Dr. Salman Ahmed

The effect of phaseolus vulgaris l. fixed oil on the behavioural activity of swiss albino mice

• Authors Details :  
• Salma,  
• Sadia Ghousia Baig,  
• Muhammad Mohtasheem Ul Hasan,  
• Salman Ahmed,  
• Syeda Anum Fatima

140 Views Original Article

Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Article Subject Details

• Health Science
• Medicine
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy
• Pharmacy practice

Article Keywords Details

• Behavioural activity
• Fixed oil
• Phaseolus vulgaris
• Swiss Albino mice

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