Perioperative Medicine articles list

India is a country of immense diversity. It is home to people of many different racial, languages, ethnic, religious, and national backgrounds. Groups of people in India differ from each other not only in physical or demographic characteristics but also in distinctive patterns of behavior and these patterns are determined by social and cultural factors like language, region, religion, and caste. Apart from behaviour, economic development, level of education and political culture of the people in various social segments differ from region to region. More you can say that economy and cultures have been enriched by the contributions of migrants from round the globe. In an increasingly globalised world, migratory movements is continuously shaping the countries all over the world. Some countries like India and Ireland, which set the example of economic development and social integration, have the positive impact of the migration by globalisation and some countries like USA, which recently witness racism, xenophobia and discrimination have the negative impact on the migrants. It does not mean India do not face fragmentation and USA do not have cohesion. USA have many stories which show successful integration process, that facilitated the lives of immigrant communities, but being a developed country it still suffers from cultural alienation. In these countries, borders are built within borders to create cultural divides that do not allow people to integrate. Recently, this problem has become more prominent due to the rise of terrorism, clash of cultures in the world, leading to the glorification of stereotypes. People are becoming less accepting towards anyone who does not belong to their region. Migration does not stop after people move from one place to another place. The main question start after that ‘now what’ they will do. That is why this topic needs to be discussed thoroughly in order to find better solutions. This paper will begin with an analysis of different approaches to Migration, discuss the target groups for integration policies, provide indicators of the current situation of migrants and proceed to an analysis of integration tools: legislation, social policies and participatory processes. It will focus not only on the impact of migration but also on social integration, mix culture like indo-western culture in a comparative basis.

Ekta Meena

India is a country of immense diversity. It is home to people of many different racial, languages, ethnic, religious, and national backgrounds. Groups of people in India differ from each other not only in physical or demographic characteristics but also in distinctive patterns of behavior and these patterns are determined by social and cultural factors like language, region, religion, and caste. Apart from behaviour, economic development, level of education and political culture of the people in various social segments differ from region to region. More you can say that economy and cultures have been enriched by the contributions of migrants from round the globe. In an increasingly globalised world, migratory movements is continuously shaping the countries all over the world. Some countries like India and Ireland, which set the example of economic development and social integration, have the positive impact of the migration by globalisation and some countries like USA, which recently witness racism, xenophobia and discrimination have the negative impact on the migrants. It does not mean India do not face fragmentation and USA do not have cohesion. USA have many stories which show successful integration process, that facilitated the lives of immigrant communities, but being a developed country it still suffers from cultural alienation. In these countries, borders are built within borders to create cultural divides that do not allow people to integrate. Recently, this problem has become more prominent due to the rise of terrorism, clash of cultures in the world, leading to the glorification of stereotypes. People are becoming less accepting towards anyone who does not belong to their region. Migration does not stop after people move from one place to another place. The main question start after that ‘now what’ they will do. That is why this topic needs to be discussed thoroughly in order to find better solutions. This paper will begin with an analysis of different approaches to Migration, discuss the target groups for integration policies, provide indicators of the current situation of migrants and proceed to an analysis of integration tools: legislation, social policies and participatory processes. It will focus not only on the impact of migration but also on social integration, mix culture like indo-western culture in a comparative basis.

Ekta Meena

In this paper, investigations are made to analyze the human body temperature during wound healing process due to surgery. Wound is considered after the skin graft. Skin graft is a technique used in plastic surgery. Skin is the first line of defense between the human and environment, it is very susceptible to damage. Internal body or core temperature (Tb) is one of the clinical vital signs along with pulse and respiratory rates. Any disturbance in body temperature will drive complexities in wound healing process. These studies are important in the mechanism of establishing the limits of thermal regulation of human body during the healing process in different situations and conditions. The Finite element method is used to analyze tissues temperature for normal tissues (donor site) and abnormal tissues (tissues after surgery). Appropriate boundary conditions have been framed. Numerical results are obtained using Crank Nicolson Method.

Manisha Jain

Physically unclonable function (PUF) is a hardware security module preferred for hardware feature based random number and secret key generation. Security of a cryptographic system relies on the quality of the challenge-response pair, it is necessary that the key generation mechanism must unpredictable and its response should constant under different operating condition. Metastable state in CMOS latch is undesirable since it response becomes unpredictable, this feature used in this work to generate a unique response. A feedback mechanism is developed which forces the latch into the metastable region; after metastable state, latch settle to high or state depends on circuit internal condition and noise which cannot be predicted. Obtained inter hamming variation for 8 PUF is 51% and average intra hamming distance is 99.76% with supply voltage variation and 96.22% with temperature variation.

