in shaping the progression of the business enterprise. While businesses provide financial statements according to prevailing laws and accounting standards to the public for their consumption in decision making, they are further needed to be accountable to them regarding their performance and investors’ engagements, especially considering that investors are foundational sources of capital for organizational operations.

Zamzam Abdelazim Zamzam abdelazim

Isolation and screening of potential dye decolorizing bacteria from textile dye effluents in tamil nadu, india

The present study reveals that the enriched aerobic cultures of indigenous microbes can be used successfully for decolorizing dye effluents. Physico-chemical analysis of dye effluent revealed high load of pollution indicators. Textile dye effluent and contaminated soils were collected and analyzed for selection of suitable bacteria for dye degradation. The residual bacterial load was found to be in the range of 108 cfu/mL. Six bacterial strains viz., two species of Bacillus, two species of Klebsiella,, one species each of Planococcus and Micrococcus luteus were isolated. The best two dye degraders namely species of Planococcus and Bacillus were further optimized for the effect of carbon and nitrogen source, pH, temperature and percentage of inoculum. The optimized conditions for both the isolates of Planococcus sp. and Bacillus sp. were used in bio-decolorization studies of textile effluent. More than 50% of decolorization was achieved within 4 d of incubation. After 6 d of incubation, decolorization was achieved above 80%. The isolates Planococcus sp. and Bacillus sp. exhibited maximum decolorization ability at pH between 5-8 and temperature 37C. Moreover, 10% (v/v) inoculums, glucose and peptone as carbon and nitrogen sources were found to be the optimum for decolorization. Both the isolates showed highest decolorization percentage of Coractive Blue 3R dye effectively during optimization and more interestingly showed consistent decolorization of textile dye throughout the study.

Dr. SARANYA DEVI K Dr. saranya devi k

Implementasi pembelajaran fiqih materi sholat dengan media audio visual di madrasah ibtidaiyah

This research was conducted to form students to be more disciplined in maintaining time, especially in prayer, as well as to strengthen aqidah and increase the worship of students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah. The focus of this research is: 1) How to plan the prayer chapter of fiqh learning through audio-visual media for students of Class IV Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung, 2) How to implement the prayer chapter of fiqh learning through audio-visual methods for students of Class IV Madrasa Ibtidaiyah Salafiyah Syafi 'iyah Ajung, 3) How is the evaluation of fiqh learning in the prayer chapter for fourth grade students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung. This research uses qualitative research with descriptive qualitative research. Determination of research subjects in this study was carried out purposively. Data collection techniques used observation, interviews, and documentation. Analysis of the data, the researcher used the data analysis model of the Miles, Huberman, and Saldana models including: Data Condensation (Condensation), Data Presentation (Display), Conclusions Drawing. The validity of the data in this study used source triangulation and technical triangulation. The results showed that: 1) The use of audiovisual media was very relevant in learning fiqh in the prayer chapter 2) Active, innovative, creative, effective and fun learning made students enthusiastic and enthusiastic in learning and not boring. 3) the completeness of learning facilities and infrastructure is very influential in the evaluation stage including summative evaluation and formative evaluation, input evaluation, process evaluation and output evaluation. Penelitian ini dilakukan untuk membentuk peserta didik lebih disiplin dalam menjaga waktu khususnya dalam shalat, serta memantapkan aqidah dan meningkatkan ibadah peserta didik Madrasah Ibtidaiyah Salafiyah Syafi’iyah. Fokus penelitianini adalah: 1) Bagaimana Perencanaan Pembelajaran fiqih bab sholat melalui media audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 2) Bagaimana Pelaksanaan pembelajaran fiqih bab sholat melalui metode audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 3) Bagaimana evaluasi pembelajaran fiqih bab sholat bagi peserta didik kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung. Penelitian ini menggunakan penelitian kualitatif dengan jenis penelitian kualitatif deskriptif. Penentuan subyek penelitian dalam penelitian ini dilakukan secara purposive.Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data, peneliti menggunakan model analisis data model Miles, Huberman, dan Saldana meliputi: Kondensasi Data (Condensation), Penyajian Data (Display), Penarikan Kesimpulan (Conclusions Drawing). Keabsahan data dalam penelitian ini menggunakan triangulasi sumber dan triangulasi teknik.Hasil penelitian menunjukkan, bahwa: 1) Penggunaan media audiovisual sangat relevan dalam pembelajaran fiqih bab sholat 2) Pembelajaran aktif, inovatif, kreatif, efektif, dan menyenangkan membuat peserta didik semangat dan antusias dalam belajar serta tidak membosankan. 3) kelengkapan sarana dan prasarana pembelajaran sangat berpengaruh pada tahap evaluasi meliputi evaluasi Sumatif dan evaluasi Formatif evaluasi input, evaluasi proses dan evaluasi output.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Comparative analysis of boiler efficiency between commercial sawdust briquettes and biomass briquettes

