Mediterranean Journal Of Pharmacy And Pharmaceutical Sciences
Chemical characterizations and anti-sickling potential of methanol extract of justicia carnea (flamingo plant)
13 Views Original Article
Justicia carnea, a plant rich in bioactive compounds, has traditionally been used as a haemoglobin booster by herbal practitioners in rural areas of Edo State of Nigeria. In this study, the methanol leaves extract of Justicia carnea was investigated for its antisickling potential in hemoglobin SS (HbSS) in-vitro by sodium metabisulphite assay and characterized by Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). Terpenoids, saponins, glycosides, phenolics, flavonoids and alkaloids were present except tannins. Photomicrograph examinations revealed a reduction of sickle cells with a percentage decrease from 37.50%, and 22.22% down to 3.85% with 100 mg/mL crude extract of Justicia carnea at three durations, respectively. Detected compounds from Gas Chromatography-Mass Spectrometry included hexadecanoic acid methyl ester (Retention time (Rt): 21.46, 05.99%) and 9,12-octadecadienoic acid, methyl ester (Rt: 23.567, 02.59%) while the major constituent was phytol (Rt: 23.741, 67.28%). While kaempferol (Rt: 17.23, 16.72%) was the major component from High-Performance Liquid Chromatography quantification among resveratrol (Rt: 3.7, 13.85%), gallic acid (Rt: 5.88, 3.55%), Justicinol (Rt: 11.85, 01.34%) and phytic acid (Rt 5.06, 01.43 %). These compounds have been cited as physiological agents that reduce inflammation, and oxidative stress and potentially prolong the lifespan of cells across species. The antisickling results from this study corroborate and support the traditional use of the plant in treating patients with sickle cell anemia.
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
The current covid-19 is now endemic on everycontinent and becomes the most challenging outbreaks over centuries, thus millions of people have been infected with the novel coronavir...
It is with more sorrow and tremendous sadness we remember the death of our colleague the libyan pharmacist, professor mokhtar ramadan haman, at his home in tripoli, libya after lon...
The 2019 coronavirus (covid-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. molecular docking is a ...
Plants are an ancient source of medicine due to the presence of bioactive molecules of various compounds in their different parts. convolvulus dorycnium plant belongs to the family...