The concept of knowledge and the process of knowledge sharing in ethnic minority microbusinesses remain neglected in contemporary debates even if their role for economic development is recognized. Drawing on a culturalist view, we explore how knowledge is defined and shared in a local niche market. Thematic analysis of semistructured qualitative interviews with 32 owner managers and 11 employee-managers reveals that, contrary to studies on larger firms, local knowledge creation and sharing narrowly based on ethnic strengths are valuable sources of competitive advantage. Our study has implications for researchers, policymakers, and practitioners in exploring, supporting, and integrating ethnic minority microbusinesses.
Wilsons disease is a rare inherited disorder which is characterized by impaired copper excretion which leads to excessive deposition of copper in many tissues and organs like brain, liver, and eye. This is also characterized by Kaiser-Fleischer ring, low serum ceruloplasmin levels and elevated urinary copper excretion [1]. A 26year male patient came to the neurology department with chief complaints of involuntary tremors of both hands and difficulty in walking in the last one month associated with swaying to one side in the last 20 days. On examination the patient is having Kaiser-Fleisher ring positive and upon further investigation Magnetic resonance imaging brain was performed which revealed the features in favor of Wilson’s disease. And for this condition the patient is treated with chelating agents and benzodiazepines. Key words: Wilson’s Disease, Kaiser- Fleisher ring, Chelating agents
The Atlas of Shear Zone Structures in Meso-Scale illustrates the morphological characteristics of shear zones within the Himalayas that have been gathered by the author’s intensive field observations over the last decade. The book deals with various shear zone-related structures, produced in brittle and/or ductile regimes. The shear sense indicators and associated microstructures are also described.
In the article first assesses the potential distribution in Eurasia of Neodiprion abietis (Harris, 1841) first time assessed. The species id a widely distributed in North America fir and spruce defoliator, intercepted in 2016 in the Netherlands. Analysis of the literature data on the known distribution and host plants of the species is given. Insufficient data for ecological modeling is shown, which causes a high degree of uncertainty in assessment of potential range. The results of modeling the potential range of the species using several algorithms are presented. The reliability of the obtained models and the importance of bio-climatic environmental variables for species distribution are assessed.
This study aims to assess tourists‟ perceptions towards quality tourism services provided at Petra historical site, and to measure tourist satisfaction by examining the impact of quality tourism product on overall tourist satisfaction. In this study, four hypotheses were developed are proposed a study model. The empirical data were collected from tourists via a survey that yielded 180 usable questionnaires, these data were analysed using a series of multiple regressions to determine the relationship between service quality and tourist satisfaction. The findings confirmed that service quality directly impacted tourist satisfaction throughout destination facilities, destination accessibility and destination attraction. As a result, this study argued that there is a significant impact of the service quality on tourist satisfaction, and therefore service quality plays an important role in tourism by increasing the level of tourist satisfaction. The results in this study supported the evidence that there are positive impacts of components of tourism product on tourist satisfaction. This study provided some theoretical and managerial implications based on the findings to academicians and tourism sector, the researcher presented recommendations for further studies and he discussed the main limitations in this study
Along with computer technology, the demand of digital image processing is too high and it is used massively in every sector like organization, business, medical etc. Image segmentation enables us to analyze any given image in order to extract information from the image. There are numerous algorithm and techniques have been industrialized in the field of image segmentation. Segmentation has become one of the prominent tasks in machine vision. Machine vision enables the machine to vision the real world problems like human does and also act accordingly to solve the problem so it is utmost important to come up with the techniques that can be applied for the image segmentations. Invention of modern segmentation methods like instance, semantic and panoptic segmentation have advances the concept of machine vision. This paper focuses on the various methods of image segmentation along with its advantages and disadvantages.
Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .
This chapter discusses the effects of stimuli that combine sexuality and aggression. It outlines the debate over aggressive versus nonaggressive pornography and discusses the frequency of aggressive pornography and bases for concern. Aggressive pornography and sexual arousal is explored in the chapter wherein initial findings, victim's responses, individual differences, context of assessment, and conclusions are discussed. The chapter reviews the effects of aggressive pornography on responses other than aggression wherein it has discussed about changes in sexual responsiveness, fantasies, and perceptions and attitudes. The effects of aggressive pornography on aggression are explored in the chapter wherein research findings are discussed in detail and summary of effects on aggression, theoretical analyses, and the construct validity of assessing aggression are also described. The data across the laboratory and field experiments discussed in this chapter raise a variety of theoretical and empirical issues that should be addressed in future research. Particularly noteworthy are questions concerning stimuli, subject, and setting characteristics.
