A simple, rapid, sensitive reversed-phase high-performance liquid chromatography method was developed and validated for simultaneous measurement of albendazole and praziquantel with an internal standard, simvastatin, at single wavelength of 225 nm. Chromatographic separation was performed on an Enable C18 column (250 mm × 4.6 mm, 5 μm: Spinco Biotech Pvt Ltd) and a mobile phase consisting of acetonitrile:water (60:40, v/v) with 10% orthophosphoric acid to adjust the pH to 3.2, at a flow rate of 1.0 ml/min. The calibration curve was linear (r2 ≥ 0.999) over the concentration range 0.05–8.0 μg/ml. The concentrations of simvastatin was 1.0 μg/ml. The limit of quantification was 0.05 μg/ml for both albendazole and praziquantel. No interference was found by the excipients in the synthetic mixture. The proposed methods were validated as per International Conference on Harmonisation guidelines for linearity, accuracy, precision and robustness for estimation of albendazole and praziquantel in bulk and in a synthetic mixture, and the results were found to be satisfactory.

Prasanna pradhan

Vigna aconitifolia (Jacq.) Marechal. (Papilionaceae) is a medicinally important plant used for treating different diseases, especially dermatological disorders. Alkaloids, phenols, flavonoids, and phytic acid have been reported in this plant. Vigna aconitifolia also exhibits antioxidant, antidiabetic, and hypocholesterolemic activities. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

Before the start of the SARS-CoV-2 (COVID-19) pandemic, the whole environment around us had been deemed very toxic to breathe in due to the amount of greenhouse gases that had been emitted over the centuries. The Earth faced rising temperatures, which in turn led to the melting of glaciers and rising of sea levels. Environmental degradation was happening fast due to the depletion of resources such as air, water and soil. But after the coronavirus lockdown (Talabandi) commenced, there have been changes in the environment. The lockdown still has a huge impact on people in India too. The halt of industrial production and traffic resulted in cleaner air and rivers. In India the first phase of the nationwide lockdown that began on March 24 followed by enforcement of a series of regulations had some evidences that the COVID-19 curve is flattening in the country's COVID-19 affected regions. There was a good chance Prime Minister Narendra Modi extended the lockdown (Talabandi) four times that ended on (Phase 1 (24 March-14 April)., Phase 2 (15 April-3 May)., Phase 3 (4 May-17 May) & Phase 4 (18 May-31 May). The paper focuses on different aspects of environmental impact due to SARS-CoV-2 in India.

Rina kumari

Poor water quality and lack of access to improved sanitation continue to pose a significant threat to human health. The burden of disease analysis suggests that lack of access to safe water supply, sanitation and hygiene is the third most significant risk factor for poor health in developing countries with high mortality rates. Diarrhoea is the leading disease associated with unsafe water supply, sanitation and hygiene and is responsible for the deaths. The study observed that out of the 150 respondents, 37% are 31-40 years, followed by 20-30 years with 32%. 130 (86.7%) respondents have got married, and 61% of the respondents are female. 85% adopted the nuclear family system, and 50% of respondents are illiterates in the study areas. 85% of respondents are daily wage earners, 37%are earnings rupees between 2000-2500 per month. 27% of respondents are landless labours, and 37% of households possess below 2 acres of land. 40% of respondents suffer from health problems, and 44% consume rice as their staple food. 62% of respondents have debts, and 33% got from money lenders. 62% of respondents do not have toilet facilities and go open defecation. 92% of respondents stated that toilet makes dignity, saves time and energy, saves their children school days, makes adolescent girls privacy, save wage loss, and toilet makes quality life.

