Phosphate type kidney stone (brushite) formation in gel: a morphological study on growth patterns to evaluate natural antiurolithiatic drugs

Brushites are the most commonly found phosphate stones in the kidneys, ureters and urinary bladder. The study was conducted to observe the possible growth patterns of brushite crystals in the gel for 14 days. The crystal formation was observed as a bullet, needle, platy, columnar shaped and their aggregates. Magono and Lee's meteorological classification further explained these shapes. Besides the morphology, the average size, number and weight of crystals were also observed on the 7th and 14th days. Energy Dispersive X-ray, Fourier Transform Infra Red spectroscopy and Scanning Electron Microscopy were used to characterize the crystals. These results can help to determine the promotion, modulation and inhibition of the crystals, which will be helpful in evaluating the risk factors and prophylactic management of brushite-type urinary stones.

Dr. Salman Ahmed Dr. salman ahmed

Near infrared spectroscopy of cicer arietinum l., seeds

NIRS is an advanced, fast, reliable, and non-destructive technique that is extensively used in the chemical, food, petrochemical, and pharmaceutical industries for rapid and reliable standardization. NIRS of Cicer arietinum L. Desi and Kabuli variety seed flours were performed to evaluate secondary metabolites qualitatively. The principal suggested compounds in Cicer arietinum Desi and Kabuli variety were found as adenine, biochanin-A, biochanin-B, biochanin A 7-O- β -D-glucoside, calycosin, cerebroside, choline, ciceritol, citric acid, daidzein, fructose, garbanzol, genistein, glucose, inositol, isoliquiritigen, liquiritigenin, methyl tetracosanoate, ononin, pyrimidine, saccharose, sissotrin, stigmasterol, trifolirhizin. β- amyrin and β-sitosterol. These compounds' presence justifies using Cicer arietinum as a nutritional food and tonic.

Dr. Salman Ahmed Dr. salman ahmed

Usage de l’alternance codique chez l’enseignant d’espagnol au premier cycle

Cet article s’intéresse à la fréquence, aux fonctions de l’alternance codique chez l’enseignant d’espagnol en classe de quatrième (débutants) et aux activités pédagogiques au cours desquelles apparaît ce phénomène de contact de langue. Notre investigation porte sur 80 enseignants d’espagnol et 1000 élèves hispanophones de la région de San Pedro en Côte d’Ivoire. Pour ce faire, nous avons opté pour l’analyse quantitative et qualitative. La première méthode par le biais du logiciel SPSS a permis de constituer une base de données. Ainsi, il ressort que 51 soit 63,1% des enseignants utilisent 5 à 10 % du temps du cours pour s’exprimer en français. Aussi, ces enseignants alternent-ils plus ces deux langues pendant les activités de compréhensions de texte, et vocabulaire soit 32,1% de l’effectif. Quant à l’analyse qualitative de type conversationnel, elle a servi à proposer quelques fonctions d’alternance codiques pendant les activités d’interaction.

Assanvo

A pervasive multi-distribution perceptron and hidden markov model for context aware systems

Fueled by the recent advancements in pervasive environment, affluent context aware systems is among the rousing in computing today, including embedded environment, different wireless network technology, electronic communication and so on. Context-Aware Collaborative Filtering using Genetic Algorithm approach resulted in an improved mobile business model by determining optimal similarities between contexts. In this work, we plan to devise a hybrid framework called Multi-distribution Perceptron and Hidden Markov Model to smoothen the mobile networks with different degrees of context- confidence. Initially, Multi-distribution Layer Perceptron Model is designed aiming at improving the precision rate with the aid of Multi-distribution Bayesian Posterior measure. Experimental analysis shows that the M-PHMM framework is able to reduce the computational complexity for obtaining user patterns by 26.05% and improve the precision rate by 18.90% compared to the state-of-the- art works.

