Dr. Salman Ahmed
Anti-emetic and anti-inflammatory activity of fruit peel of luffa cylindrica (l.) roem
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Ethanol extract of Luffa cylindrica (L.) Roem. Fruit peel was evaluated for antiemetic and anti-inflammatory effects using the chick emesis model and carrageenan-induced rat paw edema. The antiemetic effect was observed at 150 mg /kg body weight whereas the anti-inflammatory effect was observed at doses of 500, 750 and 1000 mg /kg body weight orally. Chlorpromazine 150mg/kg and indomethacin 10mg/kg orally were used as standard anti-emetic and anti-inflammatory drugs. The anti-emetic effect was determined by calculating the mean decrease in the number of retchings compared to those of the control group after 10 minutes of copper sulfate (50mg/kg orally) administration. The degree of paw oedema of all the groups was measured using a plethysmometer at the 5th hour of carrageenan (1% w/v) administration. The extract exhibited statistically significant anti-emetic (P< 0.001) and anti-inflammatory (P< 0.05) effects.
Article Subject Details
- Pain medicine
- Perioperative medicine
- Pharmaceutical sciences
- Pharmacognosy
- Pharmacology
- Pharmacology and toxicology
- Pharmacy
Article Keywords Details
- Chlorpromazine
- Anti-emetic
- Anti-inflammatory
- Chicks
- Copper sulfate induced vomiting
- Pharmacognosy
- Pharmacology
- Pharmacy
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