Wilsons disease is a rare inherited disorder which is characterized by impaired copper excretion which leads to excessive deposition of copper in many tissues and organs like brain, liver, and eye. This is also characterized by Kaiser-Fleischer ring, low serum ceruloplasmin levels and elevated urinary copper excretion [1]. A 26year male patient came to the neurology department with chief complaints of involuntary tremors of both hands and difficulty in walking in the last one month associated with swaying to one side in the last 20 days. On examination the patient is having Kaiser-Fleisher ring positive and upon further investigation Magnetic resonance imaging brain was performed which revealed the features in favor of Wilson’s disease. And for this condition the patient is treated with chelating agents and benzodiazepines.

Dr venkata rama rao nallani

Saline and sodic (alkali) soils can significantly reduce the value and productivity of affected land. By estimation, slightly more than one-fourth of irrigated farmland in the United States is affected by soil salinity. Ions most commonly associated with soil salinity include the anions chloride (Cl–), sulfate (SO4=), carbonate (HCO3–), and sometimes nitrate (NO3–) and the cations sodium (Na+), calcium (Ca++), magnesium (Mg++), and sometimes potassium (K+). Crops differ in ability to tolerate salt accumulation in soils, but if levels are high enough (more than 16 mS/cm), only tolerant plants will survive. As salts accumulate in soil, the soil solution osmotic pressure increases. Reclamation of sodic soils is different; excess sodium must first be replaced by another cation and then leached. Sodic soils are treated by replacing the sodium with calcium from a soluble source.

Svedbergopen

Background: Dilation of pupil in Ophthalmic OPD is a routine procedure. Whether a sympathomimetic agent like phenylephrine should be used in hypertensive patients is still a question to be answered. This study tries to resolve the issue. Objective: To evaluate cardiovascular effects of combination of topical 5% phenylephrine and 0.8% Tropicamide. Method: Total 150 patients were subjected for this study (male and female) between 30-80 years of age. Combination of 5% phenylephrine and 0.8% tropicamide eye drops was instilled at an interval of 15 minutes thrice in the eyes of each patient. Any change in BP or HR was recorded Result: The data was collected and subjected to appropriate statistical method using R software version 4.2.1. This study has shown no significant increase in Blood Pressure and Heart Rate after instillation of 5% Phenylephrine and 0.8% Tropicamide eye drops except in one case. Conclusion: We conclude that combination of 5% Phenylephrine and 0.8% Tropicamide can be safely used in all patients who come for ocular examination but precautionary measures should be taken in hypertensive patients.

Dr. ashwani kumar ghai

The study employed Appreciative Inquiry framework to have an in-depth investigation in the personal lives of the participants and to draw connections between their beliefs and practices in taking Licensure Examination for Teachers and how these superstitions reflect and affect their moral principles. Specifically, it aimed to: (1) determine the superstitious beliefs followed by the examinees before, during, and after taking the Licensure Examination for Teachers (LET); (2) determine the positive and negative impact of these superstitions in the aspect of taking LET; and, (3) identify the effects of these superstitions in the characters and principles of the teachers. Semi-structured interview and focus group discussion were used and the data-sources were triangulated to come-up with a stronger analysis. Audit trail and member checking were followed to ensure that there were no biases in the interpretation of the data and to establish the validity of the results. Findings revealed that the student examinees followed different superstitious beliefs before, during and after the exam which have positive and negative effects. The motive of avoiding failure in the examination predominates over the motive of achieving success. The positive and negative effects of superstitions vary from one person's experience to another. Moreover, the assertion and personal disposition to pass the exam became the product of student examinees' projection. The superstitious notions were initiated to discard the student examinees' fears and to safeguard their emotional sphere against negative feelings and any untoward possibilities. Meanwhile, in the development of moral principle, the student examinees' family, peers and the society are important factors in the establishment of their belief system which later on reflects the moral principles they uphold.

Darrel ocampo

A performance analysis on a vapour compression refrigeration system with various refrigerants mixture of R152a, RE170, R600a, and R290 were done for various mixture ratios and their results were compared with R134a as possible alternative replacement. The results showed that all of the alternative refrigerants investigated in the analysis except R431A, [R 152a (29%), R290 (71%)] have a slightly higher performance coefficient (COP) than R134a for the condensation temperature of 500C and evaporating temperatures ranging between -300C and 100C.Refrigerant blend of R152a/RE170 (20/80 by wt%) instead of R134a was found to be a replacement refrigerant among other alternatives. The effects of the main parameters of performance analysis such as refrigerant type, degree of sub cooling and super heating on the refrigerating effect, coefficient of performance and volumetric refrigeration capacity were also investigated for various evaporating temperatures.

