Dr. Salman Ahmed

Analgesic and anti-inflammatory potential of four varieties of bell pepper (capsicum annum l.) in rodents

• Authors Details :  
• Nimra Mazhar,  
• Sadia Ghousia Baig ,  
• Salman Ahmed,  
• Muhammad Mohtasheemul Hasan,  
• Amber Palla,  
• Ghazala Ishrat

Journal title : pakistan journal of pharmaceutical sciences

Publisher : Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi

Print ISSN : 1011-601X

Journal volume : 34

Journal issue : 4

304 Views Original Article

The aim of the study was to evaluate the analgesic and anti-inflammatory activity of four different colored (green, yellow, orange, and red) sweet bell peppers (Capsicum annuum L.) are available at the local market in Karachi, Pakistan. Their 95% ethanol extracts at 200 and 400 mg/kg were prepared and compared with commonly used analgesics (aspirin) and anti-inflammatory agents supporting its traditional use. The analgesic effects of 95% ethanol extracts of Capsicum annum L. were investigated by acetic acid-induced writhing, tail immersion and hot plate test. The anti-inflammatory activities were observed using carrageenan-induced edema of the hind paw in rats. Animals were divided into ten groups (n=7): (1) Control (2) CAG 200 (3) CAG 400 (4) CAR 200 (5) CAR 400 (6) CAO 200 (7) CAO 400 (8) CAY 200 (9) CAY 400 and (10) Standard. All the extracts were given orally. Acute toxicity was also determined by increasing the dose to 3000 mg/kg, which showed no evidence of mortality. All extracts of Capsicum significantly increased the hot plate pain threshold and remarkably reduced the carrageenan-induced rat paw oedema. Results obtained were compared with the corresponding control group, revealing that the fresh fruit extract of all four kinds of bell pepper (200 mg/kg and 400mg/kg) possess anti-inflammatory and pain-suppressing activities possibly mediated via PG synthesis inhibition

Article DOI & Crossmark Data

DOI : https://doi.org/10.36721/PJPS.2021.34.4.REG.1369-1376.1

Article Subject Details

• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• anti-nociceptive
• Capsaicin
• di-hydrocapsaicin
• Phenolic compounds
• Capsicum annum

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