Arafat Hassan Razon
The intricate mechanisms of functional foods oyster mushroom and fenugreek on type 2 diabetic animal model
9 Views Original Article
Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)–activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells. Diabetic model rats were administered standard diets supplemented with 5% oyster mushroom powder (mushroom-treated (MT) group) and 5% fenugreek seed powder (fenugreektreated (FT) group) for 8 weeks. The results showed improvements in both glycemic and lipid profiles, with both oyster mushroom and fenugreek enhancing the phosphorylation of AMPK in muscle tissue. However, no effect on insulin secretion was observed. These findings suggest that both substances reduce hyperglycemia through an insulin-independent pathway. In silico analysis of both mushroom and fenugreek seed extracts revealed bioactive compounds having a strong binding affinity to α-glucosidase, which suggests mushroom and fenugreek supplements might control postprandial blood glucose levels.
Article DOI & Crossmark Data
DOI : https://doi.org/10.1155/jdr/6209785
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Arafat Hassan Razon
Dietary intake of contaminated food with heavy metals may cause severe risk for the human health. heavy metals affect adversely a human health. the current study assessed the conce...
Background: as bangladesh has gained the reputation of improving the health sectors, much health related sites still require improvements. community clinic services (ccs) may contr...
Context: menstruation is one of the most basic characteristic features of girls and inadequate knowledge of adolescent girls about menstruation can result in faulty menstrual hygi...
Background: old age is one of the vulnerable and prone stages in terms of health status. so this study aimed to assess the nutritional status and common health complications of old...