Baskaran

Woman constitutes the family, which leads to the development of society and Nation. The social and economic development of women is necessary for the overall economic advancement of any society or a country. Entrepreneurship comprises venture activities that are the center of the recognition of various opportunities, creativity, and innovation in the production process and development of new business models and ventures. Entrepreneurship plays a major role in developing society of a fastdeveloping country like India. In comparison to other countries, the event of women entrepreneurship is extremely low in India, especially in rural areas. However, middle-class women aren't too eager to alter their roles because of fear of social backlash. The growth is more visible among high families in urban areas. Rural women frequently have primary responsibility for agricultural production, additionally to domestic responsibilities and childcare. In developing countries like India where the economic status of women is extremely pathetic especially in rural areas and opportunities of earning are very less. For establishing self-esteem and recognition in society, women are attracted to entrepreneurship. To sustain within the competitive market, businesses administered by women are mainly hooked into internal resources and their capabilities supported which they struggle to compete with the external environment. The present paper endeavors to study the opportunities and challenges of women entrepreneurs. The study aims to analyze the factors that encourage women entrepreneurs. This study is based on secondary data collected from previous research papers, journals given by various research scholars, blogs, and websites. This study concludes that women entrepreneurs should be provided with special training facilities to overcome challenges and for developing their skills and talents.

Mamta gaur

The human body has been theorized in many ways, including the entire notion of the woman as a human creation. It is generally agreed that this concept refers to our perceptions, thoughts, and feelings about our bodies, which influence our behaviour about our bodies. The article examines numerous authors whose individual genealogies meet on the common ground of identity theory and women's lives and is supported by a theoretical framework based on conceptions of identity, body-image and self-image in women and feminist discourse. This paper probes into the concepts of identity in women through the literary canvas of Dr. Bhabendra Nath Saikia and demonstrates the effects of body image and self-image on the development of identity. Of course, an extensive discussion of the short stories of Dr. Saikia is beyond the scope of this paper. The aim of this paper is to analyse the concepts through the two short stories short titled "Dhura Xaap" (ঢ োৰো সোপ 1958) and "Sringkhol" (শ ৃংখল, 1970) by Dr, Bhabendra Nath Saikia. The paper seeks to explore the concepts of self-image, identity and body image through three female characters ‘Chandrika’, ‘Janeki’ and ‘Ambika’.

Banani das

This mathematical model forms machine cells, optimises the costs of unassigned machines and components, and designs the shop floor cell layout to have minimal movement of materials. The complete similarity measure algorithm forms machine cells and part families in a refined form. Later, exceptional elements are eliminated in the optimisation model by using machine duplication and sub-contracting of parts. Then the shop floor layout is designed to have optimised material movements between and within cells. An evaluation of the cell formation algorithm’ performance is done on the benchmark problems of various batch sizes to reveal the process’s capability compared with other similar methods. The data of machining times are acquired and tabulated in a part incidence matrix, which is used as input for the algorithm. The results from the linear programming optimisation model are that costs are saved, machines are duplicated, parts are sub-contracted, and there are inter- and intra-cellular movements. Finally, the output of the inbound facility design is the floor layout, which has machine cell clusters within the optimised floor area.

S ramesh

Financial sector needs special attention pertaining to incorporation of the ESG criteria. Economic and financial issues coupled with climate change would have negative impact on the stability of financial institutions. This research paper attempts to synthesize and summarise scholarly articles published in Scopus database on ESG domain with reference to banking sector using bibliometric analysis. The objective of this review paper is to understand from past literature the trajectory of studies in the domain of ESG. There is a substantial growth in frequency of publication in the year 2022 along with annual growth of around 30 percent during 2015-2023. Bibliometric with MS-Excel, R-Studio and VOS-viewer were used to identify and analyze research trends related to the number of studies, research fields, authors, nations, institutions, and keywords. The important keywords identified in the bibliometric analysis were sustainability, corporate social responsibility, sustainable finance, banks performance.

Dr. mohammed nizamuddin

Several diseases affect maize plants and one among them is black bundle disease, causal organism of which is yet to be confirmed with conflicting reports appearing in literature. In the present work, an effort was made to record the disease incidence by carry out filed surveys in Southern most district of Karnataka state, India and also to isolate and identify the causal organism. The surface sterilized pith tissue from the infected plants was cultured on PDA medium to identify the organism in the affected vascular tissue. The isolated tissue produce Cephalosporium acremonium which was confirmed based on morphological characters. In addition, Simplicillium sp. and Macrophomina phaseolina were also isolated from the same infected plant material and suspected to have participated in the disease development. In accordance with several reports in literature, Cephalosporium acremonium was tested and confirmed as the causal organism of disease in green house experiments by following the Koch’s postulates. This is in contrast with some earlier reports, wherein the exact symptoms of black bundle disease were reported as barren stalks in corn caused by Fusarium sp. The simplicillium sp. which had morphological similarity with C. acremonium and had an ambiguous taxonomic status in literature was confirmed as a distinct species through PCR based diagnosis.

