Urolithiasis, the process of urinary stone formation, entails the presence of compact masses like whewellite, brushite, and urate within the urinary system. Gout, characterized by inflammatory arthritis, emerges from the accumulation of urate (MSUM) crystals. In vitro, examinations focusing on the growth of whewellite (COM), brushite (CHPD), and urate (MSUM) crystals on glass slides present a cost-effective approach for gaining valuable insights into urolithiasis and gout. These studies not only delve into crystal growth patterns but also investigate the potential inhibition of crystal growth through the application of plant infusions, thereby laying the foundation for further extensive research in these domains.

Dr. salman ahmed

Urolithiasis is a common worldwide problem with high recurrence. This review covers thirteen (13) antiurolithiatic plants of the family Boraginaceae, twenty (20) from Brassicaceae, twenty-three (23) from Malvaceae and twenty-four (24) from Poaceae used globally in different countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Concrete is a material which is used in construction. Weight of concrete plays a major role in the construction industry. If the weight of the concrete is increased, it will pose more structural problems on the later date of construction. It also increases the cost of construction, without any specific benefit. So if lightweight concrete is used, it not only reduces cost of construction, but also not poses any structural problems unnecessarily. Light weight concrete also aids workers in smooth handling of materials. In this study, vermiculite in the form of exfoliated form is used to replace partially natural sand. By this action dead weight of the structure is reduced. Once the dead weight of structure is reduced, it in turn reduces cost of construction. In this study three mixes were casted with the cement content of 383 kg/m3 in M20 concrete and the water cement ratio of 0.45 is chosen. Vermiculite at 10%, 20% and 30% are choosing to partially replace the natural sand. The Tests conducted on concrete for evaluating mechanical properties include compressive strength and split tensile strength. For evaluating durability properties, tests like acid resistance, sulphate resistance, chlorine penetration and water absorption.

Kiran kumar narasimhan

Newcastle Disease Virus (NDV) constitutes a major constraint to the poultry production system in Nigeria. This study was carried out to investigate the seroprevalence of NDV antibodies in local chickens (Gallus domesticus) slaughtered in five different live bird markets (LBMs) in Kaduna metropolis, Nigeria. Three hundred blood samples were collected and screened for antibodies against NDV using Haemagglutination Inhibition (HI). An overall seroprevalence rate of 23% (95%:CI18.5-28.0) was recorded in this study. Seroprevalence based on different LBMs revealed a higher prevalence of 28.3% (95% : Cl 18.0-40.7) in Sabo market, followed by Sokoto road market 26.7% (Cl:16.7-38.9), Kawo market 18.3% (95% Cl: 10.0-29.6), Railway market 13.3% (Cl:6.4-23.5), and the lowest prevalence was recorded in central market 11.7% (Cl:5.2-21.7). The difference in seroprevalence among the LBMs was not statistically significant (p > 0.05). Higher seroprevalence of NDV antibodies in female birds 30.5 % (Cl: 24.1-37.6) was recorded compared to male 13.9% (Cl: 8.3-21.4). The study indicated that NDV is endemic in the population. LBMs location had no significant influence on the seroprevalence of NDV in the study area. The difference in seroprevalence between sexes was statistically significant (p < 0.05). Therefore, this study demonstrated the need for a regular strategic vaccination programme against NDV in local chickens in Kaduna metropolis.

Bitrus inuwa

This paper explores the topic of supply chain management using case studies of companies from the automotive industry. Focus is given to the manner in which supply chain strategies in the automotive industry are designed and implemented, and how automotive companies configure their supply chains through collaboration, lean principles and agility. The paper also explores how advanced technologies, notably Big Data analytics and the Internet of Things, are utilised in the automotive industry to maintain a competitive advantage. Key findings made in the discussion are that success in supply chain management is greatly enhanced if firms seek to integrate the different components making up the supply chain. Additionally, the collaboration between entities fosters trust, which is a vital ingredient in the application of lean principles. The automotive industry shows that companies should pursue flexibility and efficiency, which are captured in the notions of agility and leanness, respectively. The paper identifies collaboration and advanced technologies as two critical sources of sustainable competitive advantages to organisations primarily in reference to supply chain management.