Dr H Shaheen Dr h shaheen

The effects of severe hypobaric hypoxia and inhibition of hypoxia-inducible factor-1 (hif-1) on biomarkers of cardiac and skeletal muscle injury in rats

The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated that the level of the cardiac bio-marker troponin I in the blood plasma of rats exposed to severe hypobaric hypoxia for 3 h increased signifi-cantly compared to the control group, indicating myocardial injury. At the same time, the administration ofthe HIF-1α transcription factor inhibitor did not affect the plasma level of troponin I. In contrast, the releaseof the non-specific biomarker myoglobin into the bloodstream did not increase in response to hypoxia com-pared to the control animals. In addition, 24 h after the exposure to severe hypobaric hypoxia the serum myo-globin level was significantly lower in animals administered with the HIF-1α inhibitor topotecan than in ratsthat did not receive topotecan. Therefore, it may be assumed that the inhibition of the HIF-1α transcriptionfactor 10 min before exposure to severe hypobaric hypoxia reduces skeletal muscle damage. The mechanismsthat affect the adaptation of heart and skeletal muscles to hypoxia are discussed.

Даниил Федоров Даниил Федоров

Common errors in writing of prescriptions in benghazi

Good prescription writing is essential for dispensing the right drug formulation and dose. When prescriptions are not legible, inaccurate and do not include complete information, there is a possibility of prescribing errors occurring, which leads to adverse events. Poor handwriting is another important issue that makes the information unclear; especially look-alike drug names that may be confused by the pharmacist. World Health Organization has issued a practical manual for Good Prescribing that includes the essential information that should be included in a prescription. In this study, we attempt to investigate the problem of bad prescribing habits in out-patient prescriptions in Benghazi, Libya. Two hundred seventy-five out-patient prescriptions were collected from two private pharmacies on four consecutive days. These prescriptions were scanned for any errors or missing information depending on the standard criteria established by World Health Organization in its practical manual "Guide to Good prescribing". The collected data were processed and statistically analyzed by using SSPSS to calculate the percentage of missing information. Eleven percent (11.0%) of the prescriptions had no address or name of the prescriber on them while 58.0% had no date written on them and in 21.0% the prescriber did not sign the prescription. The age of the patient was only written on 38.0% of the prescriptions. The name of the medication was not clearly written in 18.0% of the prescriptions, while the dosage form of the medication was not written at all in 18.0% and not clearly written in 20.0% of the prescriptions. The total amount of the prescribed drug was not written in 30.0% of the prescriptions. It is to conclude that prescribers included in this study wrote prescriptions with a lot of missing and unclear information as per WHO guidelines for a good prescribing. This shows the weak attitude of Libyan prescribers toward the different aspects of “Good Prescribing”.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Anti-emetic activity of six aromatic medicinal plants by using chick emetic model

The current study explored the anti-emetic activity of six aromatic medicinal plants viz Carissa carandus L.. Cichorium intybus Cinnamomum tamala L.. Lallemantia royleana Benth. Matricaria chamomilla L., and Piper metysticum G. Forst . Anti-emetic activity was assessed using a chick as an anti-emetic model. The ethanol extracts of these plants were administered at 150 mg/kg BW orally. Lallemantia royleana and Piper metysticum showed a significant (P <0.001 ) decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg/kg BW. Domperidone was given at 100 mg/kg as a reference drug.

Dr. Salman Ahmed Dr. salman ahmed

Pengembangan bakat dan minat peserta didik di madrasah ibtidaiyah miftahul muna kesilir banyuwangi

Each student has different potentials from one another, because each person is indeed born with a variety of different talents and has brought out his or her own nature, namely good nature that encourages tawhid and other natural qualities in the form of various innate potentials such as talents, intellectual abilities and others. The research approach used is a descriptive qualitative approach with the type of case study. The techniques used are interviews, observation, and documentation. While the validity of the data used triangulation of techniques and sources. The results of this study indicate: (1) Mina talents at MI Miftahul Muna through recruitment where students choose and register themselves to take part in the extracurricular program. Such as: drumband, dance, qiroat, scout, Pencak Silat, Chess, Volleyball, football, hadrah, singing, fashion, culinary, and calligraphy. (2) Interest talent planning, namely: Learning Implementation Plan, preparing experts who are competent in their fields as well as students recruited through extracurricular registration. Except for the drum band in this case bringing in experts from outside. (3) Implementation of talent and interest development at Madrasah Ibtidaiyah Miftahul Muna Kesilir, which is carried out once a week every Friday unless the drumband is held on Fridays and Sundays and if you want to appear at certain events, you can adjust the trainer's schedule or not. (4) Supervision is carried out directly at the time of the activity and some is carried out in an indirect way such as in this drumband activity because it brings in a trainer and is reported to the Madrasah Head.