Veerabhadraswamy al

Introduction: During the COVID-19 pandemic, most educational institutions have opted for online education rather than traditional modes of education to protect their employees and students. Online education has been gaining momentum in almost all countries around the world. This coincides with the recently introduced competency-based medical education in India which has embraced online education. This poses a new challenge for the institutions involved, the instructors or teachers, and the students since they must adapt quickly to the new mode of learning. Online education requires teachers to improve their competency in three major areas; pedagogy, technology, and content knowledge. Some of the challenges include; lack of technological skill, poor time management and lack of infrastructure. As technology rapidly advances, health care education systems must also advance in tandem. To implement the new competency-based system and online education, the institutions and the individuals must realize the importance of online education, identify the barriers and quickly work on solutions for success. Methods: This review was conducted based on various research papers on the topic of online medical education, the challenges faced by faculty members, and the opinion of students on this dilemma. Search terms included online medical education, COVID19, competency-based medical education. Conclusion: This review identified various challenges posed by online education on the current medical curriculum, faced by both faculty members and students, especially under the light of the Competency-Based Undergraduate Curriculum for Indian Graduates. Different solutions were proposed to overcome these challenges.

Nirav

This study examined the level of physical access of pupils to lower basic schools in Rivers State. One research question guided the study. The descriptive research design was used. The population for the study was the 942 public lower basic schools in Rivers State. A sample of 289 schools was used for the study. Stratified random sampling was used to draw the sample. Document analysis was the instrument used for the study. The instrument was validated by five experts. Mean statistics was used to answer the research question. Findings revealed that the radius per child for pupils in Rivers State lower basic schools is unsatisfactory high. It was therefore recommended among others that the Ministry of Education in collaboration with the Universal Basic Education should ensure that schools are properly sited in such a way that it will adhere to the 2-kilometre standard distance for developing countries. The Ministry of Education should ensure strict compliance with the policy provision on the maximum distance a child could cover to access the nearest school by re-mapping the current school network.

Fxintegrity publishing

Rasa aushadhis are known for their uniqueness in curing the diseases with a very low dosage. These formulations are divided into two types based on their mode of preparation i.e., Single drug and Compound drug formulations. Based on their origin, the drugs are divided into three types, Herbal, Mineral and Animal. Any of these two or three together is combined to make a compound formulation. Apart from these, the other major factor which is needed for a formulation is the Rasa Panchaka of a Drug. Many of the formulations are being prepared based on their availability, keeping their Rasa Panchaka and Samprapti vighatana in mind. These formulations are designed in such a way that two or more drugs will be having one common quality, or Opposite Qualities or an Antidote of a particular Vishadravya, which can help in curing the disease. So an attempt is made to Review Tribhuvanakeerti Rasa with its Probable mode of action.

Suri abhiram

Cloud computing is used to achieve sustainability in terms of computing. It reduces energy and resource consumption. Most of the companies have been moving their applications to the cloud to reduce power, energy re-source, and carbon emission. Today's computing landscape is rapidly shifting toward creating applications to leverage Cloud platforms to have necessary features such as elasticity, virtualization, low cost, and pay-per-use. Cloud computing's rising demand and versatility are achieving acceptance in the research community as a means of implementing large-scale electronic systems in the format of workflows (set of tasks). One of the most important objectives of this effort is to trim down makespan which is the total period taken by the resources to complete all workflow activities. Another foremost objective of this work is to satiate all the user-delineated time constraints while scheduling workflow activities.

Mohd haroon

Introduction: Traumatic brain injury is caused by an external physical force which may result in altered level of consciousness with or without impairment of cognitive and physical functions in individuals. It is neither congenital nor degenerative in nature. The impairments can be permanent with partial or total functional disabilities or psychosocial maladjustment. The Intensive rehabilitation with multiple health disciplinary teams can improve a certain extent of physical and cognitive aspects of brain injury patients. Case Report: In this case report we are presenting a 19 year old boy diagnosed as diffuse axonal injury with Glasgow coma scale (GCS ) Score of 4/15 (E1M2V1) at the time of incident has come to our department after 8 months with no head control, no cognitive and no voluntary attempts to do functional activity. The main objective of management is to improve mobility, communication, perception and cognitive functions with minimum period of time by working as a health team. Conclusion: After 14 months post incident with intense rehabilitation of six months his GCS score is improved with scoring of 13/15 (E4M6V3). The improvement seen may be partly attributed to the coordinated work of the team members who meet in the case conference every two weeks to review & revise the treatment protocol. Such that common and individual goals are shared and total therapy time is managed, to incorporate all goals by team members