Abhishek Kumar

One of the unique features of Indian society is prevalence of caste system which was originated thousands of years back to demarcate the people engaged in different occupation or jobs. Initially it was not much rigid but gradually people belonging to upper castes for their own selfish means to maintain their monopoly made this arrangement hereditary and started treating people of lower castes disgracefully. For preservation of this system, people started controlling their women to prevent inter-caste marriages and the concept of endogamy came up. This robbed away many types of freedom from women. For women belonging to lower castes, this situation is worse as they are doubly subjugated on the basis on caste as well as gender. Men belonging to their own caste treat them as secondary beings. This paper throws light on this intersection. How intersection of these two kinds of inequalities place them at the lowest position in Indian society. Dr. B.R. Ambedkar rises as their leader who all his life worked for empowerment of downtrodden section of society. He argues that education is the primary tool for evading these differences among people. He further emphasizes to adopt the concept of exogamy to break the backbone of Indian caste system and to immediately leave a religion or culture which legitimizes such system of inequality among people of the same land.

Swati sharma

One of the unique features of Indian society is prevalence of caste system which was originated thousands of years back to demarcate the people engaged in different occupation or jobs. Initially it was not much rigid but gradually people belonging to upper castes for their own selfish means to maintain their monopoly made this arrangement hereditary and started treating people of lower castes disgracefully. For preservation of this system, people started controlling their women to prevent inter-caste marriages and the concept of endogamy came up. This robbed away many types of freedom from women. For women belonging to lower castes, this situation is worse as they are doubly subjugated on the basis on caste as well as gender. Men belonging to their own caste treat them as secondary beings. This paper throws light on this intersection. How intersection of these two kinds of inequalities place them at the lowest position in Indian society. Dr. B.R. Ambedkar rises as their leader who all his life worked for empowerment of downtrodden section of society. He argues that education is the primary tool for evading these differences among people. He further emphasizes to adopt the concept of exogamy to break the backbone of Indian caste system and to immediately leave a religion or culture which legitimizes such system of inequality among people of the same land.

Swati sharma

The anti-emetic activity of the leaves methanolic extracts of Cassia angustifolia Vahl., Cassia holosericea Fresen., Cassia italica Miller. Lam. ex F.W. Ander and Cassia purpurea Roxb., was evaluated in young chicks. Emesis was induced by copper sulfate (50 mg/kg), and the extracts were tested orally at a dose of 150 mg/kg. All the extracts significantly decreased the number of retching (p < 0.05 and p < 0.01) compared with standard chlorpromazine.

Dr. Salman Ahmed

The current study was designed to explore the antiemetic effect of the methanolic extracts of Acalypha fimbriata Schumach. & Thonn., Acalypha ornata Hochst., and Acalypha wilkesiana cv. godseffiana Muell Arg., aerial parts using chick emesis model to validate their folk use in G.I. disorders. Emesis was induced by the oral administration of copper sulfate to male chicks. All the extracts (150 mg/kg orally) showed an antiemetic effect and were compared with the reference drug chlorpromazine. Among all the extracts, Acalypha ornata Hochst., leaves extract showed the highest (94.51%) and Acalypha fimbriata Schumach. & Thonn., stem extract showed the lowest (35.04%) antiemetic effect.

Dr. Salman Ahmed

The current study was conducted to explore the antiemetic activity of two marine algae, Iyengaria stellata Børgesen (Phaeophycota) and Valoniopsis pachynema Børgesen (Chlorophycota), by chick emesis model. Emesis was induced by copper sulphate (50 mg/kg), and the extracts were tested orally at 150 mg/kg. Chlorpromazine (150 mg/kg orally) was used as a standard antiemetic drug. The results showed that methanol extracts of both seaweeds have antiemetic activity.

Dr. Salman Ahmed

Ethanol and hexane extracts of the leaves and male flowers of Luffa cylindrica were evaluated for antiemetic and anti-inflammatory effects using chick emesis model and carrageenan-induced rat paw oedema. The antiemetic effect was observed at 150 mg/kg body weight, whereas the anti-inflammatory effect was observed at doses of 500,750 and 1000 mg/kg body weight orally. Chlorpromazine 150 mg/kg and indomethacin 10mg/kg orally were used as standard antiemetic and anti-inflammatory drugs. The antiemetic effect was determined by calculating the mean decrease in the number of retching compared to the control group after 10 minutes of copper sulfate (50 mg/kg orally) administration. The degree of paw oedema of all the groups was measured using a plethysmometer at the 5th hour of carrageenan (1% w/v) administration. All extracts except hexane extract of leaves exhibited statistically significant (P<0.001) antiemetic and except hexane extract of flower, all extracts exhibited statistically significant (P<0.05) anti-inflammatory effects.

