Wahul Umesh

“in vivo approach: potential diuretic activity of m. charantia linn. on alloxan induced albino wistar rats in diabetes mellitus”.

• Authors Details :  
• Wahul Umesh

Journal title : European Journal of Medicinal Plants

Publisher : Sciencedomain International

Online ISSN : 2231-0894

Page Number : 61-75

152 Views Original Article

The screening of perfect diuretics for non-clinical utility in Diabetes mellitus is a relatively novel approach which gain inssight into underlying the pathophysiological processes. This study is aims to evaluate the diuretic effect of a crude aqueous & alcoholic extract of M.charantia Linn. using Albino Wistar Rat model. In this study, the comparative observation of Diuretic activity with standard and extracted compound were shown that the estimated 24‐hour urine contains the Na+ - 3.82 g, 3.82 g, 3.92 g and K+ - 1.35 g, 1.39 g, 1.48 g wt. for Vehicle control, Standard drug, and Extracted compound respectively. Which possess the favoring result means from the spot urine were 10.7±7.0 g/24 h and 3.9±2.1 g/24 h, respectively. Coefficients were 0.035, 0.022, 0.046 at (d±2SD = 7.07 g, 4.42 g and 8.92 g) for sodium chloride and 0.068, 0.031, 0.046 at (d±2SD =4.92 g, 2.31 g, and 3.34 g) for potassium chloride. The Na+ and K+ results can be deduced by conversion (1 g NaCl=0.4 g Na+, 1 g KCl≈0.5 g K+). The present study guide formulation of non clinical trials with statistical study to further measuring the claimed efficacy of M. charantia as a natural remedy for diabetes mellitus.

Article DOI & Crossmark Data

DOI : https://doi.org/10.9734/ejmp/2020/v31i830259

Article Subject Details

• Biotechnology
• Pharmaceutical biotechnology

Article Keywords Details

• ANOVA
• Furosemide
• M. charantia Linn.
• Normal saline
• P-values etc.

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