Dr. Salman Ahmed
Apoptosis induced by luteolin in breast cancer: mechanistic and therapeutic perspectives
Journal title : Phytomedicine
Publisher : Elsevier BV
Print ISSN : 0944-7113
Page Number : 152883
Journal volume : 59
252 Views Reviews Article
Background: Breast cancer is a commonly found malignancy worldwide in women, and effective treatment is regarded as a substantial clinical challenge even in the presence of several options. Extensive literature is available that demonstrates polyphenols, the richly introduced phytopharmaceuticals, as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, and curcumin are reported to have tremendous potential against breast cancer. However, till now, no comprehensive survey has been found about the anticarcinogenic properties of luteolin against breast cancer. Scope and approach: This review targeted the available literature on luteolin in the treatment of breast cancer, its effects in combination with other anticancer drugs, and possible mechanisms. Key findings and conclusion: Lutein's outstanding therapeutic potential in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent but also complemented by its synergistic effects with other anti-cancer therapies such as cyclophosphamide, doxorubicin, and NSAIDs such as celecoxib and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.
Article DOI & Crossmark Data
DOI : https://doi.org/10.1016/j.phymed.2019.152883
Article Subject Details
- Breast cancer
- Breast pathology
- Clinical trials
- Oncology
- Pharmacognosy
- Pharmacology
- Pharmacology and toxicology
Article Keywords Details
Article File
Full Text PDFArticle References
- (1). 10.1038/nrc2657
- (2). 10.3390/nu8090581
- (3). 10.1038/srep30917
- (4). 10.2174/1573407212666160314195845
- (5). 10.1016/j.ejphar.2010.10.063
- (6). 10.1016/j.jep.2018.05.019
- (7). 10.1038/srep31450
- (8). 10.1097/CJI.0000000000000073
- (9). 10.1016/j.pharep.2017.05.010
- (10). 10.1002/ijc.27711
- (11). 10.1021/jf0112973
- (12). 10.1158/1535-7163.MCT-11-0963
- (13). 10.1016/j.jfda.2018.01.012
- (14). 10.1021/jf062088r
- (15). 10.1158/1535-7163.MCT-07-0107
- (16). 10.1016/j.tifs.2014.05.003
- (17). 10.1021/jf501548g
- (18). 10.7150/ijbs.20052
- (19). 10.3892/br.2016.747
- (20). 10.1002/ijc.29210
- (21). 10.1056/NEJMra1001389
- (22). 10.2174/138955710791384081
- (23). 10.1016/j.ejpb.2017.04.015
- (24). 10.4161/cbt.2.6.678
- (25). 10.1007/BF02977772
- (26). 10.1016/j.phrs.2017.09.009
- (27). 10.1016/j.redox.2018.01.015
- (28). 10.3389/fphar.2018.00220
- (29). 10.1016/S0092-8674(04)00302-2
- (30). 10.18632/oncotarget.15333
- (31). 10.3329/bjp.v12i4.33182
- (32). 10.3892/or.2012.2158
- (33). 10.1007/s13277-015-3322-5
- (34). 10.1038/cdd.2017.186
- (35). 10.1093/ndt/gfq528
- (36). 10.1371/journal.pone.0000596
- (37). 10.1016/j.biopha.2016.05.042
- (38). 10.1016/j.jff.2017.01.022
- (39). 10.2174/1570193X14666161201124705
- (40). 10.1016/j.lfs.2018.01.013
- (41). 10.1016/j.biopha.2018.03.007
- (42). 10.1016/j.ejmech.2017.10.065
- (43). 10.2174/1573394712666160617081638
- (44). 10.1177/1010428317698365
- (45). 10.15430/JCP.2015.20.4.223