Mohamed sorogy

Development of Human Resources is being given due importance by all the organizations as it aims at developing all the employees of an organization in a planned manner to acquire, sharpen and apply their existing capabilities as well as their inner potentials. HRD is a total system in which its various mechanisms are embedded together to act as an integrated unit. No sub-system can work in isolation. The researches show that the working of each sub-system has its impact on other subsystems e.g. Performance appraisal is basis for assessing training needs, career planning etc. Training is useful tool for increasing individual efciency. It is also a part of employee welfare and is used for promotions. Implementing these HRD sub-systems helps in developing a climate in the organization where the people collaborate with each other; respect and trust others and work as a team. This, in turn, develops a highly positive and motivated workforce which enables the organization to achieve its goals. Human being is a creature composed of heredity and environment and creates values for their own. In the context, during the interactions with others, the values manifest spontaneously. Human beings are tempted by all kinds of emotions, impulses, instincts, prejudices, wishful thinking, hopes, fears, desires, and almost everything.

Dr.kailaspathi vishwakarma

Autophagy is a self-digesting mechanism responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy. In microautophagy cytoplasm material is sequestered through direct invagination to the lysosomal membrane. Whereas in CMA proteins flagged with pentapeptide motif (KFERQ) were selectively degraded through direct translocation into lysosome. Macroautophagy involves the formation of subcellular double-membrane-bound structures called autophagosomes that contain degradable contents of cytoplasm materials and deliver them into lysosomes for breakdown by lysosomal enzymes. The molecular mechanism of autophagy involves several conserved Atg (autophagy-related) proteins. Systems produce modified complexes Atg8-PE and Atg5-Atg12-Atg16 as autophagy regulators. Autophagy is activated in response to diverse stress and physiological conditions. For example, food deprivation, hyperthermia, and hypoxia are mediated by factors like insulin/IGF-1, m-TOR signaling, FOXO transcription factors, and chaperones. The perturbance in autophagy may lead to several types of cancers, myopathies, and neuromuscular disorders. Several autophagy inducers and inhibitors like 3-methyladenine (3-MA), bafilomycin A1, LY294002 (LY), and Velcade have been used to treat disease is an intense field of study.

Kamal singh

Digital governance has become a cornerstone of modern administrative systems, enabling governments to provide efficient and transparent services to citizens. Telangana, a state in southern India, has emerged as a pioneer in implementing various digital governance initiatives to enhance service delivery and promote inclusive development. This paper provides a comprehensive overview of the digital governance initiatives undertaken by the Government of Telangana, highlighting their objectives, key features, and impact on governance. The paper begins by outlining the context of digital governance in Telangana, emphasizing the state government's commitment to leveraging technology for governance reforms. It then delves into specific initiatives across various sectors, including e-governance, digital infrastructure, citizen services, and smart city projects. Each initiative is analyzed in terms of its objectives, implementation strategies, technological components, and outcomes. Key initiatives such as the Telangana State Portal, T App Folio mobile app, MeeSeva portal for e-services, and the T-Fiber project for broadband connectivity are discussed in detail. Additionally, the paper examines the integration of emerging technologies like artificial intelligence, blockchain, and Internet of Things (IoT) in governance processes to improve efficiency and transparency. Furthermore, the paper evaluates the impact of these initiatives on governance outcomes, including enhanced service delivery, increased transparency, and improved citizen engagement. It also identifies challenges faced in the implementation process and offers recommendations for overcoming them. Overall, this paper provides valuable insights into the digital governance landscape in Telangana, showcasing the state's efforts in harnessing technology to build a more efficient, responsive, and citizen-centric administration. By documenting the successes, challenges, and lessons learned, it aims to inform policymakers, researchers, and practitioners interested in digital governance and public administration reform.