B suresh lal

Tobacco smoking negatively affects the quality of saliva and affects many biological parameters including salivary α-amylase enzyme activity. Salivary α-amylase enzyme is essential for the catabolism of carbohydrates. Forty- five healthy male volunteers aged between 18 and 69 years (40.0 ± 15.0) were divided into two groups, namely, the control group (n = 21) and the cigarette smoker group (n = 24). The effect of smoking on salivary α-amylase enzyme activity depends on the number of smoked cigarettes per day and the type of cigarettes as well as the period for how long the person smoking tobacco cigarettes was investigated. Different methods were used to analyze the activity of salivary α-amylase enzyme including the dinitrosalicylic acid method (standard colorimetric method). The results showed a significant increase (P < 0.05) in salivary α-amylase activity in Libyan smokers compared to the non-smokers in the morning and night, also, the findings showed a significant decline in salivary α-amylase activity during the increasing smoking period. The activity of salivary α-amylase in the young age smokers group increases in morning and night compared to the non-smokers group. There is no change in the activity of salivary α-amylase in the middle and older adult groups in the morning and night compared to young smokers group. In conclusion, smoking for a long period time more than 20 cigarettes per day decreases the activity of salivary α-amylase in Libyan subjects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Ageing is an inevitable phenomenon. Similar to other organs, skin is also subject to an intrinsic ageing process. Additionally, skin ageing is also influenced by various environmental factors. Existing conventional formulations have limited efficacy because skin serves as a rate limiting barrier for percutaneous absorption of drugs. This has led to the evolution of various novel drug delivery systems. Among these liposomes have received considerable attention due to the numerous advantages they offer. Liposomes, submicroscopic spherical vesicles, were discovered in 1960’s. Since then, they have gained popularity as potential carriers for drugs, diagnostics, nutrients, vaccines and other bioactive agents. Liposomes find applications in pharmaceutical, cosmetics and other industrial fields. Various topical actives that have been found to be efficacious in delaying the signs of ageing have been formulated as liposomes resulting in enhanced delivery, biocompatibility, and reduced toxicity. This review focusses on therapeutic use of liposomes in skin ageing.

Aparajita varshney

Management accounting refers to the process of collecting, organising, and recording financial transactions with the aim of providing information for the management to make informed decisions about the operation of an organisation (Ameen, Ahmed, and Abd Hafez, 2018). Management accounting allows organisations to conform to the expectations of various financial agencies, such as tax agencies, by ensuring that all transactions that take place within an organisation are done correctly (Järvinen, 2016), thus enabling the organisation to meet its goals and objectives.

Zamzam abdelazim

The study identified the pragmatic competence level of the second language (L2) learners through Written Discourse Completion Test (WDCT) administered to purposively selected 40 first-year education students. A modified questionnaire based on Survey for Academic English Language Exposure (SAELE) was used to determine the effectiveness of academic English language exposure on the pragmatic competence development of the respondents. The study employed the descriptive-correlational method, while various statistical tools were utilized to analyze and interpret the data. Weighted mean was used to determine the respondents’ pragmatic competence level and the effectiveness of academic English language exposure on the pragmatic competence development of the respondents. Moreover, Pearson Product Moment Correlation (PPMC) was employed to determine the significant relationship between the two variables. Results in WDCT showed that the average scores in the pre-test and post-test results fall under the competent level. Meanwhile, the effectiveness of academic English language exposure on the pragmatic competence development of the respondents was 0.207, which is ineffective. Lastly, the statistical correlation of the two variables showed no significant relationship between them (r=0.046, p>0.05). Based on the study’s results, pedagogical implications for pragmatic and L2 teaching and learning were conceptualized.

Darrel ocampo

This mathematical model forms machine cells, optimises the costs of unassigned machines and components, and designs the shop floor cell layout to have minimal movement of materials. The complete similarity measure algorithm forms machine cells and part families in a refined form. Later, exceptional elements are eliminated in the optimisation model by using machine duplication and sub-contracting of parts. Then the shop floor layout is designed to have optimised material movements between and within cells. An evaluation of the cell formation algorithm’ performance is done on the benchmark problems of various batch sizes to reveal the process’s capability compared with other similar methods. The data of machining times are acquired and tabulated in a part incidence matrix, which is used as input for the algorithm. The results from the linear programming optimisation model are that costs are saved, machines are duplicated, parts are sub-contracted, and there are inter- and intra-cellular movements. Finally, the output of the inbound facility design is the floor layout, which has machine cell clusters within the optimised floor area.

