Dr. Wahul Umesh B
In vivo approach: potential diuretic activity of m. charantia linn. on alloxan induced albino wistar rats in diabetes mellitus
Journal title : European Journal of Medicinal Plants
Publisher : Sciencedomain International
Online ISSN : 2231-0894
Page Number : 61-75
295 Views Original Article
The screening of perfect diuretics for non-clinical utility in Diabetes mellitus is a relatively novel approach which gain inssight into underlying the pathophysiological processes. This study is aims to evaluate the diuretic effect of a crude aqueous & alcoholic extract of M.charantia Linn. using Albino Wistar Rat model. In this study, the comparative observation of Diuretic activity with standard and extracted compound were shown that the estimated 24‐hour urine contains the Na+ - 3.82 g, 3.82 g, 3.92 g and K+ - 1.35 g, 1.39 g, 1.48 g wt. for Vehicle control, Standard drug, and Extracted compound respectively. Which possess the favoring result means from the spot urine were 10.7±7.0 g/24 h and 3.9±2.1 g/24 h, respectively. Coefficients were 0.035, 0.022, 0.046 at (d±2SD = 7.07 g, 4.42 g and 8.92 g) for sodium chloride and 0.068, 0.031, 0.046 at (d±2SD =4.92 g, 2.31 g, and 3.34 g) for potassium chloride. The Na+ and K+ results can be deduced by conversion (1 g NaCl=0.4 g Na+, 1 g KCl≈0.5 g K+). The present study guide formulation of non clinical trials with statistical study to further measuring the claimed efficacy of M. charantia as a natural remedy for diabetes mellitus.
Article DOI & Crossmark Data
DOI : https://doi.org/10.9734/ejmp/2020/v31i830259
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Dr. Wahul Umesh B
“phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. initially the 6 day o...
The study of diabetes is not only limited to particular symptoms, but it is consequently affects the pathological and functional changes in the metabolic pathways of human body sys...
As we aware diabetes is not only one kind of symptomatic disease but its occurrence spread through the various metabolic channels and hence raises other disorders. the prolonged sy...
Ros (reactive oxygen species) production via oxidative stress leads to selective neuronal degeneration and finally results in neurodegenerative diseases. pd (parkinson’s disease) i...