Dr. Salman Ahmed

Antitussive effect of aerial parts of caesalpinia pulcherrima by sulphur dioxide induced cough in rats

• Authors Details :  
• Syed Muhammad Umer Gilani,  
• Rifat Roshan,  
• Salman Ahmed ,  
• Muhammad Mohtasheemul Hasan

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Natural products have played an essential role in treating human diseases for thousands of years. According to WHO, 80% of the world’s population relies on traditional medicines to cure and prevent ailments. Numerous plants have been reported to have antitussive activity. Our present study aimed to evaluate the antitussive effect of aerial parts of ethanolic extract of Caesalpinia pulcherrima (Caesalpiniaceae) at 200 and 400 mg/kg doses in healthy albino rats. Caesalpinia pulcherrima is an ornamental plant, usually 3.7-4.3 m in height, known as Peacock flower and is used traditionally to treat cough, bronchitis and asthma. Cough significantly affects human health and is the most common reason to visit physicians. Cough may be produced due to disease, allergens, pollutants and respiratory infections. Any mechanical or inflammatory change provokes the afferent or sensory nerves in the larynx and tracheobronchial, resulting in a cough. In this study, cough was induced by using the sulphur dioxide induction method. Animals were divided into four groups of 7 animals each, and all the drugs were administered orally. Group I was a control group, while group II was a standard taking Prospane. The extract showed highly significant results at 200 and 400 mg/kg doses compared to the control. So, it proves and supports the traditional use of Caesalpinia pulcherrima to relieve cough.

Article Subject Details

• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• Antitussive
• Medicinal plants
• Pharmacognosy
• Pharmacology
• Pharmacy
• Sulphur dioxide induced cough

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