During this research work, a theoretical study was done to compare the boiler efficiency by using two different fuels, i.e. commercial sawdust briquette and biomass briquette prepared using 850 μ coconut leaves, with sawdust as the binder. For preparing the biomass briquettes to leave of coconut were gathered, dried, milled, and sieved and sizes of 850μ were selected. The sized coconut leaves were then mixed in the company of sawdust that worked as a binder in 1:2 ratios, and compressed by means of a piston-type briquette machine, which was fabricated for the same. Ultimate and proximate analyses were carried out on the biomass briquette to determine their various compositions. Results from analysis were used to calculate the boiler efficiency by the indirect method using Indian Standard Boiler Efficiency IS 8753. Results from the analysis showed that boiler efficiency by indirect method for commercial sawdust briquette is 68.80% and boiler efficiency by indirect method for coconut leaves of 850μ, with sawdust as a binder is 61.17%. The reason for higher boiler efficiency for commercial sawdust briquette is due to its higher calorific value (4451.37KCal/gm) when compared to that coconut leaves briquette made from 850μ size with sawdust as a binder (3672.45KCal/gm). From proximate and ultimate analysis, the results showed a reduction in ash content percentage, moisture content, and rise in volatile matter percentage, when the comparison was along with the marketable sawdust briquette, which is of considerable significance. Additional properties akin to the percentage of hydrogen, fixed carbon, sulfur, nitrogen, and oxygen were roughly the same as that of the commercially available sawdust briquettes. After calculating the boiler efficiency of the two biomass briquettes, coconut leaves with sawdust as binder exhibited the most optimistic trait and as it is more easily and readily available, thus making it more economically viable.

Dr.deepak kb

Effect of arbuscular mycorrhizal fungi in the management of black bundle disease of maize caused by cephalosporium acremonium

Three species of arbuscular mycorrhizal fungi (Glomus fasiculatum, Glomus mossae and Acaulispora laevis) were used as bio-agents to manage black bundle disease of maize caused by C.acremonium. The results revealed that colonization of arbuscular mycorrhizal fungi in root system of the host reduce the percentage of disease incidenceconsiderably.In the pots inoculated with G. fasiculatum no disease incidence (0.0%) was recorded whereas, in the pots inoculated with A. leavis and G. mossae 16.66 % of disease incidence was recorded and the pots treated with pathogen shows 66.66% of disease incidence compare to control. Among the three bio-agents, Glomus fasiculatumproved to be more effective in managing the disease followed by G.mossae and A. laevis. In addition, all the three AM fungi enhanced the plant growth when they are used alone as inoculum as compared to dual inoculation with the C. acremonium and overall control. This clearly suggests that, AM fungi if used, can serve dual purpose. It can be used as bio-control agent as it shows negative antagonistic interaction soil borne plant pathogens and used as growth promoter because of the ability to supply macro and micro nutrients to the host plants.

Veerabhadraswamy AL Veerabhadraswamy al

Implementation of javanese krama learning in improving students' ability to speak politely at mima 35 nurul ulum ambulu

This study examines Javanese Krama's learning in improving students' ability to speak politely at MIMA 35 Nurul Ulum Ambulu. This research approach is a descriptive qualitative approach, and the type of research used is phenomenology. Data collection techniques using interviews, observation, and documentation. While the data analysis using the model of Miles, Huberman, and Johnny Saldana consists of data condensation, data presentation, and conclusion. The results of this study are 1) Planning for learning the Javanese Krama language to improve the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: the teacher prepares a Learning Implementation Plan, prepares to memorize material for the Javanese Krama language vocabulary for students. 2) Implementation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: opening, core, and closing activities. Then the habit of using Javanese manners during learning hours and outside the classroom. 3) Evaluation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: in the classroom using daily questions, PTS and PAS. Meanwhile, habituation outside of learning hours is by assessing students' speech and manners. 4) The implications of learning Javanese Krama in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu have a positive impact on students becoming accustomed to using Javanese Krama when communicating with teachers both in attitude and speech.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Professional values, ethics, and professionalism of public relations practitioners

