Eworo Raymond Profile Eworo Raymond

Mycobacterium tuberculosis infection and diabetes mellitus-mycobacterium tuberculosis dual burden in subjects attending infectious diseases hospital calabar, nigeria

  • Authors Details :  
  • Eworo,  
  • Okhormhe,  
  • Ntamu,  
  • Esiere

Journal title : International Journal of Research in Medical Sciences

Publisher : Medip Academy

Print ISSN : 2320-6071

Page Number : 3155

Journal volume : 7

Journal issue : 8


Article Views Original Article

Background: The rising global DM epidemic is driving the problem of TB control. This research determined glycemic control in TB only infected and DM-TB comorbidity and the consequence of the double burden on treatment outcome. Methods: fifty M. TB infected subjects and fifty control subjects were enrolled into the study, all the participants gave consents. FPG and HbA1c were determined by Colorimetry. Data were analyzed using SPSS version 20.0 statistical package, differences between groups and variation among groups were determined by Student’s t-test and ANOVA respectively while the association between variables by Pearson’s correlation. Differences were considered statistically significant at p<0.05. Results: The mean FPG and HbA1c levels of TB subjects were significantly (P<0.05) higher than those of the control. The mean BMI of the TB infected subjects was significantly lower (p=0.001) than that of the controls. The mean age, FPG and HbA1c of TB subjects at the beginning phase of treatment were significantly lower (p<0.05) than those of subjects at the continuation phase of treatment. The mean age, FPG and HbA1c of subjects with DM-M.TB coexistence were significantly (p<0.05) higher than those of the M.TB only infected subjects. BMI of the DM-M.TB comorbidity subjects was lower than that of the M.TB only infected subjects (p=0.109). A significant positive correlation was obtained between HbA1C and FPG in M.tb infected subjects. (r=0.910, p=0.001). A negative correlation obtained between HbA1C and BMI in M.tb infected subjects. (r=0.267, p=0.061). Conclusion: Infection with mycobacterium tuberculosis poses a risk to DM and vice versa, which may adversely affect treatment outcome and control of both diseases. Firm efforts to control DM may likely have a significant valuable effect on TB treatment outcome.

Article DOI & Crossmark Data

DOI : https://doi.org/10.18203/2320-6012.ijrms20193411

Article QR Code

Mycobacterium tuberculosis infection and diabetes mellitus-mycobacterium tuberculosis dual burden in subjects attending infectious diseases hospital calabar, nigeria QR Code

Article Subject Details


Article Keywords Details



Article File

Full Text PDF





More Article by Eworo Raymond

Assessment of serum cotinine, c-reactive protein levels and body mass index in smokers in calabar, nigeria.

Abstract cigarette smoking has been linked to health challenges of global concern. this study determined body mass index (bmi), serum cotinine and c-reactive protein levels of smo...

Nutritional background of low-income pulmonary tuberculosis patients on anti-tuberculosis therapy at infectious disease hospital, calabar, nigeria: a case-control study

Background: poverty and malnutrition are associated with the risk of developing tuberculosis (tb). nutritional reintegration with anti-tb therapy may improve treatment success rate...

Risk of pulmonary-reproductive dysfunctions, inflammation and oxidative dna damage in exposure to polycyclic aromatic hydrocarbon in cigarette smokers

Background: exposure to cigarette smoke has been associated with pulmonary and reproductive dysfunctions; inflammatory response, oxidative stress and oxidative dna damage induced ...