Dr. Salman Ahmed
Therapeutic potential of naringin in neurological disorders
Journal title : Food and Chemical Toxicology
Publisher : Elsevier BV
Print ISSN : 0278-6915
Page Number : 110646
Journal volume : 132
290 Views Reviews Article
Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative medicine for treating neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin, and naringin (NRG), have been shown to possess promising potential in treating neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.
Article DOI & Crossmark Data
DOI : https://doi.org/10.1016/j.fct.2019.110646
Article Subject Details
Article Keywords Details
Article File
Full Text PDFArticle References
- (1). 10.1016/j.lfs.2010.04.011
- (2). 10.3389/fnmol.2015.00035
- (3). 10.1016/j.febslet.2011.07.046
- (4). 10.1007/s13105-011-0142-y
- (5). 10.1007/s13277-015-4230-4
- (6). 10.1002/cber.19280610713
- (7). 10.1007/s11064-014-1326-y
- (8). 10.1016/j.biopha.2018.10.055
- (9). 10.1055/a-0575-3730
- (10). 10.1161/STROKEAHA.108.527705
- (11). 10.1055/s-0034-1368351
- (12). 10.1155/2017/6031478
- (13). 10.1007/s00394-010-0117-8
- (14). 10.1016/j.fitote.2013.11.003
- (15). 10.1155/2018/4067597
- (16). 10.1016/j.fct.2018.08.028
- (17). 10.1007/s12035-018-1027-7
- (18). 10.1016/S0944-7113(98)80018-4
- (19). 10.1016/j.ejphar.2009.06.056
- (20). 10.1371/journal.pone.0012399
- (21). 10.1016/j.yebeh.2014.09.058
- (22). 10.1002/dvdy.20512
- (23). 10.1016/j.neuroscience.2012.07.060
- (24). 10.1139/cjpp-2015-0035
- (25). 10.1007/s10571-012-9827-1
- (26). 10.1016/j.brainresbull.2016.12.008
- (27). 10.1021/jf035079g
- (28). 10.1159/000076349
- (29). 10.3892/br.2014.267
- (30). 10.5607/en.2014.23.2.124
- (31). 10.3109/03639040903140589
- (32). 10.1016/j.fitote.2012.01.010
- (33). 10.1007/s12253-013-9702-5
- (34). 10.3736/jcim20121223
- (35). 10.1055/s-2004-815449
- (36). 10.3109/10717544.2013.878003
- (37). 10.3109/03639045.2014.902466
- (38). 10.1016/j.autrev.2019.05.001
- (39). 10.1016/j.coph.2011.10.007
- (40). 10.4196/kjpp.2009.13.4.281
- (41). 10.1089/jmf.2016.3712
- (42). 10.4103/1673-5374.213694
- (43). 10.1016/j.yebeh.2018.10.006
- (44). 10.1016/j.yebeh.2017.07.011
- (45). 10.1128/MCB.01428-09
- (46). 10.1007/s11010-015-2525-9
- (47). 10.1089/jmf.2009.1251
- (48). 10.1016/j.fct.2009.11.043
- (49). 10.1016/j.bbr.2009.08.028
- (50). 10.1016/j.compbiomed.2018.05.012
- (51). 10.1007/s10570-013-9970-y
- (52). 10.1007/s11064-018-2488-9
- (53). 10.1016/j.bbrc.2014.08.117
- (54). 10.1080/1061186X.2016.1184668
- (55). 10.1016/j.neuropharm.2013.11.026
- (56). 10.1002/path.4449
- (57). 10.1016/j.bbrc.2015.10.152
- (58). 10.1211/jpp.58.9.0009
- (59). 10.1016/j.bcp.2004.09.018
- (60). 10.1016/j.canlet.2018.07.018
- (61). 10.1016/j.phrs.2017.10.008
- (62). 10.3390/antiox7080109
- (63). 10.1080/09168451.2018.1456320
- (64). 10.1016/j.jep.2008.02.015
- (65). 10.1016/j.fct.2008.09.056
- (66). 10.3109/00207454.2013.785542
- (67). 10.1016/j.abb.2011.11.026
- (68). 10.1016/j.brainresbull.2016.04.020
- (69). 10.1016/j.neuroscience.2012.09.026
- (70). 10.1016/j.tox.2007.01.006
- (71). 10.1016/j.biopha.2017.08.028
- (72). 10.1016/j.biopha.2016.10.080
- (73). 10.1016/j.fct.2012.07.033
- (74). 10.2174/1381612822666160530150936
- (75). 10.1371/journal.pone.0082577
- (76). 10.1016/j.neuroscience.2012.10.041
- (77). 10.1016/j.pharmthera.2018.09.009
- (78). 10.4103/1673-5374.202923
- (79). 10.1007/s11064-012-0756-7
- (80). 10.1016/j.pbb.2014.11.002
- (81). 10.1016/j.brainres.2012.08.036
- (82). 10.1093/jn/136.6.1477
- (83). 10.3892/mmr.2014.1940
- (84). 10.1371/journal.pone.0018033
- (85). 10.1159/000453580
- (86). 10.1021/acs.jafc.8b02696
- (87). 10.1016/j.bcp.2013.03.018
- (88). 10.18632/oncotarget.25175
- (89). 10.1016/j.biopha.2017.07.072
- (90). 10.3736/jcim20111115
- (91). 10.1039/C4RA04920A
- (92). 10.1208/s12249-016-0537-8
- (93). 10.1016/j.pbb.2012.03.013
- (94). 10.1007/s10571-015-0201-y
- (95). 10.3892/ijmm.2017.2904
- (96). 10.1016/j.cbi.2015.10.010
- (97). 10.1142/S0192415X07005156
- (98). 10.1002/jor.20279
- (99). 10.1007/s12035-014-9042-9
- (100). 10.12659/MSM.902396
- (101). 10.1248/bpb.b12-00451
- (102). 10.1016/j.carbpol.2013.07.010
- (103). 10.1007/s10072-013-1594-3
- (104). 10.3389/fnagi.2018.00169
- (105). 10.1007/s11095-008-9791-0
- (106). 10.1016/j.cbi.2015.04.003
- (107). 10.1016/j.pnpbp.2010.06.024
- (108). 10.1016/j.pnpbp.2012.06.009
- (109). 10.1016/j.pnpbp.2013.10.002
- (110). 10.1016/j.bmcl.2012.10.130
- (111). 10.1007/s10753-014-0022-z
- (112). 10.1080/10715760500233113
- (113). 10.1021/je501004g
More Article by Dr. Salman Ahmed
The seeds of cleome viscosa are used in traditional systems of medicine for the treatment of many diseases in asia. this study evaluated fixed oil from the seeds of cleome viscosa...
Plants have been used as medicine for the treatment of diseases for thousands of years. these herbal remedies, although natural, can cause some serious damaging effects on the vita...
The current study was conducted to explore the antiemetic activity of ten aromatic medicinal plants viz., carissa carandus l. (fruits), chichorium intybus l (flowers), cinnamum tam...
Crude methanol extracts of the leaves of adenanthera pavonina l., peltoforum roxburghii l, prosopis cineraria l., and prosopis juliflora dc., were evaluated for anti-emetic activit...