This study explores the influence of education, length of service, professionalism, and ethics on the professional values of public relations practitioners in Malaysia. A total of 427 questionnaires were distributed to public relations practitioners in Malaysia, and 322 questionnaires were returned. The study included 61% female respondents, and 39% male respondents. The study analyzed and identified the influence of professionalism and ethics on professional values of public relations practitioners. Additionally, the study examined whether education and experience influence professional values through professionalism, and code of ethics. Six hypotheses were tested to answer the research questions. The results from this study fully supported the hypotheses indicating that professionalism and ethics had an influence on professional values of public relations practitioners. The results also showed that education influenced both professionalism and ethics, and length of service influenced both professionalism and ethical practice.

Mohammed Fadel Arandas Mohammed fadel arandas

Anti-emetic activity of some aromatic medicinal plants

Anti-emetic activity Of four aromatic medicinal plants (Curcuma caesia Roxb., Piper longum Linn., Piper nigrum Linn., and Syzygiunt aromaticum (Linn.) Merr. & Perry) was studied in chicks. The ethanol extracts of these plants were administered at 150 mg/kg BW orally. All the extracts showed a significant (P < 0.05) decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg /kg BW. Domperidone was given at 100 mg/kg as a reference drug.

Dr. Salman Ahmed Dr. salman ahmed

Covid-19 - pushes marketers to sell differently to global millennials in emerging markets

CoronaVirus’ is a hard hit on both Millennial consumers and marketers. It forced consumers and marketers to do the usual activities of buying and selling differently. Panic buying and herd mentality was widely noticed among millennials. Their unusual buying behavior which reflects behavior during a crisis is highly influenced by environmental stimuli. From this study, it is found that there has been a significant buying behavioral shift of global millennials in emerging markets (BRIC – Brazil, Russia, India, China; CIVETS – Columbia, Indonesia, Vietnam, Egypt, Turkey, South Africa). It is evident that the initial marketing attempts of marketers failed during COVID-19 due to the lack of understanding of the significance of environmental and marketing stimuli in consumers’ purchase decisions. This study brings out the various positive substantial changes brought about through internetization in marketing goods and services to millennial customers during the pandemic. The pandemic enabled a rapid digital revolution in buying and selling using digital/online platforms. The study suggests the application of the Black Box Model by marketers in marketing and selling decisions. The Internet has been the most important tool used by customers and sellers to access what they need. This study is useful to marketers and upcoming entrepreneurs to understand that it is the consumer’s buying behavior that triggers and pushes marketers to sell differently.

Sridevi Sridevi

Got faith?-an in-depth analysis and review of five faith-based prisoner reentry programs in florida

In the United States, prisoner reentry programs are a necessity to re-integrate back into society and are of two types: Faith and Non-Faith. With increased emphasis placed on reforming the criminal justice system policies due to Black Lives Matter and other non-profits actively working to change the system from the outside, reentry programs are having a resurgence of interest for effective public policy. There are significant barriers for major policies at the state, local, and federal to be alleviated, nevertheless, our research wanted to consider the effectiveness of five faith-based, male-only reentry programs in central Florida. Small focus groups were utilized to better understand the concerns and issues returning inmates faced in the program as well as when returning to society. Reentry participants were found to have high confidence in the success of their participation in their faith-based program’s efforts on their personal and family growth.

International Journal of Business and Social Science Research International journal of business and social science research

Tetra-block: ultrasound femoral, lateral femoral-cutaneous, obturator, and sciatic nerve blocks in lower limb anesthesia: a case series

The gold standard anesthesiologic procedure for urgent femur fracture surgery is Spinal Anesthesia. It is not always feasible because of patients' severe comorbidities and difficulties in optimizing drug therapy in the appropriate time frame such as discontinuation of anticoagulant drugs. The use of four peripheral nerve blocks (tetra-block) can be a winning weapon when all seems lost. We present, in this case series, three Caucasian adult femur fractures (an 83-year-old woman, a 73-year-old man, and a 68-year-old woman) with different and major comorbidities (cardiac or circulatory disorders on anticoagulants therapy that were not discontinued on time; breast cancer and others) underwent the same anesthesiologic approach in the urgent setting. Ultrasound peripheral nerve blocks, that is femoral, lateral femoral cutaneous, obturator, and sciatic with parasacral approach were successfully performed in all patients who underwent intramedullary nailing for intertrochanteric fracture. We evaluated the adequacy of the anesthesia plane, postoperative pain control with the VAS scale, and the incidence of postoperative side effects. Four peripheral nerve blocks (Tetra-block) can be alternative anesthesiologic management in urgent settings, in patients where drug therapy cannot be optimized, as in antiplatelet and anticoagulant therapy.