S ramesh

Background: Poverty and malnutrition are associated with the risk of developing tuberculosis (TB). Nutritional reintegration with anti-TB therapy may improve treatment success rate. Aim: To investigate the nutritional status of low-income pulmonary TB patients in relation to the different anti-TB treatment phases. Methods: Forty five pulmonary TB patients and 40 controls aged 19-54 years, receiving treatment at Infectious Disease Hospital, Calabar, Nigeria, between September 2018 and July 2019 were studied. Serum total protein, albumin, iron and vitamin A were determined by colorimetric and HPLC methods respectively. Height and weight were measured and BMI computed, and data analysed using Student’s t-test, ANOVA, and Pearson’s correlation at P<0 P=0.001).>0.05) respectively. Albumin and iron were significantly lower in CPAT-HIV compared with CPAT patients. Albumin correlated positively and significantly with iron (r=0.405, p=0.006) in TB patients. Conclusion: Tuberculosis is associated with decreased BMI, albumin, iron and vitamin A, and higher total protein, and globulin, suggesting that malnutrition may be associated with TB risk, poor treatment compliance and outcomes

Eworo raymond

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

La lecture de toute production romanesque signée d’une Africaine, laisse souvent transparaître a priori l’idée qu’elle évoque la victimisation de la femme par la gent masculine. Mais, à certain niveau, l’univers de sa fiction n’affiche pas de façon catégorique ou formelle cette question. Tel est le cas de Fatou Diome avec son roman en cours de décryptage. Le but de cet article est de montrer que l’auteure construit son texte autour de plusieurs facettes pour assurer la transmission des valeurs identitaires et que le choix de certains genres oraux et l’évocation de la problématique de genre (homme-femme) offrent des concepts qui servent à exprimer des faits propres à l’identité culturelle africaine. À partir d’une analyse thématique et sociocritique, nous comprenons qu’elle adosse insidieusement à ce thème la problématique de l’identité. Ce, à partir de plusieurs artifices littéraires qui sont entre autres le potentiel oral traditionnel du terroir et le discours revalorisant la femme, par ricochet l’identité africaine.

Assanvo

Now-a-days there is a renewed interest in drugs of natural origin simply because they are considered as green medicine and are always safe. The advantage of natural drugs is their easy availability, economic and less or no side effects they have been used in traditional medicine practices. In the present investigation some medicinal weeds were analyzed, it includes Centella asiatica, Phyllanthus niruri, Argemone mexicana, Amaranthus viridis, Asclepias currasavica, Cyperus iria and Portulaca oleraceae. All the eight medicinal weeds collected during field visits were subjected to study organoleptic features, macroscopic studies, powder analysis, physicochemical limits and fluorescence analysis, single and double staining techniques.

Veerabhadraswamy al

This research is the result of research that describes the implementation of the Take and Give learning model in the fifth grade social studies subject at MI Ar-Rahim, Arjasa, Jember. The learning process includes 3 stages, namely the planning, implementation, and evaluation stages. This research aims to answer. Based on the background described above, the formulation of the problems in this study are: 1. How is the preparation in implementing the Take and learning model for class V social studies subjects at MI Ar-Rahim, Arjasa District, Jember Regency? 2. What is the process of implementing the Take and Give learning model for the fifth grade social studies subject at MI Ar-Rahim, Arjasa District, Jember Regency? 3. How is the evaluation in implementing the Take and Give learning model for the fifth grade social studies subject at MI Ar-Rahim, Arjasa District, Jember Regency? The research method used is descriptive qualitative with data collection techniques using observation, interviews and documentation. The data sources in this study were the Principal, Teachers and Grade V Students of Class V Social Studies at MI Ar-Rahim, and other supporting documents. The results of this study indicate: 1. The implementation of the Take and Give learning model in the preparation stage has fulfilled all preparations well. 2. The process of implementing learning in class makes the learning atmosphere fun and students become more active. 3. At the evaluation stage all students have reached the assessment criteria in 3 aspects of the assessment, namely attitudes, knowledge and skills Penelitian ini adalah hasil penelitian yang menggambarkan tentang implementasi model pembelajaran Take and Give pada mata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember. Proses pembelajaran tersebut meliputi 3 tahap, yaitu tahap perencanaan, pelaksanaan, dan evaluasi. Adapun penelitian ini bertujuan untuk menjawab Berdasarkan latar belakang yang telah dipaparkan di atas, maka rumusan masalah dalam penelitian ini adalah: 1. Bagaimana persiapan dalam mengimplementasikan model pembelajaran Take and mata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember? 2. Bagaimana proses dalam implementasi model pembelajaran Take and Givemata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember? 3. Bagaimana evaluasi dalam mengimplementasikan model pembelajaran Take and Givemata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember? Metode penelitian yang digunakan adalah kualitatif deskriptif dengan teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Adapun sumber data dalam penelitian ini adalah Kepala Sekolah, Guru dan Peserta didik kelas V mata pelajaran IPS kelas V di MI Ar-Rahim, dan dokumen penunjang lainnya. Hasil penelitian inimenunjukkan: 1. Implementasi model pembelajaran Take and Give pada tahap persiapan sudah memenuhi segala persiapan dengan baik. 2. Proses pelaksanaan pembelajaran dikelas membuat suasana belajar menjadi menyenangkan dan peserta didik menjadi lebih aktif. 3. Pada tahap evaluasi semua peserta didik telah mencapai kriteria penilaian dalam 3 aspek penilaian yaitu sikap, pengetahuan dan keterampilan.

