Archana Mehrotra
Preparation and physicochemical and in-vitro evaluation of lomustine nanoparticles
19 Views Original Article
In the present study nanoparticles of lomustine were fabricated using chitosan polymer crosslinked with different crosslinking agents like sodium tripolyphosphate and sodium hexametaphosphate. Different formulations of nanoparticles were prepared using different concentrations of crosslinking agents and polyethylene glycol 6000. The average particle size ranged between 112 nm to 942 nm. Zeta potential of nanoparticles ranged between 29.0 mV up to 56.0 mV. Encapsulation efficiency was variable from 58%-96%. The nanoparticles were solid spherical. In vitro drug release study was carried out in phosphate buffered saline solution pH 7.4 for 10 h. The analysis of regression values of Higuchi plot suggested diffusional mechanism and follows Fick's law of diffusion. Drug polymer interaction was absent as evidenced by FT-IR spectra and DSC thermograms. With polyethylene glycol inclusion shows interaction between lomustine and PEG. Cell viability assay (MTT Assay) showed that the lomustine nanoparticles were able to reduce the tumour cell proliferation and increased cell viability significantly (p< 0.05) as compared to pure drug in L 132 human lung cancer cell line
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Archana Mehrotra
The aim of this work was to prepare chitosan nanoparticles loaded with antineoplastic drug lomustine (lcnps), by ionic-gelation method with homogenization. the nanoparticles were c...
This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reduc...
The incorporation of lomustine, a hydrophobic anticancer drug into plga nanoparticles by interfacial deposition method was optimized. based on the optimal parameters, it was found ...
This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reduc...