Pharmacology articles list

Urolithiasis is a common worldwide problem with high recurrence. This review covers forty four (44) families starting from alphabet A to L and includes Bignoniaceae (05); Araceae, Burseraceae, Combretaceae (04); Annonaceae, Berberidaceae, Betulaceae, Gentianaceae, Gesneriaceae (03); Aizoaceae, Adiantaceae, Alismataceae, Aristolochiaceae, Asclepiadaceae, Bombacaceae, Cannabaceae, Cyperaceae, Geraniaceae and Iridaceae (02); Acoraceae, Adoxaceae, Armatellaceae, Aquifoliaceae, Araliaceae, Averrhoeaceae, Basellaceae, Begoniaceae, Bromeliaceae, Cactaceae, Calophyllaceae, Campanulaceae, Caprifoliaceae, Caricaceae, Celastraceae, Clusiaceae, Dracaenaceae, Dryopteridaceae, Elaeagnaceae, Grossulariaceae, Hyacinthaceae, Hydrangeaceae, Hypoxidaceae, llecebraceae and Juglandaceae (01) plant used globally in different countries. The plants of three families Asteraceae, Fabaceae and Lamiaceae are revisited to provide updated information. This review will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery.

Dr. Salman Ahmed

Monosodium urate monohydrate crystals are deposited in peripheral joints, causing gout and eliciting an intense localized inflammatory attack. In contrast, collecting ducts and medullary interstitium is a urinary calculus, which causes dysuria, nausea and hematuria. The purpose of the present study is to observe possible growth patterns of monosodium urate monohydrate crystals. The crystals were grown in test tubes using a single diffusion gel technique and were observed on the 7th,14th, 21st, 28th, and 40th days. Needle and spherulite-type crystals were observed on the 14th day, while arboresque, crystal sheaves, densely branched, dumbbell, mushroom-type spherulites, plumose and hexagonal prismatic crystals were observed for the first time. After the 40th day, complete spherulites were observed with their aggregates. The crystals were characterized by Scanning Electron Microscopy, Energy-Dispersive X-ray and Fourier Transform infrared spectroscopies. The pattern of MSUM will help determine the role of different natural products in the modulation, inhibition or promotion of these crystals by affecting the shape, size, transparency, approximate number and total mass of growing crystals. In case of inhibition or modulation, it will help evaluate prophylactic management. In contrast, the promotion of the crystal will give an idea about the risk factors of gout and kidney stones.

Dr. Salman Ahmed

Arisaema jacquemontii Blume (Araceae) is a medicinally important plant for treating different diseases, especially dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, and tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. Salman Ahmed

: Analgesic, anti-inflammatory and diuretic activities of the methanol extract of two varieties of Cicer arietinum viz black or Desi and white or Kabuli were tested in 200 and 400 mg/kg doses. For the analgesic effect of the extracts, acetic acid-induced writhing, tail immersion and hot plate tests were employed in mice. The anti-inflammatory activity was carried out by carrageenan-induced inflammation in rats, whereas the diuretic action was determined using metabolic cages for rats. Animals were divided into six groups (n=7): (1) Control (2) Standard (3) MECAB 200 (4) MECAB 400 (5) MECAW 200 (6) MECAW 400. All extracts and standard drugs were administered orally. Acute oral toxicity of the extracts was also checked in mice up to 2000mg/kg dose, which showed a favorable safety. Significant analgesic and anti-inflammatory effects were observed. The results of diuretic activity were significant at the 12th and 24th hrs. Therefore, it is concluded that the methanol extracts of the seeds of Cicer arietinum have analgesic, anti-inflammatory and diuretic potential.

Dr. Salman Ahmed

Macrotyloma uniflorum, commonly known as horse gram or kulthi bean, is grown as a pulse for livestock and human consumption. The beans contain about 1.3% fat, 18% protein, 15% carbohydrate, and vitamins and minerals. Traditional medicine uses it as an antihyperglycemic, antioxidant, antihypertensive and diuretic. Other important medicinal uses include the treatment of renal stones, obesity, piles, oedema and fever. The present study evaluated analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and anti-inflammatory (carrageenan-induced paw oedema in rats) activities of Macrotyloma uniflorum fixed oil (MUFO). Four groups were included in the study: Group I: Normal Saline Control (2ml/kg), Group II: MUFO (2ml/kg), Group III: MUFO (4ml/kg), and Group IV: Standard Acetyl salicylic acid (ASA 300mg/kg). All results were significant; however, the tail flick and paw oedema tests observed a delayed onset of action. The oil's acute oral toxicity was also checked in mice and was found safe up to a 4ml/kg dose, as no signs of toxicity and mortality were observed. It is concluded that Macrotyloma uniflorum fixed oil may possess analgesic and anti-inflammatory activity, which can be related to a peripheral mechanism of action.