Dr gedam kamalakar

Blister beetle, Mylabris pustulata (Thunb.) is a polyphagous pest attacking flowers of pigeonpea (Cajanus cajan), cotton (Gossypium sp), lady’s finger (Abelmoschus esculentus), mungbean (Vigna radiata), urdbean (Vigna mungo), ricebean (Vigna umbellata) etc. throughout the country. Because of its polyphagous feeding nature and hard protective adaptation against insecticides, long term management of this pest with a single molecule is difficult. Therefore, field cum laboratory experiments were carried out for three consecutive cropping seasons during kharif 2008-09, 2009-10 and 2010-11 to find out the persistence and efficacy of different insecticides. It was found that decamethrin 2.8EC was 3334 times toxic with lowest LC50 value (0.0000563) followed by monocrotophos 36SL as compared with endosulfan which was the least toxic with LC50 value (0.1877). Insecticides evaluated for their persistent toxicity during 2009-10 revealed that decamethrin and thiodicarb caused cent per cent mortality of adult blister beetle immediately after spray. At 8th days after spraying, decamethrin caused 60 per cent mortality. Insecticides evaluated for their efficacy during the year 2010-11 revealed that the plants were found free from adult blister beetle population in treatments involving decamethrin and cypermethrin even at ten days after spray. Among all the treatments, spraying of thiodicarb 75WP @ 625 g ha-1 provided the highest grain yield (18.87 q ha-1). Maximum cost-benefit ratio was observed in monocrotophos 36SL, cypermethrin 25EC and decamethrin 2.8EC

Dr. babu lal jat

Here is presented a short review on the medical potency of the most toxic plant of Europe. In many countries it isn't concerned any more as therapeutic agent in medicine due to frequent intoxications. However, in the homeopathy, preparations and patent medicines still contain aconitine and other alkaloids (abundant levels). There exists even a US Patent "ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF" (No. US 9,085,536 B2 by du Bois et al. 2015).

Stefan dahl

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

Mamta gaur

The rate of oxygen consumption was measured in mercury chloride treated freshwater fish, cyprinus carpio for 96h and compared to control group. The present investigation showed that average oxygen rate was decreased in all treated animal as compared to controlled group. Behavioural changes was also recorded in both concentration. The behavioural alterations observed like surfacing, erratic movement, increased mucous secretion, decreased opercular movement and loss of balance. The present study revealed that, mortality rate increased with increases in concentration.

.vijay digambar suryawanshi

Alternative Learning System (ALS) has been adopted in Philippine basic education, yet there is no academic institution in the region prepares ALS teachers in teaching life skills. ALS teachers graduated from different programs of teacher education for formal education. In response, an extension project was conceptualized and implemented to enhance the teaching capacity and effectiveness of ALS teachers. Case study was conducted to evaluate the effectiveness of the project. It explored the transfer of life skills among ALS teachers. Data were collected from multiple sources. Interview and written responses, and feedback were analyzed using thematic narrative analysis. Other data were analyzed using document and descriptive analyses. The project had achieved its objectives and rated best by participants. These indicate that the project was implemented effectively and successfully. ALS teachers have acquired life skills and transferred them to others. Thus, the project has made a difference in the lives of these teachers.

Manuel caingcoy

Cancer is one of the most severe medical conditions in the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer requires novel, efficacious treatment modalities. Natural remedies offer feasible alternative options against malignancy in contrast to available synthetic medication. Selective killing of cancer cells is privileged mainstream in cancer treatment, and targeted therapy represents the new tool with the potential to pursue this aim. The discovery of innovative therapies targeting essential components of DNA damage signalling and repair pathways, such as ataxia telangiectasia mutated and Rad3-related Checkpoint kinase 1 (ATR-CHK1), has offered a possibility of significant therapeutic improvement in oncology. The activation and inhibition of this pathway account for chemopreventive and chemotherapeutic activity, respectively. Targeting this pathway can also aid in overcoming the resistance of conventional chemo- or radiotherapy. This review enlightens the anticancer role of natural products by ATR-CHK1 activation and inhibition. Additionally, these compounds have been shown to have chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Ideally, this review will trigger interest in natural products targeting ATR-CHK1 and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed

Natural products the most significant source for pharmaceutical development have been investigated and utilized to alleviate diseases since early human history. Natural compounds from both terrestrial and marine organisms have been extensively used for the treatment of many diseases either in their natural form or as a template for synthetic modification. A variety of new chemical entities from natural resources at present are undergoing clinical trials. The government sector, industries and academic institutions also play an important role in the natural drug development for human health enhancement.