- (46). 10.1016/S0002-9343(01)00995-0
- (47). 10.1016/j.exger.2017.05.014
- (48). 10.1016/j.jsbmb.2017.04.011
- (49). 10.1016/j.canlet.2017.02.012
- (50). 10.1146/annurev-cancerbio-050216-121933
- (51). 10.1016/j.jff.2015.09.030
- (52). 10.1186/s12885-015-1965-7
- (53). 10.2174/156800908786241050
- (54). 10.1016/j.fct.2018.02.003
- (55). 10.1093/jn/134.12.3479S
- (56). 10.1016/j.biopha.2018.07.094
- (57). 10.2174/138955709787001712
- (58). 10.3390/antiox6040088
- (59). 10.1002/jcb.24808
- (60). 10.3390/cancers3033029
- (61). 10.1016/j.ejphar.2017.12.027
- (62). 10.1016/j.dnarep.2018.04.002
- (63). 10.1038/nrc2441
- (64). 10.2174/1570180813666160712224752
- (65). 10.1021/jf000892m
- (66). 10.1186/s12885-016-2121-8
- (67). 10.1016/j.canlet.2018.07.018
- (68). 10.1016/j.brainresbull.2015.09.002
- (69). 10.3390/nu8090552
- (70). 10.1016/j.cbpa.2004.04.011
- (71). 10.15430/JCP.2017.22.1.1
- (72). 10.1016/j.biopha.2016.10.030
- (73). 10.1016/j.neuropharm.2014.07.012
- (74). 10.1016/j.ijpharm.2012.07.015
- (75). 10.1002/ijc.26308
- (76). 10.1080/14786419.2015.1046381
- (77). 10.1016/S1535-6108(02)00241-6
- (78). 10.1016/j.cyto.2018.03.042
- (79). 10.3322/caac.21319
- (80). 10.1016/j.lfs.2012.05.003
- (81). 10.1016/j.cbi.2006.08.018
- (82). 10.1248/bpb.b14-00780
- (83). 10.32607/20758251-2015-7-3-133-139
- (84). 10.1038/nrc2590
- (85). 10.1055/s-0028-1088314
- (86). 10.1016/j.ijpharm.2013.01.050
- (87). 10.1016/j.tiv.2011.11.011
- (88). 10.1021/jf9031684
- (89). 10.1207/s15327914nc5301_3
- (90). 10.1365/s10337-004-0302-0
- (91). 10.1038/nrc3792
- (92). 10.1159/000438535
- (93). 10.1038/nrc1189
- (94). 10.3390/molecules191220839
- (95). 10.1155/2018/4637861
- (96). 10.1016/j.foodchem.2013.04.077
- (97). 10.1097/CEJ.0000000000000128
- (98). 10.1089/ars.2012.4573
- (99). 10.1016/j.tibs.2011.08.009
- (100). 10.1186/1478-811X-9-10
- (101). 10.1038/onc.2011.497
- (102). 10.7314/APJCP.2012.13.4.1431
- (103). 10.1016/j.jff.2017.02.018
- (104). 10.1016/S0098-2997(03)00030-X
- (105). 10.1158/1078-0432.CCR-03-0527
- (106). 10.1016/j.cbi.2014.02.002
- (107). 10.1016/j.bcp.2018.06.003
- (108). 10.1038/srep07758
- (109). 10.1016/j.canlet.2009.02.051
- (110). 10.1016/j.dnarep.2014.07.001
- (111). 10.1074/jbc.M708426200
- (112). 10.1016/j.yexcr.2018.05.024
- (113). 10.1093/jnci/91.6.547
- (114). 10.1016/j.gene.2017.10.046
More Article by Dr. Salman Ahmed
The seeds of cleome viscosa are used in traditional systems of medicine for the treatment of many diseases in asia. this study evaluated fixed oil from the seeds of cleome viscosa...
Plants have been used as medicine for the treatment of diseases for thousands of years. these herbal remedies, although natural, can cause some serious damaging effects on the vita...
The current study was conducted to explore the antiemetic activity of ten aromatic medicinal plants viz., carissa carandus l. (fruits), chichorium intybus l (flowers), cinnamum tam...
Crude methanol extracts of the leaves of adenanthera pavonina l., peltoforum roxburghii l, prosopis cineraria l., and prosopis juliflora dc., were evaluated for anti-emetic activit...