Dr. Salman Ahmed

Phycochemical and pharmacological studies were carried out on Ulva fasciata Delile. The ash content was found to be 20.4812 % dry weight, moisture content 14.5514 %, and total fat content as 0.1878% and 0.49341 %. Total carbohydrate was found to be 54.5301-54.2246% dry weight, phenolic content was found to be 0.022%, flavonoids were found to be 0.0313%, and tannins were 0.00003 %. Ulva fasicata showed central analgesic activity and significant anti-inflammatory activity at 400 mg/kg bw.

Dr. Salman Ahmed

Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Dr. Salman Ahmed

The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked to anticancer, antihyperlipidemic, hypoglycemic, and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan-induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetylsalicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg doses demonstrated analgesic and anti-inflammatory activities, but in hot plate, results were unreliable as significant activity started after 90 minutes. A 5ml/kg dose was administered orally in mice for a toxicity test, and no toxicity symptoms were observed. Therefore, PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.

Dr. Salman Ahmed

Macrotyloma uniflorum (Lam.) Verdc. (Papilionaceae) is commonly known as Horse gram and Kulthi. The seeds are reported as anthelmintic, diaphoretic, diuretic and emmenagogue. It is also useful for asthma, bronchitis, and urolithiasis. The present study evaluated the analgesic, anti-inflammatory and diuretic effects of the methanol extract of Macrotyloma uniflorum seeds in 200 and 400mg/kg doses. Significant results were obtained in all activities.

Dr. Salman Ahmed

About 12% of the world's population is affected by different forms of urolithiasis, of which the recurrence rate in females is 47–60% and in males is 70–80%. Standard therapeutic agents (allopurinol, citrate, cystone and thiazide diuretics) prevent and treat urolithiasis. Still, these are not universally-effective due to common kidney stone relapse and other side effects. Surgical treatment causes long-term renal damage, hypertension and stone recurrence. Polyphenols, the plant-derived bioactive molecules, have showed protection against cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases, among several other ailments. The role of these phytochemicals in urolithiasis management is emerging. Hence, the present review discusses peer-reviewed published literature to date on this aspect and highlights that polyphenols could effectively inhibit the formation of calcium oxalate urinary stones (most common renal stone), correlating with their antioxidant, anti-inflammatory, diuretic and angiotensin-converting enzyme (ACE) inhibition. Further, we have proposed the prospects and challenges in developing plant polyphenols into drugs against kidney stone prevention. This review might be a stepping stone for further investigation into the clinical implications of polyphenols in urolithiasis remediation.

Dr. Salman Ahmed

Background: Breast cancer is a commonly found malignancy worldwide in women, and effective treatment is regarded as a substantial clinical challenge even in the presence of several options. Extensive literature is available that demonstrates polyphenols, the richly introduced phytopharmaceuticals, as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, and curcumin are reported to have tremendous potential against breast cancer. However, till now, no comprehensive survey has been found about the anticarcinogenic properties of luteolin against breast cancer. Scope and approach: This review targeted the available literature on luteolin in the treatment of breast cancer, its effects in combination with other anticancer drugs, and possible mechanisms. Key findings and conclusion: Lutein's outstanding therapeutic potential in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent but also complemented by its synergistic effects with other anti-cancer therapies such as cyclophosphamide, doxorubicin, and NSAIDs such as celecoxib and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.

