Dr. Salman Ahmed

Antiurolithiatic effects of pentacyclic triterpenes: the distance traveled from therapeutic aspects

• Authors Details :  
• Devina Lobine,  
• Salman Ahmed,  
• Michael Aschner,  
• Haroon Khan,  
• Hamed Mirzaei ,  
• Mohamad F. Mahomoodally

Journal title : Drug Development Research

Publisher : Wiley

Online ISSN : 1098-2299

Page Number : 671-684

Journal volume : 81

Journal issue : 6

316 Views Reviews Article

Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds with immense potential as treatments for kidney stones. This review aims to provide an integrative description of how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various antioxidant, anti-inflammatory, diuretic, and angiotensin-converting enzyme inhibition mechanisms. Some pentacylic triterpenes showing promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives on developing pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.

Article DOI & Crossmark Data

DOI : https://doi.org/10.1002/ddr.21670

Article Subject Details

• Health Science
• Medicine
• Nephrology
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• Antiurolithiatic
• Medicinal plants
• Medicinal uses
• Pharmacology
• Phytochemistry
• Triterpenes

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