Dr. Salman Ahmed

Mechanics insights of curcumin in myocardial ischemia: where are we standing?

• Authors Details :  
• Salman Ahmed,  
• Haroon Khan,  
• Hamed Mirzaei

Journal title : European Journal of Medicinal Chemistry

Publisher : Elsevier BV

Print ISSN : 0223-5234

Page Number : 111658

Journal volume : 183

132 Views Reviews Article

Cardiovascular disorders are known as one of the leading health problems which are associated with mortality worldwide. Myocardial ischemia (MI) is the improper blood supply to the myocardium, which leads to severe complications to life-threatening problems like AMI, atherosclerosis, hypertension, cardiac hypertrophy, as well as diabetic-associated complications such as diabetic atherosclerosis/cardiomyopathy/hypertension. Despite several efforts, the current therapeutic platforms are unrelated to significant results. Hence, it seems that developing novel therapies is required. Increasing evidence indicates that curcumin (CRC) acts as a cardioprotective agent. Given that CRC and its analogues exert their cardioprotective effects via affecting various cardiovascular disease-related mechanisms (i.e., Inflammation and oxidative stress). Herein, we have highlighted the protective impacts of CRC against MI for the first time. This review might be a stepping stone for further investigation into the clinical implications of the CRC against MI. Furthermore, it highlights a legitimate concern for the scientific community, seeking novel techniques and characteristic dynamic biopharmaceuticals against myocardial ischemia.

Article DOI & Crossmark Data

DOI : https://doi.org/10.1016/j.ejmech.2019.111658

Article Subject Details

• Medicine
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy
• Pharmacy practice

Article Keywords Details

• Bioavailability and safety
• Curcumin
• Myocardial ischemia
• Pharmacognosy
• Pharmacology
• Pharmacy

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