Dr. Salman Ahmed

The genus Caesalpinia belongs to the family Caesalpiniaceae and includes 280 species distributed in tropic and subtropical regions of the world. Historically, species of the genus Caesalpinia have been used to treat a wide range of ailments, such as malaria, ascariasis, dysentery, fever, rheumatism, and influenza. Phytochemical works led to the isolation of triterpenoids, diterpenes, flavonoids, steroids and phenolic compounds. Pharmacological studies have shown that the extracts and compounds isolated from this genus exhibited anticancer, anti-inflammatory, anti-malarial, antipyretic, anti-microbial, anti-rheumatic, antiulcer and anti-diabetic activities. Therefore, this review aims to provide a comprehensive overview of the genus Caesalpinia's ethnopharmacology, phytochemistry and pharmacology.

Dr. Salman Ahmed

Fragaria nubicola (Hoof. f) Linn. (Rosaceae) is a medicinally important plant commonly called Wild strawberry. Traditionally, it has been used to treat different diseases. The study was carried out to compile all the previous data in review form based on its distribution, traditional medicinal uses, pharmacology and phytochemistry

Dr. Salman Ahmed

Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative medicine for treating neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin, and naringin (NRG), have been shown to possess promising potential in treating neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.

Dr. Salman Ahmed

Cardiovascular disorders are known as one of the leading health problems which are associated with mortality worldwide. Myocardial ischemia (MI) is the improper blood supply to the myocardium, which leads to severe complications to life-threatening problems like AMI, atherosclerosis, hypertension, cardiac hypertrophy, as well as diabetic-associated complications such as diabetic atherosclerosis/cardiomyopathy/hypertension. Despite several efforts, the current therapeutic platforms are unrelated to significant results. Hence, it seems that developing novel therapies is required. Increasing evidence indicates that curcumin (CRC) acts as a cardioprotective agent. Given that CRC and its analogues exert their cardioprotective effects via affecting various cardiovascular disease-related mechanisms (i.e., Inflammation and oxidative stress). Herein, we have highlighted the protective impacts of CRC against MI for the first time. This review might be a stepping stone for further investigation into the clinical implications of the CRC against MI. Furthermore, it highlights a legitimate concern for the scientific community, seeking novel techniques and characteristic dynamic biopharmaceuticals against myocardial ischemia.

Dr. Salman Ahmed

Anti-emetic activity Of four aromatic medicinal plants (Curcuma caesia Roxb., Piper longum Linn., Piper nigrum Linn., and Syzygiunt aromaticum (Linn.) Merr. & Perry) was studied in chicks. The ethanol extracts of these plants were administered at 150 mg/kg BW orally. All the extracts showed a significant (P < 0.05) decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg /kg BW. Domperidone was given at 100 mg/kg as a reference drug.

Dr. Salman Ahmed

The current study explored the anti-emetic activity of six aromatic medicinal plants viz Carissa carandus L.. Cichorium intybus Cinnamomum tamala L.. Lallemantia royleana Benth. Matricaria chamomilla L., and Piper metysticum G. Forst . Anti-emetic activity was assessed using a chick as an anti-emetic model. The ethanol extracts of these plants were administered at 150 mg/kg BW orally. Lallemantia royleana and Piper metysticum showed a significant (P <0.001 ) decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg/kg BW. Domperidone was given at 100 mg/kg as a reference drug.

Dr. Salman Ahmed

The current study was designed to explore the anti-inflammatory effects of the crude hexane and ethanol extracts of the leaves and male flowers of Luffa cylindrica (L.) Roem., (sponge gourds) to validate its folk use. These extracts produced significant anti-inflammatory effects (p.o.) at doses of 500, 750 and 1000 mg/kg b.w. in carrageenin-induced paw oedema in rats compared to those obtained with indomethacin. The results of the present study provide evidence for the anti-inflammatory properties of the leaves and male flowers of Luffa cylindrica, which have potential therapeutic applications for inflammatory diseases.

Dr. Salman Ahmed

The analgesic activity Of the crude hexane and ethanol extracts of the leaves and male flowers of Luffa cylindrica (L.) Roem., (sponge gourds) was carried out at dose of 500 mg /kg b.w., (p.o.) in mechanically induced pain in rats by using analgesy-meter. These extracts produced significant analgesic effect results of the present study revealed the analgesic properties of the leaves and male flowers of Luffa cylindrica.

Dr. Salman Ahmed

Analgesic activity on two Cleome scaposa and Cleome brachycarpa by applying pressure-induced pain model

Dr. Salman Ahmed