This article addresses the implementation of the new generalized (G'∕G)-expansion method to the Caudrey–Dodd–Gibbon (CDG) equation and the Lax equation which are associated with the fifth-order KdV (fKdV) equation. The method works well to derive a variety of standard and functional closed-form wave solutions with distinct physical structures, such as, soliton, kink, periodic soliton, and bell-shaped soliton solutions. The solutions obtained using this method are useful and adequate than other methods. In order to understand the physical aspects and importance of the method, the attained solutions have been simulated graphically. The extracted results definitely establish that the new generalized(G'∕G)-expansion method is an effective mathematical tool to work out new solutions to different types of local nonlinear evolution equations emerging in applied science and engineering, but this method is not effective in solving nonlocal equations.
Overall, disability refers to a physical or mental state that impairs an individual's ability to function in daily life. It suffices to say that disability is a medical-social issue that affects both the family and the nation. In a country like India, where girl children are frequently stigmatized as a burden on society, the condition of girl children with special needs is frequently subject to carelessness, lack of compassion, and illiteracy. Though the situation has improved slightly since the introduction of inclusive education, the situation is critical for tribal girl students with special needs. In a fragile socioeconomic environment, tribal girls are already vulnerable to high dropout rates, early marriage, and an ignorant attitude from family members, but the situation is pitiful for tribal girls with special needs. The tribal girl students with special needs suffer quadruple discrimination of being female, being disabled, being ST, and being socio-economically backward. Here, intervention through artificial intelligence (AI) and AI-assisted devices can be critical in overcoming the barriers encountered by tribal girl students with special needs in the process of inclusion and development
Social engineering is a method of information security that allows for system or network access. When victims are unaware of techniques, models, and frameworks to prevent them, social engineering attacks happen. In order to stop social engineering attacks, the current research describes user studies, constructs, assessment, concepts, frameworks, models, and techniques. Sadly, there isn't any specific prior research on mitigating social engineering attacks that thoroughly and efficiently analyzes it. Health campaigns, human security sensor frameworks, user-centric frameworks, and user vulnerability models are examples of current social engineering attack prevention techniques, models, and frameworks. Guidance is required to examine cybersecurity as super-recognizers, possibly acting as police for a secure system, for the human as a security sensor architecture. This research aims to critically and systematically analyze earlier material on social engineering attack prevention strategies, models, and frameworks. Based on Bryman & Bell's methodology for conducting literature reviews, we carried out a systematic review of the available research. Using a protocol, we discovered a novel strategy to stop social engineering assaults in addition to approaches, frameworks, models, and assessments, based on our review. We discovered that the protocol can successfully stop social engineering assaults, including health campaigns, the susceptibility of social engineering victims, and co-utile protocol, which can control information sharing on a social network. This comprehensive evaluation of the research is what we're presenting in order to suggest safeguards against social engineering assaults.
Dans toute société, l’homme nait, grandit et meurt. Ces étapes marquant la vie de l’être humain sont des passages obligés dans le parcours existentiel de tout être vivant. Si le premier et le deuxième éléments sont des moments de réjouissance pour les parents, les amis et la famille, le troisième par contre attriste, alite et est parfois source de discorde et de séparation des membres d’une même communauté. A la mort d’un parent, des soutiens de toutes natures viennent de toute part. Ces soutiens sont la manifestation de la solidarité au sein de nos communautés. Des chansons sont scandées avant, au cours et après l’inhumation. Comme on le constate dans plusieurs communautés linguistiques, ces chansons funéraires assument, dans la société, des fonctions diverses. Cette étude qui analyse quelques chansons aussi bien sur le plan social que linguistique, vise à montrer la valeur de la chanson et le sens qu’elle véhicule dans la communauté ajatado prenant en compte le Bénin, le Togo, le Ghana et le Nigéria sans oublier ses différentes fonctions dans la société.
Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised by agranulocytosis as adverse effect. Subsequent to nonenzymatic hydrolysis, the primary metabolic step is N-demethylation of 4-methylaminoantipyrine (4-MAA) to 4-aminoantipyrine (4-AA). The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating this reaction. This study identified the relevant CYP using virus expressed isolated human CYP, human liver microsomes and rat liver microsomes with chemical inhibition studies. The substrate of 4-methylaminantipyrine was employed at six different concentrations (25, 50, 100, 400, 800 and 1200 µmol per l) with varying concentrations of selective inhibitors of CYP1A2 (furafylline, fluvoxamine), CYP3A4 (ketoconazole), CYP2A6 (coumarin), CYP2D6 (quinidine), CYP2C19 (omeprazole, fluvoxamine, tranylcypromine), CYP2C9 (sulphaphenazole) and CYP1A1 (alpha-naphthoflavone). 4-MAA and 4-AA were analyzed by HPLC and enzyme kinetic parameters (Km and Vmax) were determined by regression (Sigma plot 9.0). The N-demethylation of 4-MAA by microsomes prepared from baculovirus expressing human CYP was pronounced with CYP2C19. Intrinsic clearance of the most active enzymes were 0.092, 0.027 and 0.026 for the CYP enzymes 2C19, 2D6 and 1A2, respectively. Metabolism by human liver microsomes was strongly inhibited by fluvoxamin, omeprazole and tranylcypromine (IC50 of 0.07, 0.07 and 0.18, respectively) but with coumarin, sulphaphenazole, ketoconazole, moclobemid, quinidine alpha-naphthoflavone and furafylline were 0.79, 1.20, 1.36, 1.44, 3.46, 4.68 and 8.41, respectively. The enzyme CYP2C19 apparently has an important role in N-demethylation of 4-methylaminoantipyrine which should be further analyzed in clinical studies and which may also be interesting concerning the agranulocytosis.
Mediterranean journal of pharmacy and pharmaceutical sciences
The current study is carried out to evaluate the antiemetic activity of methanol extracts of five leguminous plants leaves viz., Cassia siamea Lamk., Cyamopsis tetragonoloba Taubert., Delonix regia Rafin., Samanea saman Merr. and Vigna trilobata Verdc. at a dose of 150 mg/kg body weight orally, using a chick emesis model. Emesis was induced in male chicks by the oral administration of copper sulphate (50 mg/Kg body weight). The antiemetic activity was determined by calculating the mean decrease in the number of retching as compare with the control. All the extracts showed antiemetic activity when compared with standard drug chlorpromazine (150 mg/kg body weight orally). Among all extracts, Delonix regia showed the highest (96.74%) and Cassia siamea lowest (18%) antiemetic activity.
The application of clinical pharmacokinetic is the responsibility of all pharmacists providing pharmaceutical care. An appropriately applied clinical pharmacokinetic is expected to result in improved patient outcomes: decreased mortality, reduced length of treatment, reduced length of hospital stays and cost-savings. Data on the extend of pharmacokinetic application in Libyan hospitals remain scarce but available subjective evidence suggests that services related to clinical pharmacokinetic are mostly provided and performed by professionals other than clinical pharmacists. To explore the training background and perceptions of pharmacists on the pharmacokinetic course contents they received during their undergraduate pharmacy programs. Also, to determine the attitudes and barriers experienced by the pharmacists when applying pharmacokinetic principles in their current practice. This is a cross-sectional, descriptive study that was conducted between July 2018 and November 2019 using a self-administered survey. The study targeted hospital pharmacists practicing in different hospitals in Libya. A total of 104 pharmacists completed the questionnaire and submitted it back. The majority of participants learned pharmacokinetic courses as a mandatory course during undergraduate courses 81.0% with 37.0% selecting that course was taught as a separate course or courses. Around 80.0% of the participants agreed or strongly agreed that pharmacokinetic courses received in undergraduate studies are useful in pharmacy practice with over 75.0% of the participants agreeing or strongly agreeing on relevance of those course to their current clinical practice. About 40.0% of the participants described their current skills in allowing optimal patient care as can be better. Different barriers were highlighted by the participants to allow sufficient clinical pharmacokinetic practice including lack of sufficient information, lack of awareness of pharmacists’ role and skills in applying clinical pharmacokinetic by other pharmacists and by other health care providers. Thus, this study shows that most practicing pharmacists showed a positive attitude of current pharmacokinetic practice and to the impact of their undergraduate studies on their successful practice. However, they have clearly addressed the room for improvement.
