Dr. Salman Ahmed
Acute systemic toxicity of four mimosaceous plants leaves in mice
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Nature provides drugs in the form of medicinal plants to cure all ailments of mankind with fewer side effects. These medicinal plants can cause some serious damaging effects on the vital organs of the body too; there is a need of toxicity studies to provide their safe use both in human and animals. The present study reports the acute systemic toxicity of methanolic extracts of leaves of Adenanthera pavonina L., Peltophorum roxburghii Deneger., Prosopis cineraria Druce and Prosopis juliflora DC., (Mimosaceae) in swiss albino mice to explore their suitable doses for pharmacological screening. Observations were made immediately and after 1/2, 1, 4, 24 and 48hours of intraperitoneal drug administration. Adenanthera pavonina extract at the dose of 150 mg/kg body weight is considered to be safe. Whereas remaining extracts of investigated plants are relatively safe at the dose of 100 mg/kg body weight.
Article Subject Details
Article Keywords Details
- Acute systematic toxicity
- Adenanthera pavonina
- Methanol extract
- Mimosaceae
- Peltophorum roxburghii
- Prosopis cineraria
- Prosopis juliflora
- Swiss albino mice
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