Dr. Salman Ahmed

Analgesic and anti-inflammatory effects of phaseolus vulgaris l. fixed oil in rodents

• Authors Details :  
• Salma,  
• Sadia Ghousia Baig,  
• Muhammad Mohtasheem Ul Hasan,  
• Salman Ahmed,  
• Syeda Anum Fatima

Journal title : Journal of Basic & Applied Sciences

Publisher : Set Publishers

Print ISSN : 1814-8085

Page Number : 174-179

Journal volume : 14

350 Views Original Article

The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked to anticancer, antihyperlipidemic, hypoglycemic, and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan-induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetylsalicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg doses demonstrated analgesic and anti-inflammatory activities, but in hot plate, results were unreliable as significant activity started after 90 minutes. A 5ml/kg dose was administered orally in mice for a toxicity test, and no toxicity symptoms were observed. Therefore, PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.

Article DOI & Crossmark Data

DOI : https://doi.org/10.6000/1927-5129.2018.14.26

Article Subject Details

• Health Science
• Medicine
• Neuropharmacology
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• Analgesic
• Anti-inflammatory
• Fixed oil
• Pharmacognosy
• Pharmacology
• Pharmacy
• Phaseolus vulgaris
• Rodents

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Article References

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