Dr. Salman Ahmed
Marine peptides in breast cancer: therapeutic and mechanistic understanding
Journal title : Biomedicine & Pharmacotherapy
Publisher : Elsevier BV
Print ISSN : 0753-3322
Page Number : 112038
Journal volume : 142
292 Views Reviews Article
Breast cancer is the most prevalent invasive form of cancer in females and poses a significant challenge to overcoming the disease burden. The growth in global cancer deaths mandates the discovery of new efficacious natural anti-tumor treatments. In this regard, aquatic species offer a rich supply of possible drugs. Studies have shown that several marine peptides damage cancer cells by a broad range of pathways, including apoptosis, microtubule balance disturbances, and suppression of angiogenesis. Many side effects, including immune response suppression, characterise traditional chemotherapeutic agents. The discovery of novel putative anti-cancer peptides with lesser toxicity is therefore necessary and timely, especially those able to thwart multi-drug resistance (MDR). This review addresses marine anti-cancer peptides for the treatment of breast cancer.
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DOI : https://doi.org/10.1016/j.biopha.2021.112038
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