EDUCARE: Journal of Primary Education Educare: journal of primary education

The effects of aggressive-pornographic mass media stimuli

This chapter discusses the effects of stimuli that combine sexuality and aggression. It outlines the debate over aggressive versus nonaggressive pornography and discusses the frequency of aggressive pornography and bases for concern. Aggressive pornography and sexual arousal is explored in the chapter wherein initial findings, victim's responses, individual differences, context of assessment, and conclusions are discussed. The chapter reviews the effects of aggressive pornography on responses other than aggression wherein it has discussed about changes in sexual responsiveness, fantasies, and perceptions and attitudes. The effects of aggressive pornography on aggression are explored in the chapter wherein research findings are discussed in detail and summary of effects on aggression, theoretical analyses, and the construct validity of assessing aggression are also described. The data across the laboratory and field experiments discussed in this chapter raise a variety of theoretical and empirical issues that should be addressed in future research. Particularly noteworthy are questions concerning stimuli, subject, and setting characteristics.

John Dolores John dolores

A brief review cisplatin: a drug for the treatment of cancer

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It is one of the most widely used chemotherapeutic agents for various solid tumors in the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin is mainly due to its ability to cross-link with DNA, thus blocking transcription and replication, Subsequently inducing apoptosis in cancer cells. However, because of drug resistance and numerous undesirable side effects such as severe kidney problems, allergic reactions, decreased immunity to infections, gastrointestinal disorders, hemorrhage, and hearing loss especially in younger patients. Other common side effects include ototoxicity, neurotoxicity, gastrointestinal toxicity, hematological toxicity, cardiotoxicity, and hepatotoxicity. These side effects together reduce the life quality of patients and require lowering the dosage of the drug, even stopping administration, thus weakening the treatment effect Therefore, substantial effort has been made to explore the complicated biochemical processes involved in the toxicology of cisplatin, aiming to identify effective ways to reduce or eradicate its toxicity. This review summarizes and reviews the updated advances in the toxicological research of cisplatin.

Nehal Nehal

Using a resnet50 with a kernel attention mechanism for rice disease diagnosis

The domestication of animals and cultivation of crops have been essential to human development throughout history, with the agricultural sector playing a pivotal role. Insufficient nutrition often leads to plant diseases, such as those affecting rice crops, resulting in yield losses of 20-40% of total production. These losses carry significant global economic consequences. Timely disease diagnosis is critical for implementing effective treatments and mitigating financial losses. However, despite technological advancements, rice disease diagnosis primarily depends on manual methods. In this study, we present a novel Self-Attention Network (SANET) based on the ResNet50 architecture, incorporating a kernel attention mechanism for accurate AI-assisted rice disease classification. We employ attention modules to extract contextual dependencies within images, focusing on essential features for disease identification. Using a publicly available rice disease dataset comprising four classes (three disease types and healthy leaves), we conducted cross-validated classification experiments to evaluate our proposed model. The results reveal that the attention-based mechanism effectively guides the Convolutional Neural Network (CNN) in learning valuable features, resulting in accurate image classification and reduced performance variation compared to state-of-the-art methods. Our SANET model achieved a test set accuracy of 98.71%, surpassing current leading models. These findings highlight the potential for widespread AI adoption in agricultural disease diagnosis and management, ultimately enhancing efficiency and effectiveness within the sector.

Mehdhar S. A. M. Al-Gaashani Mehdhar s. a. m. al-gaashani

Kink and periodic solutions to the jimbo-miwa equation and the calogero-bogoyavlenskii-schiff equation

In this article, we form the exact wave solutions of the Jimbo-Miwa equation and the Calogero-Bogoyavlenskii-Schiff equation by applying the new generalized (G'/G)-expansion method. We explained the new generalized (G'/G)-expansion method to look for more general traveling wave solutions of the above mentioned equations. The traveling wave solutions attained by this method are in terms of hyperbolic, trigonometric and rational functions. The graphical representation of the obtained solutions is kink soliton, singular kink soliton, singular soliton and singular periodic solution. This method is very significant for extracting exact solutions of NLEEs which habitually occur in mathematical physics, engineering sciences and applied mathematics.

