Dr. Salman Ahmed
The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation
Journal title : Biomedicine & Pharmacotherapy
Publisher : Elsevier BV
Print ISSN : 0753-3322
Page Number : 1292-1299
Journal volume : 106
301 Views Reviews Article
About 12% of the world's population is affected by different forms of urolithiasis, of which the recurrence rate in females is 47–60% and in males is 70–80%. Standard therapeutic agents (allopurinol, citrate, cystone and thiazide diuretics) prevent and treat urolithiasis. Still, these are not universally-effective due to common kidney stone relapse and other side effects. Surgical treatment causes long-term renal damage, hypertension and stone recurrence. Polyphenols, the plant-derived bioactive molecules, have showed protection against cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases, among several other ailments. The role of these phytochemicals in urolithiasis management is emerging. Hence, the present review discusses peer-reviewed published literature to date on this aspect and highlights that polyphenols could effectively inhibit the formation of calcium oxalate urinary stones (most common renal stone), correlating with their antioxidant, anti-inflammatory, diuretic and angiotensin-converting enzyme (ACE) inhibition. Further, we have proposed the prospects and challenges in developing plant polyphenols into drugs against kidney stone prevention. This review might be a stepping stone for further investigation into the clinical implications of polyphenols in urolithiasis remediation.
Article DOI & Crossmark Data
DOI : https://doi.org/10.1016/j.biopha.2018.07.080
Article Subject Details
- Health Science
- Medicine
- Nephrology
- Pharmacognosy
- Pharmacology
- Pharmacy
- Urology Nephrology and Hepatology Science
Article Keywords Details
- Calcium oxalate
- Kidney stone
- Medicinal plants for kidney stone
- Pharmacognosy
- Pharmacology
- Pharmacy
- Polyphenols
Article File
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