Dr. Salman Ahmed

Cleome brachycarpa Vahl . and Cleome viscosa L. were evaluated for anti-emetic activity in the copper sulfate-induced chick emesis model. Emesis was induced by copper sulfate (50 mg/kg), and the methanolic extracts of leaves were tested orally at a dose of 150 mg/kg. Chlorpromazine (150mg/kg orally) was used as standard anti-emetic drug. The anti-emetic activity was determined by calculating the mean decrease in the number of retching as compared with the control. Cleome brachycarpa and Cleome viscosa showed comparable anti-emetic activity with chlorpromazine.Cleome brachycarpa Vahl ., and Cleome viscosa L., leaves extract in a dose of 150 mg/kg body weight., reduced the numbers of retches by 57.57% and 43.06%. Cleome brachycarpa significantly (**P<0.005) reduced the number of retches. The group of chicks treated with chlorpromazine had 45 retches compared to the 71 retches of the control group, thus chlorpromazine reduced the retches by 36.99%. From the results, it is clear that Cleome brachycarpa Vahl. and Cleome viscosa L. leaves extracts have antiemetic potential and are comparable with standard chlorpromazine. Although the result is significant the mode of action is not known. Antiemetic activity by using copper sulfate proposed 5-HT3, 5-HT4, or NK1 receptor antagonism. Therefore, the extracts effectively prevented its effect and had a peripheral anti-emetic action. As mentioned earlier, triterpenoids such as brachycarpone, deacetoxybrachycarpone, cabralealactone and ursolic acid are reported from Cleome brachycarpa6, whereas flavonoids are reported from Cleome viscosa. Flavonoids and triterpenoids possess anti-emetic properties18. So, if flavonoids and triterpenoids are present in the studied extracts, the observed anti-emetic effects may be due to flavonoids and triterpenoids. The present study is on the preliminary level, and further investigation is required to confirm the anti-emetic effect of Cleome brachycarpa Vahl ., and Cleome viscosa L. leaves and determine the compounds responsible for this activity with their possible mode of action.

Dr. Salman Ahmed

Emesis, also known as nausea and vomiting, are common symptoms associated with ingestion of toxicants, drug side effects, advanced terminal diseases such as cancer and postoperative procedures. Emesis is mediated through the coordinated action of central and peripheral regulatory centres that involve receptors including dopamine Type 2, serotonin, muscarinic cholinergic, histamine, cannabinoids and NK-1 receptors. Many anti-emetic drugs targeting these receptors are currently in use, but they also cause undesirable side effects such as excessive sedation, hypotension, dry mouth, dysphoria, hallucinations and extrapyramidal signs. This review highlights the pharmacological mechanism of emesis, current antiemetic drugs, and a detailed analysis of in vitro and in vivo anti-emetic bioassay models. The pharmacology of crude natural products extracts and purified anti-emetic compounds (cannabinoids, chalcones, diarylheptanoids, flavonoids, hydroxycinnamic acids, lignans, phenylpropanoids, polysaccharides, saponins, terpenes and glycosidic derivatives) are also systematically presented with their mechanism of action. The potential of natural products as sources of new clinically proven anti-emetic drugs is discussed.

Dr. Salman Ahmed

The current study used the chick emesis model to explore the anti-emetic effect of the methanolic extract of Acalypha ornata Hochst—roots. Emesis was induced by the oral administration of copper sulfate to male chicks. Acalypha ornata root extract (150 mg/kg orally) showed an anti-emetic effect and was compared with the reference drug chlorpromazine

Dr. Salman Ahmed

The current study was designed to explore the antiemetic effect of the methanolic extract of Tithonia diversifolia (Hemsl.) A. Gray., leaves using chick emesis model to validate their folk use in G.I. disorders. Emesis was induced by the oral administration of copper sulfate 50mg/kg body weight to male chicks of four days of age. The antiemetic activity was determined by calculating the mean decrease in the number of retching compared to the control. Tithonia diversifolia leaves extract (150 mg/kg orally) showed a significant (p <0.05) antiemetic effect and was compared with the reference drug chlorpromazine.

