Mediterranean Journal Of Pharmacy And Pharmaceutical Sciences

Sedative-hypnotic effects of datura arborea linn extract in experimental animals

• Authors Details :  
• Aisha Idris

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Datura arborea Linn is a sacred plant known for over 3000 years to have been used for magical and curative purposes. It was shown to have a central nervous system depressant effect. The active substances identified were tropane alkaloids: atropine, scopolamine, and hyosine. Therefore, we aimed to find out whether the ethanol extract of Datura arborea Linn has sedative and hypnotic activity. The extract was subjected to a thiopental sodium-induced sleep test and diazepam was used as a standard drug. The plant possesses sedative-hypnotic qualities, the findings indicate that doses of 35 mg/kg (2.70.24 min), 70 mg/kg (3.80.19 min), and 140 mg/kg (4.30.20 min) decreased the control's (9.2 min) latency to fall asleep. In comparison to the control, the length of sleep was increased by 23.46 minutes for 35 mg/kg (99.002.99 min), 70 mg/kg (132.605.53 min), and 140 mg/kg (118.606.04 min), respectively. The present study established the acute toxicity of Datura arborea Linn to be less than 600 mg/kg in mice. This study indicated that the ethanol extract of Datura arborea Linn has a sedative-hypnotic activity in the diazepam-induced sleep test. It is safe to suggest that the extract acts via either β-receptor by causing hyperpolarization or a decrease in spike activity in the cell, leading to relaxation, but these effects were not blocked by β-antagonist or α2-receptor to decrease acetylcholine release, leading to relaxation of the smooth muscle.

Article Subject Details

• Pharmaceutical sciences
• Pharmacognosy
• Pharmacology
• Pharmacy

Article Keywords Details

• Datura arborea L.
• sedative-hypnotic action
• sleep
• CNS depression

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