Md khorshed alam

Analysis of the effect of communication, competence and work discipline on job satisfaction at pt tribahtera srikandi

This study aims to determine the effect of communication, competence and work discipline on job satisfaction at PT. Tribahtera Srikandi. This research was conducted at PT. Tribahtera Srikandi lasted for 6 months, starting from January 2020 to June 2020. Sampling was taken in research using proportional random sampling method. The population in this study are all employees of factory workers in PT. Tribahtera Srikandi 155 people. The number of respondents in this study was established by using the statistics of the population, amounting to 112 people. The instruments used to collect data are questionnaires from communication, competence, work discipline and job satisfaction. The data analysis tool in this study is a multiple linear regression by carrying out a classic assumption test that is continued by testing the partial hypothesis or t test, the simultaneous hypothesis test or the F test, and the calculation of the coefficient of determination. The contribution of communication, competence and work discipline variables explained the variable of job satisfaction as big as 0.765 or 76.5%. The remaining 0.235 or 23.5% was influenced by other independent variables not examined in this study.

Lila Maria Kaban Lila maria kaban

A collective review of the synthetic approaches disclosed in prior patents to synthesize the renowned drug, lamotrigine

In this review work, we have extracted the essential details from prior patents about the synthesis of popular drug Lamotrigine. This initiative will provide a platform for the global researchers to invent new or innovate over the existing synthetic routes to isolate Lamotrigine with good yield and purity. The details of patents were sourced from “Google patents” search tool and the process specific details were elaborated with reaction schemes. In this context, twenty-four reactions schemes were tabulated for the better understanding of the disclosed ventures. The entire chronological exfoliation of details on the synthesis of Lamotrigine provides a clear evolutional vision of its synthetic flourish towards drug commercialization.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Incidence of agranulocytosis adverse effect of antipsychotic drugs in patients with schizophrenia

Schizophrenia is treated with antipsychotic drugs and is a chronic neuropsychiatric disorders. The influence of antipsychotics on the cytokine systems may be responsible for their clinical efficacy in schizophrenia. Granulocytopenia and agranulocytosis are severe side effects of antipsychotic therapy. The objective of this study was to estimate incidence of drug-associated agranulocytosis in newly diagnosed schizophrenic patients in and to evaluate the risk factors and outcomes. Seven participants groups were designed. Healthy persons as control. Schizophrenic patients before treatment. Schizophrenic patients after one-month of treatment. Schizophrenic patients after two - month of treatment. Schizophrenic patients after three - month of treatment. Schizophrenic patients after chronic treatments. Schizophrenic patients one month after chronic treatment. This study included screening for the expression and function of circulating leukocyte granulocyte-macrophage colony-stimulating factor receptor, screening of patient's biochemistry and haematology picture. Granulocyte-macrophage colony-stimulating factor expression was decreased after antipsychotic treatment for one month and continued to decrease after two months' treatment. Granulocyte-macrophage colony-stimulating factor expression starts to increase after the two-month treatment and continues increasing to controls or newly diagnosed schizophrenics or after chronic treatment. Complete blood counts were not changed compared. Liver function showed a transient increase in serum alkaline phosphatase after one and two month of treatment. All other parameters were not changed. Kidney function showed that urea and creatinine levels were within the normal range during the different treatments. Concerning lipid profile, low density lipoproteins levels were increased after one month, two months of treatment and after chronic administration of the antipsychotic drugs. It is concluded that antipsychotic treatment produces a decrease in granulocyte-macrophage colony-stimulating factor expression; the decrease reach the maximum effect after two months, then starts to increase back to normal levels. A transient increase in serum alkaline phosphatase in the first two months' treatment. Urea and creatinine levels and lipid profile were within normal range, except low density lipoproteins levels were increased during the two months treatment and after chronic administration of the antipsychotic drugs.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Fdi in indian higher education