Nagarjuna narayanasetti

NIRS is an advanced, fast, reliable, and non-destructive technique that is extensively used in the chemical, food, petrochemical, and pharmaceutical industries for rapid and reliable standardization. NIRS of Cicer arietinum L. Desi and Kabuli variety seed flours were performed to evaluate secondary metabolites qualitatively. The principal suggested compounds in Cicer arietinum Desi and Kabuli variety were found as adenine, biochanin-A, biochanin-B, biochanin A 7-O- β -D-glucoside, calycosin, cerebroside, choline, ciceritol, citric acid, daidzein, fructose, garbanzol, genistein, glucose, inositol, isoliquiritigen, liquiritigenin, methyl tetracosanoate, ononin, pyrimidine, saccharose, sissotrin, stigmasterol, trifolirhizin. β- amyrin and β-sitosterol. These compounds' presence justifies using Cicer arietinum as a nutritional food and tonic.

Dr. salman ahmed

X-ray crystallography has been central to the development of many fields of science over the past century. It has now matured to a point that as long as good-quality crystals are available, their atomic structure can be routinely determined in three dimensions. However, many samples in physics, chemistry, materials science, nanoscience, geology, and biology are noncrystalline, and thus their three-dimensional structures are not accessible by traditional x-ray crystallography. Overcoming this hurdle has required the development of new coherent imaging methods to harness new coherent x-ray light sources. Here we review the revolutionary advances that are transforming x-ray sources and imaging in the 21st century.

Nima fahimian, md

This case is designed to highlight the marketing strategies adopted by a new entrant in the fast-moving consumer goods (FMCG) sector. The importance of brand architecture in building brand relevance in this competitive environment and enhancing customer loyalty has been put forth as illustrated by the experts. The synchronization of branding strategies and marketing communications in terms of establishing a customer connect purely on the basis of nationalism, price, and natural preparations have been highlighted from the perspective of Patanjali’s growth strategy. The brand has been envied by all the big players of the sector for proving itself as the major disruptor being portrayed in terms of its voluminous sales and ever-rising revenues. This case on Patanjali offers an insight into the strategies followed by a new company to position the brand at the right time and acquire a substantial market share. It also highlights the facts that exceptional competitiveness in distribution strategies may not be the only determinant for effective management of distribution strategies, and the road ahead needs to be rightly sorted out. This case also tries to unlock the path that determines the success the brand Patanjali has achieved which otherwise took decades for Nestle, Proctor & Gamble, ITC, or Unilever to achieve.

Dr. neena prasad

Malignant melanoma is the most dangerous type of skin cancer. It is becoming more common globally and is increasingly resistant to treatment options. Despite extensive research into its pathophysiology, there are still no proven cures for metastatic melanoma. Unfortunately, current treatments are frequently ineffective, costly, and have several adverse effects. Natural substances have been extensively researched for their anti-MM capabilities. Chemoprevention and adjuvant therapy with natural products is an emerging strategy to prevent, cure or treat melanoma. Numerous prospective drugs are found in aquatic species, providing a plentiful supply of lead cytotoxic chemicals for cancer treatment. Anticancer peptides are less harmful to healthy cells and cure cancer through several methods, such as altered cell viability, apoptosis, angiogenesis/metastasis suppression, microtubule balance disturbances and targeting lipid composition of the cancer cell membrane. This review addresses marine peptides as effective and safe treatments for MM and details their molecular mechanisms of action.

Dr. salman ahmed

Fused silica capillaries treated with N, N-didodecyl-N, N-dimethylammonium bromide was used in capillary electrophoresis to separate basic proteins using ammonium acetate as BGE at pH 4.0, 70 mM. This surfactant forms a semi-stable coating that provides a strong anodic electroosmosis; however, such coating must regularly be regenerated to maintain efficiency and reproducibility. The temporal stability of the coating was greatly improved by a new procedure as described in previously study by our group. In this study, it is found such experimental conditions that the starting zone could be enriched without loss of sample. The injection of a short plug of the BGE diluted 100 times for 3 sec in 50 µm i.d. capillaries behind the sample zone at 15 kV gave the best performance, whereas, a plug of lower dilution degree (10 times) in 25 µm i.d injected for 3 sec at the same field strength gave the optimum results for this dimension. In conclusion, those conditions were found to effectively decrease the loss of sample and to give a higher separation performance in regard to peak efficiency and resolution compared to injecting the sample without a plug.

Mediterranean journal of pharmacy and pharmaceutical sciences