Phosphate type kidney stone (brushite) formation in gel: a morphological study on growth patterns to evaluate natural antiurolithiatic drugs

Salman Ahmed; Muhammad Mohtasheemul Hasan; Zafar Alam Mahmood

Dr. Salman Ahmed

Authors Details :
Salman Ahmed,
Muhammad Mohtasheemul Hasan ,
Zafar Alam Mahmood

Journal title : Journal of Pharmaceutical & Scientific Innovation

Publisher : Annals of Medical and Health Science Research

Online ISSN : 2277-4572

Page Number : 64-68

Journal volume : 6

Journal issue : 3

123 Views Original Article

Brushites are the most commonly found phosphate stones in the kidneys, ureters and urinary bladder. The study was conducted to observe the possible growth patterns of brushite crystals in the gel for 14 days. The crystal formation was observed as a bullet, needle, platy, columnar shaped and their aggregates. Magono and Lee's meteorological classification further explained these shapes. Besides the morphology, the average size, number and weight of crystals were also observed on the 7th and 14th days. Energy Dispersive X-ray, Fourier Transform Infra Red spectroscopy and Scanning Electron Microscopy were used to characterize the crystals. These results can help to determine the promotion, modulation and inhibition of the crystals, which will be helpful in evaluating the risk factors and prophylactic management of brushite-type urinary stones.