Mediterranean Journal Of Pharmacy And Pharmaceutical Sciences
Evaluation of some metformin hydrochloride brands available in the libyan market
482 Views Short Communication
Various quality control tests are employed for solid dosage forms such as uniformity, dissolution and drug contents in order to assess their pharmaceutical equivalence. The objective of the current study was to assess and contrast five distinct metformin hydrochloride brands that are offered for sale in the Libyan market. The physicochemical equivalence of the five brands of metformin hydrochloride tablets (500 mg) were determined through the evaluation of official and non-official standards according to the USP including uniformity of weight, friability, hardness, dissolution rate and drug content. All the examined brands available in the Libyan market passed the official weight variation, friability, dissolution and disintegration tests and were equivalent. The friability test was found within the specified limit. All the formulations were disintegrated within 09 - 15 min. The tested brands were non-equivalent to the innovator Glucophage® according to their dissolution evaluation. The percentage content of the active ingredient of five brands of metformin tablets showed values within the monograph specifications (95% - 105%). In conclusion, all the five brands available in the Libyan market which were evaluated in this study cannot be substituted with the innovator product in clinical practice.
Article DOI & Crossmark Data
DOI : https://doi.org/10.5281/zenodo.7479690
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
The current covid-19 is now endemic on everycontinent and becomes the most challenging outbreaks over centuries, thus millions of people have been infected with the novel coronavir...
It is with more sorrow and tremendous sadness we remember the death of our colleague the libyan pharmacist, professor mokhtar ramadan haman, at his home in tripoli, libya after lon...
The 2019 coronavirus (covid-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. molecular docking is a ...
Plants are an ancient source of medicine due to the presence of bioactive molecules of various compounds in their different parts. convolvulus dorycnium plant belongs to the family...