Dr. Salman Ahmed

Analgesic and anti-inflammatory activities of fixed oil of macrotyloma uniflorum (lam.) verdc. in mice and rats

• Authors Details :  
• Syeda Anum Fatima,  
• Sadia Ghousia Baig,  
• Muhammad Mohtasheem Ul Hasan,  
• Salman Ahmed ,  
• Salma

305 Views Original Article

Macrotyloma uniflorum, commonly known as horse gram or kulthi bean, is grown as a pulse for livestock and human consumption. The beans contain about 1.3% fat, 18% protein, 15% carbohydrate, and vitamins and minerals. Traditional medicine uses it as an antihyperglycemic, antioxidant, antihypertensive and diuretic. Other important medicinal uses include the treatment of renal stones, obesity, piles, oedema and fever. The present study evaluated analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and anti-inflammatory (carrageenan-induced paw oedema in rats) activities of Macrotyloma uniflorum fixed oil (MUFO). Four groups were included in the study: Group I: Normal Saline Control (2ml/kg), Group II: MUFO (2ml/kg), Group III: MUFO (4ml/kg), and Group IV: Standard Acetyl salicylic acid (ASA 300mg/kg). All results were significant; however, the tail flick and paw oedema tests observed a delayed onset of action. The oil's acute oral toxicity was also checked in mice and was found safe up to a 4ml/kg dose, as no signs of toxicity and mortality were observed. It is concluded that Macrotyloma uniflorum fixed oil may possess analgesic and anti-inflammatory activity, which can be related to a peripheral mechanism of action.

Article Subject Details

• Health Science
• Medicine
• Pain
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• Analgesic
• Anti-inflammatory
• Fixed oil
• Macrotyloma uniflorum
• Pharmacognosy
• Pharmacology
• Pharmacy

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