Dr. Salman Ahmed

Phytochemical analysis and anti-emetic activity of illicium verum hook. f. fruit by chick emesis model

• Authors Details :  
• Alya Maimoona,  
• Fareeha Iqbal,  
• Qurat-ul-ain Syed ,  
• Salman Ahmed

277 Views Original Article

Emesis is defined as a forceful expulsion of stomach contents via the mouth. The adverse effects of available anti-emetic drugs potentiate us to evaluate natural products to explore effective natural anti-emetics with fewer side effects. The fruits of Illicium verum Hook. f. were selected for anti-emetic activity based on their folkloric use against gastrointestinal complaints. Crude methanolic extract and its aqueous, dichloromethane, ethylacetate and hexane fractions were evaluated using the copper sulphate-induced chick emesis model. Emesis was induced by the oral administration of copper sulfate 10 ml/kg body weight and metoclopramide (150 mg/kg p.o.) as a standard anti-emetic drug. The anti-emetic effect was observed by calculating the mean decrease in the number of retches compared to that of the control. Methanolic extract and its fractions were tested at 25, 50 and 75 mg/kg oral doses. Among all tested fractions, ethyl acetate showed the highest (94.46%), and hexane showed the lowest (56.30%) anti-emetic activity at 50 mg/kg. Further, isolation and purification from the same fractions are in process to discover effective natural anti-emetic compound(s) with less unwanted effects.

Article Subject Details

• Perioperative medicine
• Pharmaceutical analysis
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• Chlorpromazine
• Anti-emetic
• Chicks
• Copper sulfate induced vomiting
• Pharmacognosy
• Pharmacology
• Pharmacy
• Phytochemical analysis

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