Dario Cirillo Dario cirillo

Selection of potential isolates of plant growth promoting rhizobacteria (pgpr) in conferring salt tolerance under in vitro

Salinity is a major environmental stress which has been studied extensively and has its impact on agriculture in the past, present and future. The global importance of salt affected soils can be explained by their wide distribution on all continents covering about 10% of the total land surface. At present, there are nearly 954 million ha of saline soils on earth’s surface. It is extremely difficult to quantify the social and economic costs of salt prone land and water resources. Plant Growth Promoting Rhizobacteria (PGPR) is a group of bacteria that actively colonize plant roots and increase plant growth and yield. They play an important role within the interaction between soil and plant. As plants grow on marginal soils such as saline soils, the importance of the rhizobacteria increases as they mobilize nutrients and provide tolerance ability to the plants. In the present study, an attempt was made and isolated 51 PGPR isolates (Phosphate Solubilizing Bacteria–18; Azotobacter spp.-16 and Azospirillum spp.-17) from different salt affected areas in Tamil Nadu and Puducherry. All the isolates were screened for their efficacy against different sodium salts namely sodium chloride, sodium citrate and sodium sulphate. It was observed that the absorbance of the culture broth grown in salt stress to sodium chloride decreased with increasing concentration of the salt. Similarly decrease in growth pattern in terms of the absorbance was also observed in salt stress to sodium citrate and sodium sulphate.

Dr. SARANYA DEVI K Dr. saranya devi k

Influence of demographic and socio-economic factors on locus of control on residents of select suburbs in mumbai city

The orientation he/she chooses has a bearing on his/her long-term success. This orientation is known as your "locus of control." Its study dates back to the 1960s, with Julian Rotter's investigation into how people's behaviours and attitudes affected the outcomes of their lives. Locus of control has been defined as the degree to which an individual perceives having control over the environment (Rotter, 1966). According to Rotter (1975), there are two types of control, internal and external, which anchor a continuum that approximates a normal distribution. People are said to have an internal locus of control when they believe reinforcements are contingent upon their own behaviour or stable personal characteristics. External locus of control results when people believe that reinforcements are due to luck, fate, or powerful others outside of their control. Current study focuses on investigating the influence of demographic variables (age, gender, education level), marital status and socio economic status (occupation, income) on the level of internal/ external locus of control with the help of data collected from residents (aged between 20 and 50) of a select suburbs in Mumbai city. On analysing the data so collected, it is found that age has a major influence on an individual’s level of internal locus of control.

Nandini Nandini

Occurrence of hypopituitarism in tunisian turner syndrome patients: familial versus sporadic cases

Objective: To explore unusual association between Turner Syndrome (TS) and Hypopituitarism in a Tunisian cohort. Methods: We reported 6 patients with TS associated to Hypopituitarism, including three familial cases except the fourth sister who showed only a TS phenotype. Biochemical analysis, resonance magnetic imaging and cytogenetic analyses were performed. Results: The average age of our patients was 17.2 years (11-31 years). They were all referred for short stature and pubertal delay, except for the fourth sister who presented spontaneous puberty with the integrity of the pituitary axis and the presence of an X ring chromosome. Karyotype analysis showed monosomy in 3 cases and a mosaic TS in the 3 remaining cases, including one patient with abnormal X chromosome structure. Somatotropic and corticotropic deficiencies were confirmed in 2 sporadic cases while the gonadotropic and thyrotropic axes were spared. In contrast; familial cases were consistently affected by the integrity of the corticotropic axis. MRI showed pituitary hypoplasia in all familial cases and pituitary stalk interruption syndrome in only one sporadic case. No correlation was found between the chromosome formula and the anterior pituitary involvement. Conclusion: Co-segregation of congenital Hypopituitarism with pituitary hypoplasia and X chromosome aberrations could imply a molecular anomaly of transcription factors responsible for the differentiation and development of pituitary cells such as PROP1, POUF1, Hesx1, Lhx3, Lhx4. The etiopathogenic link between X chromosome abnormalities and the occurrence of Hypopituitarism remains unclear; however, the progress of molecular biology may clarify the interrelation between transcription factors and sex chromosome segregation abnormalities.

Mariam moalla Mariam moalla

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