Biophysics

eISSN : 1555-6654

Publisher : Pleiades Publishing Ltd

Website : link.springer.com

The effects of severe hypobaric hypoxia and inhibition of hypoxia-inducible factor-1 (hif-1) on biomarkers of cardiac and skeletal muscle injury in rats

The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated more...