Dr. Wahul Umesh B
"potential antidiabetic activity of m. charantia linn. extract on alloxan induced albino wistar rats in diabetes mellitus: an in vivo approach".
232 Views Original Article
The study of diabetes is not only limited to particular symptoms, but it is consequently affects the pathological and functional changes in the metabolic pathways of human body system. In those symptomatic diseases various drugs are used to treat the diabetes such as biosimilar therapy including use of insulin and insulin analogues, oral hypoglycaemic agents and various other complementary medicines. In understanding of suggested potential antidiabetic, effect of M. charaantia Linn. on fasting blood sugar levels and its biochemical analysis in alloxan- induced diabetic rats were investigated. The extracts of M. charaantia Linn. Produced a significant antidiabetic activity at normal dose levels of their lethal doses. A comparison between the action of reduction in blood glucose level in different dose forms of M. charantia extract and Std. drug were seen. An oral glucose tolerance or oral tolerance test were performed with the use of glucose strip Accu-check meter. The different extract viz. ethanol extract + water, petroleum ether + Isopropyl alcohol extract were used for further dosing purpose. The ethanol + water extract were showed significant (P<0.001) antidiabetic activity. In alloxan induced rat model blood glucose level were as, 214.5±5 mg/dLfor std.drug and 216.5±5 mg/dL in comparison with diabetic control 225.5±5 mg/dL. An ANOVA was used for the statistical analysis and p-values less than 0.01 compared to normal group and 0.05 compared to diabetic control group were considered statistically significant. The extract of M.charantia Linn. from seed at the dose of 250 mg/kg, significantly shows the better result in reduction of blood glucose level as compared to the concentration of 500 mg/kg. The increased level of glucose due to the damage of pancreas showed regeneration of pancreatic enzymes by extract of M. charaantia Linn. Which were damaged by alloxan treatment. These solvent extract also balance the body weight loss in diabetic rat, hence the present extract shows the potential to act as antidiabetic drug.
Article Subject Details
- Biochemistry
- Biochemistry clinical laboratory
- Biotechnology
- Insulin resistance
- Pharmaceutical biotechnology
- Statistics
Article Keywords Details
Article File
Full Text PDFMore Article by Dr. Wahul Umesh B
“phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. initially the 6 day o...
The screening of perfect diuretics for non-clinical utility in diabetes mellitus is a relatively novel approach which gain inssight into underlying the pathophysiological processes...
As we aware diabetes is not only one kind of symptomatic disease but its occurrence spread through the various metabolic channels and hence raises other disorders. the prolonged sy...
Ros (reactive oxygen species) production via oxidative stress leads to selective neuronal degeneration and finally results in neurodegenerative diseases. pd (parkinson’s disease) i...