The decision of the government of India to allow foreign direct investment in higher education is based on a consultation paper prepared by the commerce ministry, which is marked by arguments, perverse logic and forced conclusions. FDI in any field does not have an attached objective of fulfilling social agenda of the welfare state. It is guided by profit and market. This would result in commoditization of education. As per past most foreign institutes invest in technical courses which market needs rather than in quality education and research which is important for creating and developing human resource. There is a shortage of funds in higher education sector. Here are not many ways in which this investment in this sector can be increased in this sector domestically. Since a large number of students go abroad for their higher education, it is sensible to allow foreign universities to set up their campuses here, in India. This would help in arresting the outflow of monetary and human capital. Further, foreign higher educational institutes would create competition with the local institutes making them internationally competitive this article examines the issues and financial compulsions, presented in the consultation paper

Dr Gedam Kamalakar Dr gedam kamalakar

Rice bean (vigna umbellata) the forgotten gold: unraveling the commercial, nutritional and medicinal value

Rice bean (Vigna Umbellata), a traditional crop cultivated across South, Southeast, and East Asia, is characterized by its wild variety spanning the tropical monsoon forest climatic zone. Despite its vast nutritional and production potential, falling within the leguminous family Fabaceae, the rice bean represents one of many underutilized crops. Indigenous to South and Southeast Asian regions, particularly hilly areas, rice bean is cultivated alongside crops like maize, forming an integral part of impoverished farming communities' livelihoods. Despite its extensive utilization in traditional practices, its commercial significance remains largely unrecognized. However, recent attention has been drawn to the rice bean's nutritional richness, bioactive compounds, and various medicinal properties, including anti-inflammatory, antioxidant, and antidiabetic effects. This significant attention underscores its potential for commercialization and contribution to improving the livelihoods of underprivileged populations. Furthermore, its cultivation and processing give rise to diverse products, reflecting its cultural significance and adaptability across different regions.

Dr. Salman Ahmed Dr. salman ahmed

Screening of salt tolerant and growth promotion efficacy of phosphate solubilizing bacteria.

An attempt was made for screening of salt tolerant against sodium chloride (NaCl) salt and growth promotion efficacy of eight different phosphate solubilizing bacterial (PSB) isolates under in vitro conditions. An efficient isolate which exhibited maximum phosphate solubilization, salt tolerant, Indole-3-Acetic Acid (IAA) production and root colonization potential in maximum concentration of NaCl (7%) was identified as Bacillus cereus based on 16S rRNA sequencing. It was recorded that highest phosphate solubilization in 7% NaCl concentration (70% and 374 μg/mL) in agar plate and broth assay respectively. IAA production was observed to be decreased when salt concentration increases, the isolate showed significant amount of IAA in normal culture media without amendment of NaCl (74.94 μg/mL) and at 7% gradual decrease of IAA production was observed (30 μg/mL). Maximum colonization of isolate in the roots of Zea mays was also observed in the study.

Dr. SARANYA DEVI K Dr. saranya devi k

Human resource management - mind map on traditional functions of hrm

Human resource management refers to the process of employing people, training them, compensating, and developing policies and strategies to keep them (Storey, 2016). Personnel management is an administrative specialisation that focuses on hiring and developing employees to become valuable to the organisation (Bondarouk, Trullen, and Valverde, 2016). Management of personnel can be characterised as a satisfied workforce being achieved, used, and maintained (Sheehan, Garavan & Carbery, 2014). It constitutes an essential aspect of the management of employees in the organisation and their connection. According to Schroeder (2012, p.4), personnel management is achieved to help organisational, individual, and social goals, as the planning, organisation, offsetting, and maintaining of people. Vargas et al. (2018, p. 3052) add that personnel management is the element that primarily deals with human organisational resources. Management of personnel covers job, development, and compensation functions. In consultation with other departments, the personnel management performs these functions principally (Vargas et al., 2018, p. 3053)

Zamzam Abdelazim Zamzam abdelazim

Stress among banking employee- a literature review

For banking employees around the globe, stress on the job can be a challenge; stress can be sometimes positive and sometimes negative. Positive stress leads to productivity and negative stress leads to loss for the organization. There is already a certain level of stress in Banking employees work life and then encounter even more stress arising from the work pressure that Banking employees face on the job. Many employees cannot cope with such rapid changes taking place in the jobs. Role conflict, Service for customer, contribution, rapid technological change, lack of customer response is the great transaction of stress for the banking workers. The aim of this research is to understand roots and outcomes of job stress on the employee performance in banking sector.

Dr MANJUNATHA M K Dr manjunatha m k

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