Mediterranean Journal Of Pharmacy And Pharmaceutical Sciences
Chiral screening approach of atorvastatin diastereomers by hplc method
276 Views Short Communication
The current study seeks to develop and validate a high-performance liquid chromatography method for atorvastatin diastereomer separation and analysis. In particular, we wish to identify the many diastereomers in atorvastatin, which can help us to better understand their pharmacological properties and provide significant information for pharmaceutical applications. Atorvastatin was chromatographed on a Chiralcel® OD-RH column and n-hexan-2-propanol (95:05 v/v) as the mobile phase, with an injection volume of 10 µL. The solution was pumped at a continuous flow rate of 1 mL/min, with a detection wavelength of 260 nm. The investigation found two peaks with retention times of 3.23 and 3.85 min, respectively. The resolution, capacity, and selectivity factors obtained were Rs = 1.2, k′1 = 3.50, k′2 = 4.37, and α = 1.24.
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
The current covid-19 is now endemic on everycontinent and becomes the most challenging outbreaks over centuries, thus millions of people have been infected with the novel coronavir...
It is with more sorrow and tremendous sadness we remember the death of our colleague the libyan pharmacist, professor mokhtar ramadan haman, at his home in tripoli, libya after lon...
The 2019 coronavirus (covid-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. molecular docking is a ...
Plants are an ancient source of medicine due to the presence of bioactive molecules of various compounds in their different parts. convolvulus dorycnium plant belongs to the family...