Educare: journal of primary education

This research was conducted to form students to be more disciplined in maintaining time, especially in prayer, as well as to strengthen aqidah and increase the worship of students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah. The focus of this research is: 1) How to plan the prayer chapter of fiqh learning through audio-visual media for students of Class IV Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung, 2) How to implement the prayer chapter of fiqh learning through audio-visual methods for students of Class IV Madrasa Ibtidaiyah Salafiyah Syafi 'iyah Ajung, 3) How is the evaluation of fiqh learning in the prayer chapter for fourth grade students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung. This research uses qualitative research with descriptive qualitative research. Determination of research subjects in this study was carried out purposively. Data collection techniques used observation, interviews, and documentation. Analysis of the data, the researcher used the data analysis model of the Miles, Huberman, and Saldana models including: Data Condensation (Condensation), Data Presentation (Display), Conclusions Drawing. The validity of the data in this study used source triangulation and technical triangulation. The results showed that: 1) The use of audiovisual media was very relevant in learning fiqh in the prayer chapter 2) Active, innovative, creative, effective and fun learning made students enthusiastic and enthusiastic in learning and not boring. 3) the completeness of learning facilities and infrastructure is very influential in the evaluation stage including summative evaluation and formative evaluation, input evaluation, process evaluation and output evaluation. Penelitian ini dilakukan untuk membentuk peserta didik lebih disiplin dalam menjaga waktu khususnya dalam shalat, serta memantapkan aqidah dan meningkatkan ibadah peserta didik Madrasah Ibtidaiyah Salafiyah Syafi’iyah. Fokus penelitianini adalah: 1) Bagaimana Perencanaan Pembelajaran fiqih bab sholat melalui media audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 2) Bagaimana Pelaksanaan pembelajaran fiqih bab sholat melalui metode audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 3) Bagaimana evaluasi pembelajaran fiqih bab sholat bagi peserta didik kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung. Penelitian ini menggunakan penelitian kualitatif dengan jenis penelitian kualitatif deskriptif. Penentuan subyek penelitian dalam penelitian ini dilakukan secara purposive.Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data, peneliti menggunakan model analisis data model Miles, Huberman, dan Saldana meliputi: Kondensasi Data (Condensation), Penyajian Data (Display), Penarikan Kesimpulan (Conclusions Drawing). Keabsahan data dalam penelitian ini menggunakan triangulasi sumber dan triangulasi teknik.Hasil penelitian menunjukkan, bahwa: 1) Penggunaan media audiovisual sangat relevan dalam pembelajaran fiqih bab sholat 2) Pembelajaran aktif, inovatif, kreatif, efektif, dan menyenangkan membuat peserta didik semangat dan antusias dalam belajar serta tidak membosankan. 3) kelengkapan sarana dan prasarana pembelajaran sangat berpengaruh pada tahap evaluasi meliputi evaluasi Sumatif dan evaluasi Formatif evaluasi input, evaluasi proses dan evaluasi output.

Educare: journal of primary education

In the United States, prisoner reentry programs are a necessity to re-integrate back into society and are of two types: Faith and Non-Faith. With increased emphasis placed on reforming the criminal justice system policies due to Black Lives Matter and other non-profits actively working to change the system from the outside, reentry programs are having a resurgence of interest for effective public policy. There are significant barriers for major policies at the state, local, and federal to be alleviated, nevertheless, our research wanted to consider the effectiveness of five faith-based, male-only reentry programs in central Florida. Small focus groups were utilized to better understand the concerns and issues returning inmates faced in the program as well as when returning to society. Reentry participants were found to have high confidence in the success of their participation in their faith-based program’s efforts on their personal and family growth.