Dr. salman ahmed

Plant secondary metabolites refer to various chemical compounds that plants produce. Still, they are not directly involved in essential growth processes like primary metabolites (such as sugars, amino acids, and lipids). The term "secondary metabolite" has generated controversy, as it implies these compounds are of minor importance to plants. "Special metabolites" may be a more suitable term. These metabolites protect plants from both abiotic and biotic stress. The vast diversity of plant secondary metabolites showcases plants' incredible adaptability and versatility, providing an arsenal of chemical tools to defend against herbivores, protect from pathogens, attract pollinators and seed dispersers, adaptability and thrive in environmental interactions. Plants can, therefore, survive under less-than-ideal conditions. The profound impact of plant secondary metabolites highlights the intricate relationship between plants and humanity, opening doors to innovative applications with far-reaching implications.

Dr. salman ahmed

Libraries play a vital role in providing access to information and fostering lifelong learning in communities. With the rapid advancement of Information Communication Technology (ICT), libraries are embracing digital tools and services to enhance their offerings and extend their reach. In today's interconnected world, the utilization of Information Communication Technology (ICT) resources and services has become imperative for various sectors. This study examines the utilization of ICT-based resources and services by libraries, focusing on key technologies such as digital libraries, online databases, electronic resources, and library management systems. It explores how these technologies enable libraries to expand their collections, improve accessibility, and deliver personalized services to users. The present study is an attempt to examine uses of information communication technology based library resources and services at university of Tamil Nadu. In this paper, the majority of the users' use of ICT based resources and services are study purpose. The majority of the respondents that satisfaction of ICT based resources and services have developed academic skills.

V.murugapandi

Introduction: Obesity has been declared an epidemic that does not discriminate based on age, gender, or ethnicity and thus needs urgent containment and management. Since the third wave of COVID-19 is expected to affect children the most, these children and adolescents should be more cautious while having junk foods, during covid situations due to the compromise of Immunity in the individuals and further exacerbating the organ damage. Methodology: A PAN India survey organized by the Centre for Science and Environment (CSE) among 13,274 children between the ages 9–14 years reported that 93% of the children ate packed food and 68% consumed packaged sweetened beverages more than once a week, and 53% ate these products at least once in a day. Almost 25% of the School going children take ultra-processed food with high levels of sugar, salt, fat, such as pizza and burgers, from fast food outlets more than once a week. Children and adolescents who consume more junk food or addicted to such consumption might be even more vulnerable during the third wave, which will significantly affect the younger category. Conclusion: There is an urgent need to spread awareness among children and young adults about these adverse effects of junk food. There is no better time than now to build a supportive environment nurturing children and young adults in society and promising good health.

Ankul singh

Formulation of the least cost rations that provides the nutrient requirements of birds is an important goal in poultry production . The aim of the present study was to create an application in the Excel program for formulation of low-cost poultry diets that provide adequate nutritional requirements using linear programming based on the Solver function of the Excel program and composition of common feed ingredients used in poultry diets (yellow corn, wheat, soybean meal , barley, wheat bran, protein concentrate, limestone, table salt, di-calcium phosphate, vitamins and minerals premix ,and vegetable oil), if their default prices are 500, 450, 750, 350, 250,1750, 250, 100, 500, 4500,and 1500) Iraqi Dinar / kg, respectively. The results showed that the Solver function in - Excel can be used to solve linear programming models such as those used for formulation of least cost poultry rations. This Microsoft Excel application is ready to use and can be used to assist researchers and students in formulating poultry rations that provide the desired nutritional requirements of poultry at the lowest cost. Key words : Application

Rafea mohammedtaher khulel

Background: Avicenna, as the Persian physician, made a significant contribution to the field of medical sciences, especially surgery, in the 10th and 11th centuries AD. Methods: In the present paper, Avicenna's translated quoted words were shared about his surgical practice. Indexing databases of PubMed and Google Scholar were searched using keywords like Avicenna, surgery, and anesthesiology to find related papers and documents. Results: The first portion comprises some of the most commonly used simple and compound herbal preparations to produce general and local anaesthetics before the surgery and as dental anaesthetic agents. In the second portion, practices regarding surgical management for skull fractures, spinal trauma, bone fractures, cataracts, incurable urinary retention, bladder calculi, haemorrhoids, cancer, as well as endotracheal intubation and tracheostomy, have also been incorporated. Finally, it ends up with practices regarding the use of natural products as postoperative dressing for traumatic and surgical wounds and after cataract surgery. Conclusion: Based on the recent investigations, the findings of this review study will provide a brief insight into Avicenna’s Canon of Medicine and the sciences of anesthesiology and surgery.

Dr. salman ahmed