Dr. Salman Ahmed

Ethanol extract of Luffa cylindrica (L.) Roem. Fruit peel was evaluated for antiemetic and anti-inflammatory effects using the chick emesis model and carrageenan-induced rat paw edema. The antiemetic effect was observed at 150 mg /kg body weight whereas the anti-inflammatory effect was observed at doses of 500, 750 and 1000 mg /kg body weight orally. Chlorpromazine 150mg/kg and indomethacin 10mg/kg orally were used as standard anti-emetic and anti-inflammatory drugs. The anti-emetic effect was determined by calculating the mean decrease in the number of retchings compared to those of the control group after 10 minutes of copper sulfate (50mg/kg orally) administration. The degree of paw oedema of all the groups was measured using a plethysmometer at the 5th hour of carrageenan (1% w/v) administration. The extract exhibited statistically significant anti-emetic (P< 0.001) and anti-inflammatory (P< 0.05) effects.

Dr. Salman Ahmed

Emesis encompasses the forceful expulsion of the stomach's contents via the mouth or sometimes the nose. The adverse effects of currently available anti-emetic agents potentiate the natural product researchers to explore natural anti-emetics with fewer side effects. The presented communication reviews the anti-emetic effect of two hundred and forty-five plants belonging to seventy-eight families in different parts of the world. It also outlined the anti-emetic effect of plant extracts and isolated secondary metabolites studied through a variety of animal models of emesis. The reported anti-emetic plants in different countries and cultures and the scientific studies on extracts may help in the identification of promising single chemical compound(s) that may be used as potential leads for developing safe anti-emetic agents in future. Moreover, the reported secondary metabolites having the same effect may open the door for the search for the same secondary metabolites from other natural sources. This review will provide useful information for discovering natural anti-emetic compounds and fill the gaps in knowledge.

Dr. Salman Ahmed

The present investigation is an attempt to evaluate the analgesic and antiemetic activities of Ficus exasperata and Cleome ciliata leaves methanolic extract by using the chick emesis model (oral treatment) and acetic acid-induced writhing test (intraperitoneal treatment) in mice, respectively. The antiemetic activity (150 mg/kg b.w., of extract) was carried out by using chlorpromazine (150mg/kg) as standard antiemetic drug. The analgesic activity (250 mg/kg b.w. of extract) was performed using aspirin (150mg/kg) as a standard analgesic drug. The results showed significant analgesic and antiemetic effects.

Dr. Salman Ahmed

The presented study initially attempted to discover bergenin as an antiemetic compound isolated from Peltophorum roxburghii L. leaves. It is the extension of antiemetic activity from the methanol extract of Peltophorum roxburghii L. leaves. The antiemetic activity was assessed using copper sulfate-induced emesis in the chick’s model. Bergenin (25 mg/kg, p.o.) exhibited significant antiemetic activity compared to the standard drug, chlorpromazine. This is the first time that bergenin has declared antiemetic activity. Bergenin has already been evaluated positively for its anti-inflammatory activity, and this paper will report its antiemetic activity. Both the activities of the same compound may be beneficial for drug design against the disease, as they have anti-inflammatory and antiemetic symptoms like migraines. The preliminary antiemetic evaluation of bergenin was conducted on a single dose due to the low yield of Bergenin. However, the result was significant in terms of the standard used. Further, the isolation and purification of Bergenin are in the process of establishing detailed data on different doses of Bergenin.

Dr. Salman Ahmed

Emesis is defined as a forceful expulsion of stomach contents via the mouth. The adverse effects of available anti-emetic drugs potentiate us to evaluate natural products to explore effective natural anti-emetics with fewer side effects. The fruits of Illicium verum Hook. f. were selected for anti-emetic activity based on their folkloric use against gastrointestinal complaints. Crude methanolic extract and its aqueous, dichloromethane, ethylacetate and hexane fractions were evaluated using the copper sulphate-induced chick emesis model. Emesis was induced by the oral administration of copper sulfate 10 ml/kg body weight and metoclopramide (150 mg/kg p.o.) as a standard anti-emetic drug. The anti-emetic effect was observed by calculating the mean decrease in the number of retches compared to that of the control. Methanolic extract and its fractions were tested at 25, 50 and 75 mg/kg oral doses. Among all tested fractions, ethyl acetate showed the highest (94.46%), and hexane showed the lowest (56.30%) anti-emetic activity at 50 mg/kg. Further, isolation and purification from the same fractions are in process to discover effective natural anti-emetic compound(s) with less unwanted effects.

Dr. Salman Ahmed