International journal of business and social science research

Digital governance has become a cornerstone of modern administrative systems, enabling governments to provide efficient and transparent services to citizens. Telangana, a state in southern India, has emerged as a pioneer in implementing various digital governance initiatives to enhance service delivery and promote inclusive development. This paper provides a comprehensive overview of the digital governance initiatives undertaken by the Government of Telangana, highlighting their objectives, key features, and impact on governance. The paper begins by outlining the context of digital governance in Telangana, emphasizing the state government's commitment to leveraging technology for governance reforms. It then delves into specific initiatives across various sectors, including e-governance, digital infrastructure, citizen services, and smart city projects. Each initiative is analyzed in terms of its objectives, implementation strategies, technological components, and outcomes. Key initiatives such as the Telangana State Portal, T App Folio mobile app, MeeSeva portal for e-services, and the T-Fiber project for broadband connectivity are discussed in detail. Additionally, the paper examines the integration of emerging technologies like artificial intelligence, blockchain, and Internet of Things (IoT) in governance processes to improve efficiency and transparency. Furthermore, the paper evaluates the impact of these initiatives on governance outcomes, including enhanced service delivery, increased transparency, and improved citizen engagement. It also identifies challenges faced in the implementation process and offers recommendations for overcoming them. Overall, this paper provides valuable insights into the digital governance landscape in Telangana, showcasing the state's efforts in harnessing technology to build a more efficient, responsive, and citizen-centric administration. By documenting the successes, challenges, and lessons learned, it aims to inform policymakers, researchers, and practitioners interested in digital governance and public administration reform.

Dr gedam kamalakar

The 2019 coronavirus disease (COVID-19) was declared by the World Health Organization as a pandemic on 11th March, 2020 which spread rapidly all over the world. COVID-19 disease has different clinical presentations, ranging from asymptomatic to severe symptoms. Laboratory findings are important in determining which therapeutic strategies to seek and to identify severe cases initially. In this study, we compared the results of C-reactive protein, D-dimer, blood electrolytes and mean corpuscular hemoglobin concentration between survivors and non-survivors of 22 Libyan patients with COVID-19 present in the intensive care unit at Maitika Isolation Center (Tripoli, Libya) in the period of January to June 2021. We could not detect any significant difference in C-reactive protein between survivors and non-survivors but a significant difference in D-dimer level was observed. Non-survivor COVID-19 patients have a higher level of D-dimer. Moreover, a statistical significant difference in chloride and sodium levels but not in potassium level were detected. A marked lower of mean corpuscular hemoglobin in non-survivor than survivor COVID-19 patients was shown. Thus, these parameters could act as biomarkers for COVID-19 patients.

Mediterranean journal of pharmacy and pharmaceutical sciences

Personnel Department is the predominant component of HRD unit of North Eastern Karnataka Road Transport Corporation (NEKRTC), though HRD has been identified and designated as a separate Department. Basically the existing Personnel Department is qualified to be called HR Department OR even a better name would be Human Resources Management Department, since it would correctly reflect the comprehensive and all inclusive nature of the functions of the existing Personnel Department, which covers all features of Human Resources Management, namely Forecast of requirement of Human Resources, Planning for Recruitment, In-service care Co-ordination, Control and Regulation as also Retirement and all matters related to Personnel Administration. It should be its function to plan for training appropriately along with recruitment of personnel from all the Departments. The present Human Resource Development. Is ill-equipped and does not have the comprehension of concept and perception of HRD.

Dr.kailaspathi vishwakarma

Higher Education has an important role in the task of rebuilding a nation and it pavCes the way for overall development of a nation. The twentieth century has witnessed several revolutions like Green revolution, White revolution, I.T revolution, so on and so forth, taking human civilization to new heights. At the start of 21st century, we gave a lot of importance given to higher education. Every country realized the value of higher education and the benefits that accrue from it. “The social demands for higher education continue to increase. The inabilities of the state to support this growing demand result in new financing arrangements for higher education. The recent reforms in this area could be broadly divided into two categories: the privatization of public institutions and the establishment of private institutions of higher education. Privatization implies the application of market principles in the operation of public institutions, while ownership rests within the public domain. Promotion of the private sector implies the growth and expansion of the non-state sector in higher education, and very often this sector does not rely on state funding for its growth and expansion. Both of these measures have paved the way for market operations in higher education

Dr gedam kamalakar