Mediterranean journal of pharmacy and pharmaceutical sciences
Abstract: Objective: To evaluate the Antiparkinson activity of Allium sativum in Haloperidol induced Parkinson‟s disease in mice. Method: Parkinson‟s disease was induced by administering haloperidol (2.0 mg/kg i.p.) Daily for a week. The mice were divided into 5 group (n=6). Group II received haloperidol (2mg/kg body weight).Group III received combination of levodopa and carbidopa (100mg+ 10mg/kg by i.p along with haloperidol) and Group IV and V received Allium sativum extract (200 and 400mg/kg by p.o), respectively for 7 days along with haloperidol. To evaluate the antiparkinson effect of Allium sativum, catalepsy bar test, rotarod test, hang test and horizontal bar test were used. One way ANOVA was used to test statistical significance followed by Bonferroni multiple comparison tests .Results: Allium sativum extract (200 and 400mg/kg by p.o) was found to decrease the duration of catalepsy significantly (P<0.001) in catalepsy bar test as compared to haloperidol group, and significantly increases (P<0.001) fall off time in, rotarod test, hang test and horizontal bar test respectively as compared to haloperidol group. Conclusion: The result of the present study conclusively shows the Antiparkinson‟s activity of Allium sativum in haloperidol induced Parkinson‟s disease in mice.
The orientation he/she chooses has a bearing on his/her long-term success. This orientation is known as your "locus of control." Its study dates back to the 1960s, with Julian Rotter's investigation into how people's behaviours and attitudes affected the outcomes of their lives. Locus of control has been defined as the degree to which an individual perceives having control over the environment (Rotter, 1966). According to Rotter (1975), there are two types of control, internal and external, which anchor a continuum that approximates a normal distribution. People are said to have an internal locus of control when they believe reinforcements are contingent upon their own behaviour or stable personal characteristics. External locus of control results when people believe that reinforcements are due to luck, fate, or powerful others outside of their control. Current study focuses on investigating the influence of demographic variables (age, gender, education level), marital status and socio economic status (occupation, income) on the level of internal/ external locus of control with the help of data collected from residents (aged between 20 and 50) of a select suburbs in Mumbai city. On analysing the data so collected, it is found that age has a major influence on an individual’s level of internal locus of control.
The choice of the study design is a major determinant of scientific quality and clinical value of a research study. To select an appropriate study design is a perplex task for novice as well as veterans in research. AYUSH systems of medicines have evidence database showing the effectiveness in a wide range of clinical conditions, yet improving the quality of trials by well- designed studies is indispensable to demonstrate widespread utility on more scientific grounds. This article describes the structured classification of research designs done on the basis of a selective literature search concerning medical research. The study design and type that can best answer the particular research question at hand must be determined not only on a scientific basis, but also in view of the available resources, ethical issues and practical feasibility of study.
The article analyzes the main problems of making an assessment of public administration activities, gives important question and makes main ways of experiences of assessing criteria of public administration. This the article is also devoted to the analysis of the essence of efficiency and quality of public administration in the world and studies the main conceptual models of efficiency of public administration, the definition of types of efficiency and identification of the main problems when forming criteria for evaluation of efficiency and quality of the government
Vitamin C is associated with history of the cause of the ancient hemorrhagic disease scurvy. Vitamin C is an essential nutrient with important antioxidant properties. It is required by the body for normal physiological function. The body cannot synthesize vitamin C, it is present in nature through foods and other natural sources and it exists as a nutritional food supplement. The antioxidant activity of vitamin C protects the body from free radical damage. Vitamin C is essential for the development and maintenance of connective tissues. It is used as therapeutic agent in many diseases and disorders. Vitamin C plays an important role in several metabolic functions, as the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin, and the conversion of cholesterol to bile acids. Vitamin C supplementation resulted in a significant increase in vitamin C levels in populations; its high intake is associated with positive effects on cardiovascular risk factors. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight infections. It has an important role in bone formation, wound healing and the maintenance of healthy gums. There is profound beneficial effect of vitamin C in respect to human diseases as cancer, atherosclerosis, diabetes, neurodegenerative disease and many metal toxicities. Several vitamin C analogs have been produced as anticancer and antioxidant activity. Vitamin C is useful if it is used as adjuvant therapy for several chronic diseases. Thus, this review summarizes the importance of vitamin C in the body’s physiology and biochemistry, in addition, the different mechanisms that vitamin C is implicated to treat different acute and chronic diseases. Future exploration should pay attention to chronic disease management by vitamin C.
Mediterranean journal of pharmacy and pharmaceutical sciences
College Of Nursing, University Of Raparin, Rania, Sulaymaniyah, Kurdistan Region, Iraq
Maharanai Laxmibai Government Paramedical Training College Jhansi Uttar Pradesh India
Adarsh Vijendra Institute Of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur